taylor-mighell.bsky.social
Taylor Mighell
@taylor-mighell.bsky.social
82 followers 100 following 2 posts
Postdoc @crg.eu Barcelona GPCRs | synthetic biology | genomics
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Reposted by Taylor Mighell
natsmb.nature.com
Nature Structural & Molecular Biology @natsmb.nature.com · 17d
New online: A small molecule stabilizer rescues the surface expression of nearly all missense variants in a GPCR
A small molecule stabilizer rescues the surface expression of nearly all missense variants in a GPCR
Nature Structural & Molecular Biology, Published online: 22 September 2025; doi:10.1038/s41594-025-01659-6Many mutations cause disease because they destabilize proteins. Here, Mighell and Lehner show that a single small molecule can correct the destabilization caused by nearly all pathogenic mutations in a human GPCR.
go.nature.com
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taylor-mighell.bsky.social
Taylor Mighell @taylor-mighell.bsky.social · Jun 1
Shoutout to the Maxi @maxstammnitz.bsky.social for pioneering dose-response methods and check out his pre-print too: www.biorxiv.org/content/10.1...
The genetic architecture of an allosteric hormone receptor
Many proteins function as switches, detecting chemicals and transducing their concentrations into cellular responses. Receptor switches are key to the integration of environmental signals, yet it is n...
www.biorxiv.org
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taylor-mighell.bsky.social
Taylor Mighell @taylor-mighell.bsky.social · Jun 1
GPCR-MAPS is now live! www.biorxiv.org/content/10.1...
A new platform for high resolution functional mapping of GPCRs with massive mutagenesis. We identify the core activation network, residues involved in biased signaling, and generate >7,000 full dose response curves. With @benlehner.bsky.social
The genetic architecture of G-protein coupled receptor signaling
G-protein coupled receptors (GPCRs) are the most abundant class of human receptors and drug targets. The vast majority of GPCR drugs bind the conserved orthosteric pocket, which can lead to non-specif...
www.biorxiv.org
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Reposted by Taylor Mighell
biorxiv-sysbio.bsky.social
bioRxiv SysBio @biorxiv-sysbio.bsky.social · May 31
The genetic architecture of G-protein coupled receptor signaling https://www.biorxiv.org/content/10.1101/2025.05.30.656974v1
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Reposted by Taylor Mighell
jonnyfrazer.bsky.social
Jonathan Frazer @jonnyfrazer.bsky.social · May 23
Another local hero! Up next at #VariantEffect25:
@taylor-mighell.bsky.social from @benlehner.bsky.social lab presents: Two wrongs make a right: can GPCR antagonists rescue mutant receptors? 🧬🧪🔁
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Reposted by Taylor Mighell
isabellease.bsky.social
Isabelle Zane @isabellease.bsky.social · May 23
@taylor-mighell.bsky.social at #VariantEffect25
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Reposted by Taylor Mighell
crg.eu
Centre de Regulació Genòmica (CRG) @crg.eu · Jan 8
Introducing Human Domainome v1, the largest and most comprehensive library of human protein variants to date, which maps the effects of +500K mutations across 522 domains. The study by @benlehner.bsky.social and Toni Beltran is out now in @nature.com. Illustration by @queralttolosa.bsky.social.
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Reposted by Taylor Mighell
benlehner.bsky.social
Ben Lehner @benlehner.bsky.social · Jan 19
Nice highlighting of @taylor-mighell.bsky.social's GPCR pharmacochaperone preprint by @dereklowe.bsky.social @science.org www.biorxiv.org/content/10.1...
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Reposted by Taylor Mighell
crg.eu
Centre de Regulació Genòmica (CRG) @crg.eu · Jan 9
Missense mutations are responsible for many heritable genetic disorders. Researchers led by @benlehner.bsky.social are carrying out large-scale experiments to understand why. Unstable proteins are emerging as a clear mechanism of action. Today in @elpais.com by @manuelansede.bsky.social.
The first ‘human domainome’ reveals the cause of a multitude of diseases
An ingenious large-scale experiment in Barcelona has led to the creation of a catalog detailing the effects of half a million DNA mutations
english.elpais.com
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