Ted Satterthwaite
@ted-satterthwaite.bsky.social
1K followers 410 following 76 posts
McLure II Professor PennLINC | University of Pennsylvania www.pennlinc.io neurodevelopment, neuroimaging, neuroinformatics, & mental health
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ted-satterthwaite.bsky.social
#OHBM2025 is here and the champs from @pennlinc.bsky.social have brought their freshest work express from Philly to Brisbane. Thread below . . .please reach out + come say hi -- always looking to talk science + make new friends!!!
a cartoon of snoopy dancing with the words oh yeah written above him
ALT: a cartoon of snoopy dancing with the words oh yeah written above him
media.tenor.com
ted-satterthwaite.bsky.social
Wooohooooo!!! CONGRATS ARMIN!!!!
Reposted by Ted Satterthwaite
abcd-repronim.bsky.social
Want to learn more about the Adolescent Brain Cognitive Development study?👀 Check out the ABCD-ReproNim course! The Fall 2025 course is going on NOW✨ Students may have the opportunity to participate in the 2026 hackathon in Miami🏝️ For more info: abcd-repronim.org 🎉
Reposted by Ted Satterthwaite
emilyjacobs.bsky.social
When @laurapritschet.bsky.social & Pavel Shapturenka set out to build the 28&Me + 28&He datasets, I don't think any of us could've predicted the spectacularly creative ways the datasets would be used years later. That's the power of open science. 👇🏼
Reposted by Ted Satterthwaite
mallarchak.bsky.social
Check out this great summary of our recent paper on the impact of exposure to #THC during gestation.

Thanks @douglasresearch.bsky.social !!

Orig paper here:

www.nature.com/articles/s41...
Reposted by Ted Satterthwaite
borismontreal.bsky.social
🚨 New paper in Nature Methods:
HippoMaps: multiscale cartography of the human hippocampus

Open-source tools & data to explore structure and function of the 🍤🧠 (histology, in/ex vivo MRI, iEEG)

Led by @jordandekraker.bsky.social

docs: hippomaps.readthedocs.io
paper: doi.org/10.1038/s415...
ted-satterthwaite.bsky.social
Delighted to see the paper describing the Reproducible Brain Charts open data resource now out in @cp-neuron.bsky.social. Paper + link to data below; huge congrats to @goliashf.bsky.social @milhammichael.bsky.social and the whole RBC team. Lots of people (>2,500 downloads) are already using RBC!
Cumulative RBC downloads over time.  Lots of people are using RBC, with >2,500 downloads by time of RBC paper publication.  Woo!!
Reposted by Ted Satterthwaite
misicbata.bsky.social
Network spreading and local biological vulnerability in amyotrophic lateral sclerosis |
doi.org/10.1038/s420...

How do brain network structure and local biological features shape the spatial patterning of atrophy in ALS? @asafarahani.bsky.social investigates ⤵️
ted-satterthwaite.bsky.social
Just remarkable work— bravo!!!
gozziale.bsky.social
🚨 Excited to share the latest preprint form the lab ➡️https://tinyurl.com/32d3be9f

Here we tackle a long-standing chicken-or-egg 🐣🥚question in #autism and developmental neuroscience

➡️ Is excitation–inhibition (E:I) imbalance a "cause" or a "consequence" of #autism?

Check out what we found!
🧵1/n
Reposted by Ted Satterthwaite
vincebaz.bsky.social
Our recent work on spin tests is now published in Imaging Neuroscience🎉

As always, the code to reproduce our results and figures is available on github: github.com/netneurolab/...
misicbata.bsky.social
The effect of spherical projections on spin tests for brain maps | doi.org/10.1162/IMAG...

Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️
ted-satterthwaite.bsky.social
Wooohoo!!! CONGRATS!!!
cmakowski.bsky.social
The BRIDGE Lab has officially been launched! 🔗 bridgelab.ucsd.edu 👉 we Bridge Research in Imaging, Development, Genetics and Emerging mental health 🧠 🧬 🚸 🌉 please don't be shy to reach out if you are interested in learning more about our lab's research!
BRIDGE Lab
Welcome to the BRIDGE Lab (Bridging Research across Imaging, Development, Genetics, and Emerging Mental Health) within the Department of Psychiatry at the University of California San Diego! Our resea...
bridgelab.ucsd.edu
Reposted by Ted Satterthwaite
lune-bellec.bsky.social
Many brain imaging “biomarkers” for autism have been proposed. Most aim for balanced accuracy (matching sensivity/specificity) on datasets where cases and controls are split 50/50. 1/🧵
Reposted by Ted Satterthwaite
imagingneurosci.bsky.social
Launched in 2023, Imaging Neuroscience is now firmly established, with full indexing (PubMed, etc.) and 700 papers to date.

We're very happy to announce that we are able to reduce the APC to $1400.

Huge thanks to all authors, reviewers, editorial team+board, and MIT Press.
ted-satterthwaite.bsky.social
Just massive congrats to Amelie Rauland (not on bluesky), who did a truly superb job with this project. Super fun as always work with stellar co-mentors @sbe.bsky.social and @cieslakmatt.bsky.social, as well as an amazing team -- @stevenmeisler.com @aarona-b.bsky.social @joelleba.bsky.social
ted-satterthwaite.bsky.social
These results emphasize that many legacy and clinical dMRI datasets are a promising, untapped resource. Leveraging these data could enable large-scale studies, advance brain mapping and rare disease research, and fuel AI methods that thrive on massive datasets 🚀
ted-satterthwaite.bsky.social
Bottom line? Single-shell dMRI data with limited angular resolution can reliably reconstruct WM tracts! Features from these reconstructions are robust enough to support brain-behavior analyses. SS3T offered the best balance of reliability, completeness, & prediction accuracy 9/n
ted-satterthwaite.bsky.social
Finally, when predicting cognitive performance from different sets of bundle features, GQI and SS3T outperformed CSD. Overall, we observed prediction accuracies comparable to those predicting cognition from WM features extracted from more advanced scans. 8/n
ted-satterthwaite.bsky.social
We also found that SS3T had the highest ICC for both volumetric and microstructure (FA, MD) features 7/n
ted-satterthwaite.bsky.social
But are reconstructions also biologically plausible? Amelie found that GQI had the highest specificity -- but often yielded incomplete bundles. CSD showed the opposite-- over inclusive bundles with lower specificity. SS3T showed the best balance between sensitivity and specificity. 6/n
ted-satterthwaite.bsky.social
But are reconstructions also biologically plausible? Amelie found that GQI had the highest specificity -- but often yielded incomplete bundles. CSD showed the opposite-- over inclusive bundles with lower specificity. SS3T showed the best balance between sensitivity and specificity. 6/n
ted-satterthwaite.bsky.social
Amelie found that all major WM bundles can be reliably reconstructed for all three reconstruction methods. Furthermore, methods showed high discriminability (>0.94), but SS3T yielded the highest. 5/n
ted-satterthwaite.bsky.social
In our study, Amelie reconstructed 60 WM tracts in test-retest data from 1221 subjects of the PNC dataset with single-shell, 32-direction dMRI acquisitions. Three methods for ODF reconstruction applicable to this type of data were compared: GQI, CSD, and SS3T. 4/n