Ankith Sharma
@thebioguy.bsky.social
A professional photographer of the microscopic world. Postdoc in Ting Wu lab @Harvard. PhD from Musser Lab @TAMU.
Reposted by Ankith Sharma
Exciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Interphase chromosome conformation is specified by distinct folding programmes inherited through mitotic chromosomes or the cytoplasm - Nature Cell Biology
Schooley et al. find that mitotically bookmarked loci drive a transient chromosome folding state during G1 entry that is subsequently modulated by factors inherited through the cytoplasm.
www.nature.com
December 22, 2025 at 11:45 AM
Exciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ankith Sharma
#ICYMI We have appointed three new Associate Faculty members: Ahmad Khalil, Jarad Mason, and Ting Wu. Their diverse expertise in synthetic biology, materials science, and genome research will contribute to the Institute's mission of improving the health of people and the planet.
Wyss Institute appoints three new Associate Faculty members: Ahmad Khalil, Jarad Mason, and Ting Wu
By Jessica Leff The Wyss Institute is proud to welcome three new Associate Faculty members: Ahmad (Mo) Khalil, Ph.D., Jarad Mason, Ph.D., and Chao-ting (Ting) Wu, Ph.D. Each has a history of collabora...
wyss.harvard.edu
December 18, 2025 at 4:31 PM
#ICYMI We have appointed three new Associate Faculty members: Ahmad Khalil, Jarad Mason, and Ting Wu. Their diverse expertise in synthetic biology, materials science, and genome research will contribute to the Institute's mission of improving the health of people and the planet.
Reposted by Ankith Sharma
🚨🚨New paper out in @natcomms.nature.com!!
Come for the first large-scale analysis of plasmid copy number across species,
stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬
👉 www.nature.com/articles/s41...
Come for the first large-scale analysis of plasmid copy number across species,
stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬
👉 www.nature.com/articles/s41...
Universal rules govern plasmid copy number - Nature Communications
Plasmids exhibit a broad range of sizes and copies per cell, and these two parameters appear to be negatively correlated. Here, Ramiro-Martínez et al. analyse the copy number of thousands of diverse b...
www.nature.com
July 2, 2025 at 11:08 AM
🚨🚨New paper out in @natcomms.nature.com!!
Come for the first large-scale analysis of plasmid copy number across species,
stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬
👉 www.nature.com/articles/s41...
Come for the first large-scale analysis of plasmid copy number across species,
stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬
👉 www.nature.com/articles/s41...
Reposted by Ankith Sharma
Johannes Stein @jmstein.bsky.social from Harvard/Wyss reports impressive work on imaging the nuclear ultrastructure of cells using cryosections and DNA-PAINT #SMLMS2025
August 28, 2025 at 8:53 AM
Johannes Stein @jmstein.bsky.social from Harvard/Wyss reports impressive work on imaging the nuclear ultrastructure of cells using cryosections and DNA-PAINT #SMLMS2025
Reposted by Ankith Sharma
Ever wondered where cargo travels through the central channel of the NPC? Siegfried Musser lab @musser-lab.bsky.social measured that in living cells using MINFLUX. Fascinating data! #SMLMS2025
August 28, 2025 at 2:26 PM
Ever wondered where cargo travels through the central channel of the NPC? Siegfried Musser lab @musser-lab.bsky.social measured that in living cells using MINFLUX. Fascinating data! #SMLMS2025
I'm excited to share the preprint of my PhD work from
@musser-lab.bsky.social on understanding the structure and dynamics of FUS condensates at the nanoscale. We’ve used different single-molecule microscopy techniques, including MINFLUX, to understand FUS condensate behavior.
@musser-lab.bsky.social on understanding the structure and dynamics of FUS condensates at the nanoscale. We’ve used different single-molecule microscopy techniques, including MINFLUX, to understand FUS condensate behavior.
Clustering within a single-component biomolecular condensate https://www.biorxiv.org/content/10.1101/2025.08.18.670948v1
August 25, 2025 at 1:38 AM
I'm excited to share the preprint of my PhD work from
@musser-lab.bsky.social on understanding the structure and dynamics of FUS condensates at the nanoscale. We’ve used different single-molecule microscopy techniques, including MINFLUX, to understand FUS condensate behavior.
@musser-lab.bsky.social on understanding the structure and dynamics of FUS condensates at the nanoscale. We’ve used different single-molecule microscopy techniques, including MINFLUX, to understand FUS condensate behavior.
Reposted by Ankith Sharma
There is still time to apply to become part of our team at Nature Biomedical Engineering! Please share! springernature.wd3.myworkdayjobs.com/SpringerNatu...
a blue sign that says we are hiring
ALT: a blue sign that says we are hiring
media.tenor.com
August 14, 2025 at 8:44 PM
There is still time to apply to become part of our team at Nature Biomedical Engineering! Please share! springernature.wd3.myworkdayjobs.com/SpringerNatu...
Reposted by Ankith Sharma
🚨New preprint from the lab🚨
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...
Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen
The nuclear periphery is a key site for heterochromatin organization in eukaryotic cells, where lamina-associated domains (LADs) promote transcriptional repression and genome stability. Despite their ...
www.biorxiv.org
August 14, 2025 at 7:01 PM
🚨New preprint from the lab🚨
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...
Cool new technique from @jmstein.bsky.social ! Great way to get the precision of DNA-PAINT away from the coverslip!!
(1/n) DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin sectioning makes it happen!
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
August 14, 2025 at 1:21 AM
Cool new technique from @jmstein.bsky.social ! Great way to get the precision of DNA-PAINT away from the coverslip!!
Reposted by Ankith Sharma
(1/n) DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin sectioning makes it happen!
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
August 13, 2025 at 2:19 PM
(1/n) DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin sectioning makes it happen!
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
Looking forward to sharing our research with the IDP community tomorrow!
Announcing the joint IDPSeminars / BPS IDP Subgroup Trainee Symposium Speakers!
Join us on Mar 27, 12–2pm CST for 6 exciting talks focused on Intrinsically Disordered Proteins as part of #BophysicsWeek2025 with the @biophysicalsoc.bsky.social
Sign up now at docs.google.com/forms/d/1L_K...
Join us on Mar 27, 12–2pm CST for 6 exciting talks focused on Intrinsically Disordered Proteins as part of #BophysicsWeek2025 with the @biophysicalsoc.bsky.social
Sign up now at docs.google.com/forms/d/1L_K...
March 27, 2025 at 1:59 AM
Looking forward to sharing our research with the IDP community tomorrow!
Reposted by Ankith Sharma
Paper visualizing traffic through nuclear pores unlocks the full potential of #MINFLUX:
2-color 3D tracking with sub-ms time resolution and single-digit nm localization precision 💪
Congrats @abhishek-sau.bsky.social, @musser-lab.bsky.social, @thebioguy.bsky.social, @EMBL, et al!
#SMLM #nuclearpore
2-color 3D tracking with sub-ms time resolution and single-digit nm localization precision 💪
Congrats @abhishek-sau.bsky.social, @musser-lab.bsky.social, @thebioguy.bsky.social, @EMBL, et al!
#SMLM #nuclearpore
I’m excited to share our latest research from the Musser Lab, published today in Nature. Using two-color 3D MINFLUX, we directly visualized nuclear import and export events through transport-active nuclear pores. (1/5)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Overlapping nuclear import and export paths unveiled by two-colour MINFLUX - Nature
High spatiotemporal precision tracking using 3D MINFLUX shows that nuclear import and export occur in overlapping regions of the central pore, providing insight into transport across the nuclear pore ...
www.nature.com
March 21, 2025 at 10:12 AM
Paper visualizing traffic through nuclear pores unlocks the full potential of #MINFLUX:
2-color 3D tracking with sub-ms time resolution and single-digit nm localization precision 💪
Congrats @abhishek-sau.bsky.social, @musser-lab.bsky.social, @thebioguy.bsky.social, @EMBL, et al!
#SMLM #nuclearpore
2-color 3D tracking with sub-ms time resolution and single-digit nm localization precision 💪
Congrats @abhishek-sau.bsky.social, @musser-lab.bsky.social, @thebioguy.bsky.social, @EMBL, et al!
#SMLM #nuclearpore
Our work on resolving nuclear transport using MINFLUX is finally out! Great work from Sig, Abhishek and all the coauthors. Thrilled to have had the opportunity to be a part of it!
I’m excited to share our latest research from the Musser Lab, published today in Nature. Using two-color 3D MINFLUX, we directly visualized nuclear import and export events through transport-active nuclear pores. (1/5)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Overlapping nuclear import and export paths unveiled by two-colour MINFLUX - Nature
High spatiotemporal precision tracking using 3D MINFLUX shows that nuclear import and export occur in overlapping regions of the central pore, providing insight into transport across the nuclear pore ...
www.nature.com
March 21, 2025 at 3:48 AM
Our work on resolving nuclear transport using MINFLUX is finally out! Great work from Sig, Abhishek and all the coauthors. Thrilled to have had the opportunity to be a part of it!