theghoshlab.bsky.social
@theghoshlab.bsky.social
Reposted
(please share) Immediate #postdoc job opening in the Millman lab at WashU Med (St. Louis, MO).

Want to develop next-generation pancreatic islets for the study and treatment of diabetes? Email your CV to apply

sites.wustl.edu/millmanlab/
December 19, 2025 at 8:25 PM
New preprint from our lab! We investigated how MSCs lose potency during serial passaging - a critical bottleneck in MSC manufacturing, and how epigenetic interventions can help preserve their quality at the therapeutic endpoint. www.biorxiv.org/content/10.6...
Mechanoepigenetic Targeting of Histone Methyltransferase EZH2 Increases Potential of Scalable Manufacturing in Human Derived Primary Mesenchymal Stromal Cells
Manufacturing clinical grade mesenchymal stromal cells (MSCs) remains a major bottleneck for cell-based therapies, as extensive in-vitro expansion on standard tissue-culture plastic (TCP) drives loss ...
www.biorxiv.org
December 17, 2025 at 4:23 PM
This is my first Bluesky post to a very limited connection. New paper published from our lab and it is open access! What happens to the chromatin structure of mesenchymal stem/stromal cells when they’re exposed to high levels of reactive oxygen species (ROS)?
doi.org/10.1002/adbi...
Hyperoxia Induced Alteration of Chromatin Structure in Human Bone Marrow Derived Primary Mesenchymal Stromal Cells
Chromatin, which organizes DNA, changes its structure to adapt to stress like high oxygen levels (hyperoxia), which can damage cells. Researchers developed a technique to observe these changes and fo....
doi.org
June 10, 2025 at 4:09 PM