Using advanced microscopy and multi-omics approaches, we identify histone methyltransferase EZH2, along with key chromatin remodelers, as central regulators of MSC phenotypic drift during expansion.

Turns out, epigenetic regulation plays a central role in how cells respond to oxidative stress having implications for regenerative medicine and aging research.
Have a look! Executed by a team of PhD, MS and undergraduate students in our lab.#stemcells #epigenetics #chromatin #regenerativemedicine

What we found: ROS triggers striking chromatin compaction and remodeling — but pretreatment with a selective EZH2 inhibitor (GSK126) alters this response, preserving chromatin accessibility and reducing DNA damage.

This can occur at critical moments — like after therapeutic expansion and delivery to injury sites, or during inflammation in native tissues. To explore this, we combined high-resolution live-cell imaging with ATAC-seq to track real-time changes in chromatin architecture.