The Lancet Diabetes & Endocrinology
@thelancetendo.bsky.social
Your leading source of international, cutting-edge research, review, and opinion in clinical #diabetes and #endocrinology. IF=41·8.
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In 2024, one in nine adults worldwide was living with diabetes. The number of adults with #diabetes in 2024 exceeded 500 million and is projected to rise to close to 900 million by 2050 www.thelancet.com/journals/lan...
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December 19, 2025 at 9:31 AM
In 2024, one in nine adults worldwide was living with diabetes. The number of adults with #diabetes in 2024 exceeded 500 million and is projected to rise to close to 900 million by 2050 www.thelancet.com/journals/lan...
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#MedSky #EndoSky
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The recommendations in this Consensus Statement emphasise the value of #CGM during #preconception and #pregnancy for women with pregestational type 1 #diabetes in reducing pregnancy complications www.thelancet.com/journals/lan...
#T1D #T2D #GDM
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#T1D #T2D #GDM
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December 19, 2025 at 9:23 AM
The recommendations in this Consensus Statement emphasise the value of #CGM during #preconception and #pregnancy for women with pregestational type 1 #diabetes in reducing pregnancy complications www.thelancet.com/journals/lan...
#T1D #T2D #GDM
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#T1D #T2D #GDM
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New—Zodasiran, an RNAi therapeutic targeting ANGPTL3, for treating patients with #homozygous #familial #hypercholesterolaemia (GATEWAY): an open-label, randomised, phase 2 trial thelancet.com/journals/lan...
#HoFH
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#HoFH
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December 18, 2025 at 11:41 PM
New—Zodasiran, an RNAi therapeutic targeting ANGPTL3, for treating patients with #homozygous #familial #hypercholesterolaemia (GATEWAY): an open-label, randomised, phase 2 trial thelancet.com/journals/lan...
#HoFH
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#HoFH
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Targeting individuals at high genetic risk of type 1 #diabetes could facilitate efficient screening and identification of presymptomatic type 1 diabetes, helping better inform the natural history of the disease in adults www.thelancet.com/journals/lan... #T1D
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December 18, 2025 at 9:22 AM
New—Application of continuous glucose monitoring & automated insulin delivery technologies for pregnant women with type 1, type 2, or #gestational #diabetes: an international consensus statement thelancet.com/journals/lan...
#T1D #T2D #GDM #CGM #AID
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#T1D #T2D #GDM #CGM #AID
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December 18, 2025 at 6:57 AM
According to the 11th edition IDF Diabetes Atlas, an estimated 11·11% of adults worldwide were living with diabetes in 2024, and the prevalence is expected to reach 12·96% by 2050 thelancet.com/journals/lan... #diabetes
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December 17, 2025 at 8:46 AM
According to the 11th edition IDF Diabetes Atlas, an estimated 11·11% of adults worldwide were living with diabetes in 2024, and the prevalence is expected to reach 12·96% by 2050 thelancet.com/journals/lan... #diabetes
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New—11th edition of the IDF Diabetes Atlas: global, regional, and national diabetes prevalence estimates for 2024 and projections for 2050 thelancet.com/journals/lan... #diabetes
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December 16, 2025 at 8:49 AM
New—11th edition of the IDF Diabetes Atlas: global, regional, and national diabetes prevalence estimates for 2024 and projections for 2050 thelancet.com/journals/lan... #diabetes
#FREE to read with registration (also FREE)
#MedSky #EndoSky
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Metabolic dysfunction-associated steatotic liver disease: heterogeneous pathomechanisms and effectiveness of metabolism-based treatment
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#MASLD #obesity #lipodystrophy
#OpenAccess
#MedSky #EndoSky #LiverSky
www.thelancet.com/journals/lan...
#MASLD #obesity #lipodystrophy
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December 14, 2025 at 12:33 PM
Metabolic dysfunction-associated steatotic liver disease: heterogeneous pathomechanisms and effectiveness of metabolism-based treatment
www.thelancet.com/journals/lan...
#MASLD #obesity #lipodystrophy
#OpenAccess
#MedSky #EndoSky #LiverSky
www.thelancet.com/journals/lan...
#MASLD #obesity #lipodystrophy
#OpenAccess
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Incretin hormones—glucagon-like peptide-1 (GLP-1) & glucose-dependent insulinotropic peptide (GIP)—act as a critical link connecting #digestion, #metabolism, & #cardiovascular function, supporting physiological adaptations to nutrient intake thelancet.com/journals/lan...
#incretins
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#incretins
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December 13, 2025 at 2:09 PM
Incretin hormones—glucagon-like peptide-1 (GLP-1) & glucose-dependent insulinotropic peptide (GIP)—act as a critical link connecting #digestion, #metabolism, & #cardiovascular function, supporting physiological adaptations to nutrient intake thelancet.com/journals/lan...
#incretins
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#incretins
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The prevalence of overweight and obesity in China has continued to increase over the last decade, with mounting health and economic consequences www.thelancet.com/journals/lan...
#obesity #China
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#obesity #China
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December 11, 2025 at 7:19 AM
The prevalence of overweight and obesity in China has continued to increase over the last decade, with mounting health and economic consequences www.thelancet.com/journals/lan...
#obesity #China
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#obesity #China
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Read our January 2026 Issue, featuring adrenal tumour imaging, type 2 diabetes, heart failure, atherosclerotic cardiovascular disease, cancer, gestational diabetes, CGM, type 1 diabetes, obesity, ultra-processed foods & much more tinyurl.com/mwfu4c6m
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December 9, 2025 at 11:35 PM
Read our January 2026 Issue, featuring adrenal tumour imaging, type 2 diabetes, heart failure, atherosclerotic cardiovascular disease, cancer, gestational diabetes, CGM, type 1 diabetes, obesity, ultra-processed foods & much more tinyurl.com/mwfu4c6m
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Futility of plasmapheresis, insulin in normoglycaemic individuals, or heparin in the treatment of #hypertriglyceridaemia-induced acute #pancreatitis www.thelancet.com/journals/lan...
#triglycerides
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#triglycerides
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December 9, 2025 at 9:28 AM
Futility of plasmapheresis, insulin in normoglycaemic individuals, or heparin in the treatment of #hypertriglyceridaemia-induced acute #pancreatitis www.thelancet.com/journals/lan...
#triglycerides
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#triglycerides
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The incidence & prevalence of #thyroid #eye disease (TED) have presumably declined in the last decades, possibly related to more attention given to risk factors (eg, smoking) & faster diagnosis & earlier treatment of #Graves’ #hyperthyroidism www.thelancet.com/journals/lan...
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December 9, 2025 at 8:37 AM
The incidence & prevalence of #thyroid #eye disease (TED) have presumably declined in the last decades, possibly related to more attention given to risk factors (eg, smoking) & faster diagnosis & earlier treatment of #Graves’ #hyperthyroidism www.thelancet.com/journals/lan...
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rt-CGM use in women with #gestational #diabetes reduced LGA births, without differences in serious adverse events. The higher-than-expected overall prevalence of SGA infants, possibly related to the tight glycaemic control in our cohort, requires further research tinyurl.com/mpe8tj9m
#CGM #GDM
#CGM #GDM
December 8, 2025 at 3:51 PM
rt-CGM use in women with #gestational #diabetes reduced LGA births, without differences in serious adverse events. The higher-than-expected overall prevalence of SGA infants, possibly related to the tight glycaemic control in our cohort, requires further research tinyurl.com/mpe8tj9m
#CGM #GDM
#CGM #GDM
Although heterozygous #familial #hypercholesterolaemia represents one of the most common monogenic conditions in the general population, homozygous familial hypercholesterolaemia is much rarer, occurring in between one in 160 000 & one in 450 000 individuals www.thelancet.com/journals/lan...
#ASCVD
#ASCVD
December 7, 2025 at 8:45 PM
Although heterozygous #familial #hypercholesterolaemia represents one of the most common monogenic conditions in the general population, homozygous familial hypercholesterolaemia is much rarer, occurring in between one in 160 000 & one in 450 000 individuals www.thelancet.com/journals/lan...
#ASCVD
#ASCVD
#Diabetes-related #foot #ulcers (DFUs) continue to inflict a harmful toll on people with diabetes due to the medical treatments & lifestyle changes needed to heal these lesions or, in the case of healing failure, limb loss through amputation thelancet.com/journals/lan...
#T1D #T2D
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#T1D #T2D
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December 7, 2025 at 5:31 PM
#Diabetes-related #foot #ulcers (DFUs) continue to inflict a harmful toll on people with diabetes due to the medical treatments & lifestyle changes needed to heal these lesions or, in the case of healing failure, limb loss through amputation thelancet.com/journals/lan...
#T1D #T2D
#MedSky #EndoSky
#T1D #T2D
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People with type 2 #diabetes are likely to be more susceptible to adverse health effects from PM2·5, which further amplifies #pollution-related #cardiovascular risk www.thelancet.com/journals/lan...
#T2D #AirPollution #CVD
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#T2D #AirPollution #CVD
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December 7, 2025 at 2:21 PM
People with type 2 #diabetes are likely to be more susceptible to adverse health effects from PM2·5, which further amplifies #pollution-related #cardiovascular risk www.thelancet.com/journals/lan...
#T2D #AirPollution #CVD
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#T2D #AirPollution #CVD
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Although very infrequent, cases of #hypothalamic #obesity are a challenging, often intractable medical condition, that can also help to elucidate mechanisms of obesity and eventually identify therapeutic targets thelancet.com/journals/lan...
#hyperphagia
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#hyperphagia
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December 7, 2025 at 11:13 AM
Although very infrequent, cases of #hypothalamic #obesity are a challenging, often intractable medical condition, that can also help to elucidate mechanisms of obesity and eventually identify therapeutic targets thelancet.com/journals/lan...
#hyperphagia
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#hyperphagia
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Endocrine complications occur in 40–60% of survivors of cancer and include hypothalamic–pituitary disorders, dysregulation of steroid and peptide hormones, and dysregulation of bone and metabolism www.thelancet.com/journals/lan...
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#OpenAccess
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December 6, 2025 at 12:35 PM
Endocrine complications occur in 40–60% of survivors of cancer and include hypothalamic–pituitary disorders, dysregulation of steroid and peptide hormones, and dysregulation of bone and metabolism www.thelancet.com/journals/lan...
#OpenAccess
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#OpenAccess
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Aberrant or ectopic hormone receptors and their ligands
play a much wider role than appreciated in regulating
hormonal secretion via endocrine, paracrine, and
autocrine modes in many endocrine tumours www.thelancet.com/journals/lan...
#GPCRs #endocrine #tumours
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play a much wider role than appreciated in regulating
hormonal secretion via endocrine, paracrine, and
autocrine modes in many endocrine tumours www.thelancet.com/journals/lan...
#GPCRs #endocrine #tumours
#MedSky #EndoSky #OncSky
December 6, 2025 at 12:29 PM
Aberrant or ectopic hormone receptors and their ligands
play a much wider role than appreciated in regulating
hormonal secretion via endocrine, paracrine, and
autocrine modes in many endocrine tumours www.thelancet.com/journals/lan...
#GPCRs #endocrine #tumours
#MedSky #EndoSky #OncSky
play a much wider role than appreciated in regulating
hormonal secretion via endocrine, paracrine, and
autocrine modes in many endocrine tumours www.thelancet.com/journals/lan...
#GPCRs #endocrine #tumours
#MedSky #EndoSky #OncSky
For much of the 20th century, the diagnosis of #adrenal #tumours, defined as enlarged or atypical-appearing adrenal lesions that can be benign or malignant, relied on clinical suspicion of large palpable masses, hormonal manifestations, or autopsy findings www.thelancet.com/journals/lan...
#EndoSky
#EndoSky
December 6, 2025 at 10:05 AM
For much of the 20th century, the diagnosis of #adrenal #tumours, defined as enlarged or atypical-appearing adrenal lesions that can be benign or malignant, relied on clinical suspicion of large palpable masses, hormonal manifestations, or autopsy findings www.thelancet.com/journals/lan...
#EndoSky
#EndoSky
Male #hypogonadism caused by an intrinsic & often irreversible HPT pathology is called organic (also termed classical) hypogonadism. Organic hypogonadism has a straightforward, established diagnostic & treatment pathway
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#testosterone #MensHealth
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#testosterone #MensHealth
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December 4, 2025 at 11:56 AM
Male #hypogonadism caused by an intrinsic & often irreversible HPT pathology is called organic (also termed classical) hypogonadism. Organic hypogonadism has a straightforward, established diagnostic & treatment pathway
www.thelancet.com/journals/lan...
#testosterone #MensHealth
#MedSky #EndoSky
www.thelancet.com/journals/lan...
#testosterone #MensHealth
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New—Social learning theories and metabolic health: the centenary of Bandura's birth thelancet.com/journals/lan...
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December 4, 2025 at 7:03 AM
New—Social learning theories and metabolic health: the centenary of Bandura's birth thelancet.com/journals/lan...
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Portion sizes and caloric inequity: a hidden driver of obesity disparities www.thelancet.com/journals/lan...
#obesity
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#obesity
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December 2, 2025 at 12:30 PM
Portion sizes and caloric inequity: a hidden driver of obesity disparities www.thelancet.com/journals/lan...
#obesity
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#obesity
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