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The central role of recovery of β-cell function in the remission of prediabetes: a prospective cohort study in Canada

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 1d

Has the WHO Model Essential Medicines List lost its way? www.thelancet.com/journals/lan...
#FREE to read

#MedSky #EndoSky

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 2d

Recovery of β-cell function is the dominant determinant of the remission of prediabetes, akin to its role in remission of diabetes but at an earlier point in the natural history of dysglycaemia www.thelancet.com/journals/lan...
#prediabetes #remission

#MedSky #EndoSky

Recovery of β-cell function is the dominant determinant of the remission of prediabetes, akin to its role in remission of diabetes but at an earlier point in the natural history of dysglycaemia.

Type 2 diabetes subtypes classification: a global reckoning with heterogeneity

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 2d

As screening and early treatment for type 1 #diabetes become more widespread, the European action for the Diagnosis of Early Non-clinical Type 1 diabetes For disease Interception (EDENT1FI) consortium highlights the need for clearer, more consistent terminology www.thelancet.com/journals/lan... #T1D

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 2d

A syndromic framework grounded in molecular pathophysiology could ultimately reorient #diabetes care towards precise, stratified risk prediction, personalised prevention, and targeted therapy www.thelancet.com/journals/lan... #T2D
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For decades, type 2 diabetes has been managed as a monolithic condition, defined by hyperglycaemia and treated via uniform, stepwise algorithms. Although operationally convenient, this practice increa...

Experience evolves into evidence in the new MEN1 guidelines

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The Lancet @thelancet.com · 3d

Incretin-based therapies are becoming a core component of diabetes care.

By linking digestion, metabolism, & cardiovascular function, incretin-based therapies can help reduce morbidity & mortality.

Find out more in @thelancetendo.bsky.social: tinyurl.com/dvtv7j28

Figure showing effects of incretins on digestion and the possible resulting clinical benefits. Copyright: 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 4d

Joint Linked Comment by Adrian F Daly:
Experience evolves into evidence in the new MEN1 guidelines thelancet.com/journals/lan...
#MEN1
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Nearly a quarter of a century has passed since the publication of the first clinical practice guideline on multiple endocrine neoplasia type 1 (MEN1) in 2001, which followed the identification of the ...

Treatments for MEN1-associated endocrine tumours: three systematic reviews and a meta-analysis

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 4d

Treatments for MEN1-associated endocrine tumours: three systematic reviews and a meta-analysis thelancet.com/journals/lan...
#MEN1
#OpenAccess

#MedSky #EndoSky #OncSky

In patients with MEN1, subtotal parathyroidectomy achieved greater reductions in persistence and recurrence of primary hyperparathyroidism than less than subtotal parathyroidectomy; for non-functionin...

Multiple endocrine neoplasia type 1 (MEN1): recommendations and guidelines for best practice

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 4d

Multiple endocrine neoplasia type 1 (MEN1): recommendations and guidelines for best practice thelancet.com/journals/lan...
#MEN1
#FREE to read with registration (also FREE)

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Multiple endocrine neoplasia type 1 (MEN1) is characterised by combined occurrence of parathyroid tumours, duodenopancreatic neuroendocrine tumours, and anterior pituitary adenomas. Some patients migh...

Glucocorticoid-induced osteoporosis: novel concepts and clinical implications

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 5d

Fragility fractures remain a common & serious
complication of long-term oral glucocorticoid therapy
that can affect all skeletal sites although the spine is
particularly prone to fractures owing to its high proportion
of trabecular bone www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky

Despite advances in targeted therapies, treatment with glucocorticoids remains a mainstay in the management of various immune-mediated diseases. High cumulative doses of exogenous glucocorticoids lead...

Peripheral CB1 receptor blockade for treatment of obesity

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 5d

Kishore M Gadde & colleagues comment on:
Peripheral CB1 receptor blockade for treatment of obesity www.thelancet.com/journals/lan...
#monlunabant #obesity #metabolic #syndrome

#MedSky #EndoSky

The endocannabinoid system—comprising cannabinoid receptors (CB1 and CB2), lipid-derived ligands, and metabolic enzymes—plays a major role in regulating energy homoeostasis.1 CB1 receptors are abundan...

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 5d

The implications of this trial, combined with existing evidence, suggest that #monlunabant has potential as a novel treatment option for people with #obesity and #metabolic #syndrome, if a safe and effective therapeutic window can be established www.thelancet.com/journals/lan...

#MedSky #EndoSky

Prolactin-secreting adenomas: pathogenesis, diagnosis, and management

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 5d

The evolutionary basis for type 2 #diabetes prevalence in the Arabian Peninsula www.thelancet.com/journals/lan... #T2D

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 7d

#Hyperprolactinaemia can result from physiological causes, pharmacological agents, or pathological conditions such as #prolactin-secreting #pituitary #adenomas and other pituitary stalk-compressing masses
www.thelancet.com/journals/lan...
#prolactinomas

#MedSky #EndoSky #OncSky

Hyperprolactinaemia can result from physiological causes, pharmacological agents, or pathological conditions such as prolactin-secreting pituitary adenomas and other pituitary stalk-compressing masses...

The unique signature of tyrosine kinase inhibitor-induced hypothyroidism

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 8d

As the targets of tyrosine kinase inhibitors (#TKIs) also have roles in many physiological processes, TKIs can cause multiple treatment-related adverse events, among which an increase in serum #thyroid stimulating hormone (TSH) concentrations frequently occurs www.thelancet.com/journals/lan... .

Tyrosine kinase inhibitors (TKIs) are anti-cancer agents that inhibit the activity of oncogenic protein kinases. Thyroid hormone abnormalities are common during treatment with TKIs, typically manifest...

Minimum effective low dose of antithymocyte globulin in people aged 5–25 years with recent-onset stage 3 type 1 diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlle...

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The Lancet @thelancet.com · 8d

Tune in on October 3rd for the official launch of the 2025 EAT-Lancet Commission. A major update to the science and what it means for our global food system.

🔗 Register for the livestream here: bit.ly/3Kg9SW8

A promotional card for the 2025 EAT-Lancet Commission, officially launching on October 3 at Stockholm Food Forum.

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The Lancet @thelancet.com · 9d

Minimum effective low dose of antithymocyte globulin in people aged 5–25 years with recent-onset stage 3 type 1 diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlled, adaptive dose-ranging trial tinyurl.com/bdenbtyb

In young people with recent-onset, clinical type 1 diabetes, 2·5 mg/kg and 0·5 mg/kg ATG reduced loss of β-cell function, showing the potential of an affordable, repurposed agent, ATG, in a low and sa...

tinyurl.com

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 9d

The gut–bone axis: implications of gut hormone-based therapies for bone health thelancet.com/journals/lan...
#GLP-1 #GIP #incretins #weightloss #obesity #overweight #Bonehealth #osteoporosis

#MedSky #EndoSky #RheumSky

The gut–bone axis: implications of gut hormone-based therapies for bone health

Historical trends and future projections of the number of people with overweight and obesity suggest alarming parallel increases in serious and potentially fatal comorbidities, particularly type 2 dia...

Peripheral CB1 receptor blockade for treatment of obesity

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 9d

Also read the Linked Comment:
Peripheral CB1 receptor blockade for treatment of obesity thelancet.com/journals/lan...
#obesity #MetabolicSyndrome

#MedSky #EndoSky

The endocannabinoid system—comprising cannabinoid receptors (CB1 and CB2), lipid-derived ligands, and metabolic enzymes—plays a major role in regulating energy homoeostasis.1 CB1 receptors are abundan...

Efficacy and safety of monlunabant in adults with obesity and metabolic syndrome: a double-blind, randomised, placebo-controlled, phase 2a trial

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 9d

New—Efficacy and safety of #monlunabant in adults with obesity and metabolic syndrome: a double-blind, randomised, placebo-controlled, phase 2a trial thelancet.com/journals/lan...
#obesity #MetabolicSyndrome

#MedSky #EndoSky

Participants receiving monlunabant showed statistically significant and clinically meaningful weight loss compared with those receiving placebo for all tested doses. Only slightly greater weight loss ...

World Heart Day: diabetes and cardiovascular risk

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 10d

High cumulative doses of exogenous #glucocorticoids lead to a spectrum of side-effects, in particular increased #fracture risk. Fragility fractures might result in immobility, frequent admission to hospitals, and loss of quality of life thelancet.com/journals/lan...
#OpenAccess

#MedSky #EndoSky

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 10d

New Editorial:
World Heart Day: diabetes and cardiovascular risk www.thelancet.com/journals/lan...
#diabetes #CVD
#WorldHeartDay
#FREE to read

#MedSky #EndoSky #CardioSky

Cardiovascular disease is one of the leading causes of death globally. Tragically, as many as 80% of heart disease and stroke cases could be avoided through prevention. For people with diabetes, the r...

Bone health in adults with obesity before and after interventions to promote weight loss

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 11d

#Fractures affect a substantial proportion of people with #obesity and result from reduced #bone strength relative to increased mechanical loading, together with an increased risk of #falls www.thelancet.com/journals/lan...
#weightloss #BariatricSurgery #GLP-1 receptor agonists

#MedSky #EndoSky

Obesity and its associated comorbidities constitute a serious and growing public health burden. Fractures affect a substantial proportion of people with obesity and result from reduced bone strength r...

Classifying a distinct form of diabetes in lean individuals with a history of undernutrition: an international consensus statement

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 11d

Published in @lancetgh.bsky.social
Classifying a distinct form of #diabetes in lean individuals with a history of undernutrition: an international consensus statement www.thelancet.com/journals/lan...
#OpenAccess

#MedSky #EndoSky

Since 1955, a form of diabetes in lean, young (BMI <18·5 kg/m2, age <30 years) individuals with a history suggestive of undernutrition from before birth and throughout childhood has been described in ...

Glucocorticoid-induced osteoporosis: novel concepts and clinical implications

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 12d

Fragility #fractures remain a common and serious
complication of long-term oral #glucocorticoid therapy
that might affect all skeletal sites, although the spine is
particularly prone to fractures owing to its high proportion
of trabecular bone www.thelancet.com/journals/lan...
#OpenAccess

#EndoSky

Despite advances in targeted therapies, treatment with glucocorticoids remains a mainstay in the management of various immune-mediated diseases. High cumulative doses of exogenous glucocorticoids lead...

International Federation for the Surgery of Obesity statement on metabolic bariatric surgery after pharmacotherapy-induced weight loss in clinical obesity

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 13d

Sporadic #prolactinomas are the most common functioning #pituitary #adenomas, with a female predominance during reproductive years. In men, these adenomas are usually larger and more aggressive www.thelancet.com/journals/lan...
#hyperprolactinaemia

#MedSky #EndoSky #OncSky

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The Lancet @thelancet.com · 14d

Cancer deaths expected to rise to over 18 million in 2050—an increase of nearly 75% from 2024, study forecasts.

Explore the data ▶️ tinyurl.com/5n7dfnws @ihmeuw.bsky.social #NCDs

Figure: Global age-specific cancer (A) incidence and (B) mortality in 2023 for all sexes combined. Results are presented by 5-year age group. Left panels present age-specific incidence and mortality rates. Right panels present age-specific new case and death proportions. Copyright: 2025 Elsevier Ltd. All rights are reserved.

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 14d

International Federation for the Surgery of Obesity statement on metabolic bariatric surgery after pharmacotherapy-induced weight loss in clinical obesity www.thelancet.com/journals/lan...
#obesity
#FREE to read with registration (also FREE)

#MedSky #EndoSky

Clinical obesity is a chronic systemic disease characterised by alterations in the function of tissues, organs, physical ability, or a combination of these due to excess adiposity, which can increase ...