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Effects of empagliflozin on conventional and exploratory acute and chronic kidney outcomes: an individual participant-level meta-analysis

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 13h

New—Effects of #empagliflozin on conventional and exploratory acute and chronic #kidney outcomes: an individual participant-level meta-analysis thelancet.com/journals/lan...
#SGLT2 inhibitor #CKD
#OpenAccess

#MedSky #EndoSky #RenalSky

SGLT2 inhibition reduces risk of acute and chronic kidney outcomes irrespective of the size of the acute dip in eGFR. Kidney benefits are evident irrespective of diabetes status, heart failure status,...

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 20h

#Hyperprolactinaemia can result from dopamine antagonist drug effects and reduced prolactin clearance with liver or kidney disease with loss of feedback regulation thelancet.com/journals/lan...
#prolactinoma #pituitary #adenoma

#MedSky #EndoSky

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 23h

There is substantial heterogeneity in the contributors to the pathophysiology of #MASLD, which might influence its rate of progression, its relationship with #cardiometabolic diseases, and the response to therapy www.thelancet.com/journals/lan...
#OpenAccess

#MedSky #EndoSky #LiverSky #HepSky

Dissection of type 2 diabetes: a genetic perspective

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 1d

Although obesity & a sedentary lifestyle are considerable contributors, research over the last 25 years has shown that type 2 #diabetes develops on a predisposing #genetic background, with family & twin studies indicating considerable heritability (ie, 31–72%) www.thelancet.com/journals/lan...
#T2D

Diabetes is a leading cause of global mortality and disability, and its economic burden is substantial. This Review focuses on type 2 diabetes, which makes up 90–95% of all diabetes cases. Type 2 diab...

Re-evaluating the concept of remission in type 2 diabetes: a call for patient-centric approaches

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 1d

Controlling weight and cardiovascular risk factors is paramount in type 2 #diabetes management; however, the definition and feasibility of #remission warrant closer examination www.thelancet.com/journals/lan...
#T2D

#MedSky #EndoSky #CardioSky

Controlling weight and cardiovascular risk factors is paramount in type 2 diabetes management; however, the definition and feasibility of remission warrant closer examination. Type 2 diabetes remissio...

Glucocorticoid-induced osteoporosis: novel concepts and clinical implications

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The Lancet Gastroenterology & Hepatology @lancetgastrohep.bsky.social · 2d

Our latest issue is out now at www.thelancet.com/gastrohep!

Content includes #obesity, #MASLD, #FMT for #Cdiff #viralhepatitis, #cirrhosis, #DGBI & more!

#GastroSky #LiverSky #MedSky

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The Lancet @thelancet.com · 3d

The treatment of type 1 diabetes is entering a transformative era.

A recent Review explores three paradigm-shifting developments poised to transform type 1 diabetes treatment: tinyurl.com/2834ymk7

Figure showing the production and transplantation of β cells derived from embryonic or induced pluripotent stem cells. Copyright: 2025 The Author(s). Published by Elsevier Ltd. CC BY 4.0.

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 3d

#Glucocorticoid treatment has become the most common drug-induced form of #osteoporosis because of its broad therapeutic use for various inflammatory & haematological diseases & its pivotal role in transplantation medicine www.thelancet.com/journals/lan...
#OpenAccess

#MedSky #EndoSky #RheumSky

Despite advances in targeted therapies, treatment with glucocorticoids remains a mainstay in the management of various immune-mediated diseases. High cumulative doses of exogenous glucocorticoids lead...

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 3d

Has the WHO Model Essential Medicines List lost its way? www.thelancet.com/journals/lan...
#FREE to read

#MedSky #EndoSky

The central role of recovery of β-cell function in the remission of prediabetes: a prospective cohort study in Canada

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 4d

Recovery of β-cell function is the dominant determinant of the remission of prediabetes, akin to its role in remission of diabetes but at an earlier point in the natural history of dysglycaemia www.thelancet.com/journals/lan...
#prediabetes #remission

#MedSky #EndoSky

Recovery of β-cell function is the dominant determinant of the remission of prediabetes, akin to its role in remission of diabetes but at an earlier point in the natural history of dysglycaemia.

Type 2 diabetes subtypes classification: a global reckoning with heterogeneity

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 4d

As screening and early treatment for type 1 #diabetes become more widespread, the European action for the Diagnosis of Early Non-clinical Type 1 diabetes For disease Interception (EDENT1FI) consortium highlights the need for clearer, more consistent terminology www.thelancet.com/journals/lan... #T1D

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 4d

A syndromic framework grounded in molecular pathophysiology could ultimately reorient #diabetes care towards precise, stratified risk prediction, personalised prevention, and targeted therapy www.thelancet.com/journals/lan... #T2D
#FREE to read with registration (also FREE)

#MedSky #EndoSky

For decades, type 2 diabetes has been managed as a monolithic condition, defined by hyperglycaemia and treated via uniform, stepwise algorithms. Although operationally convenient, this practice increa...

Experience evolves into evidence in the new MEN1 guidelines

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The Lancet @thelancet.com · 4d

Incretin-based therapies are becoming a core component of diabetes care.

By linking digestion, metabolism, & cardiovascular function, incretin-based therapies can help reduce morbidity & mortality.

Find out more in @thelancetendo.bsky.social: tinyurl.com/dvtv7j28

Figure showing effects of incretins on digestion and the possible resulting clinical benefits. Copyright: 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 5d

Joint Linked Comment by Adrian F Daly:
Experience evolves into evidence in the new MEN1 guidelines thelancet.com/journals/lan...
#MEN1
#FREE to read with registration (also FREE)

#MedSky #EndoSky #OncSky

Nearly a quarter of a century has passed since the publication of the first clinical practice guideline on multiple endocrine neoplasia type 1 (MEN1) in 2001, which followed the identification of the ...

Treatments for MEN1-associated endocrine tumours: three systematic reviews and a meta-analysis

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 5d

Treatments for MEN1-associated endocrine tumours: three systematic reviews and a meta-analysis thelancet.com/journals/lan...
#MEN1
#OpenAccess

#MedSky #EndoSky #OncSky

In patients with MEN1, subtotal parathyroidectomy achieved greater reductions in persistence and recurrence of primary hyperparathyroidism than less than subtotal parathyroidectomy; for non-functionin...

Multiple endocrine neoplasia type 1 (MEN1): recommendations and guidelines for best practice

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 5d

Multiple endocrine neoplasia type 1 (MEN1): recommendations and guidelines for best practice thelancet.com/journals/lan...
#MEN1
#FREE to read with registration (also FREE)

#MedSky #EndoSky #OncSky

Multiple endocrine neoplasia type 1 (MEN1) is characterised by combined occurrence of parathyroid tumours, duodenopancreatic neuroendocrine tumours, and anterior pituitary adenomas. Some patients migh...

Glucocorticoid-induced osteoporosis: novel concepts and clinical implications

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 7d

Fragility fractures remain a common & serious
complication of long-term oral glucocorticoid therapy
that can affect all skeletal sites although the spine is
particularly prone to fractures owing to its high proportion
of trabecular bone www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky

Despite advances in targeted therapies, treatment with glucocorticoids remains a mainstay in the management of various immune-mediated diseases. High cumulative doses of exogenous glucocorticoids lead...

Peripheral CB1 receptor blockade for treatment of obesity

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 7d

Kishore M Gadde & colleagues comment on:
Peripheral CB1 receptor blockade for treatment of obesity www.thelancet.com/journals/lan...
#monlunabant #obesity #metabolic #syndrome

#MedSky #EndoSky

The endocannabinoid system—comprising cannabinoid receptors (CB1 and CB2), lipid-derived ligands, and metabolic enzymes—plays a major role in regulating energy homoeostasis.1 CB1 receptors are abundan...

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 7d

The implications of this trial, combined with existing evidence, suggest that #monlunabant has potential as a novel treatment option for people with #obesity and #metabolic #syndrome, if a safe and effective therapeutic window can be established www.thelancet.com/journals/lan...

#MedSky #EndoSky

Prolactin-secreting adenomas: pathogenesis, diagnosis, and management

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 7d

The evolutionary basis for type 2 #diabetes prevalence in the Arabian Peninsula www.thelancet.com/journals/lan... #T2D

#MedSky #EndoSky

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 9d

#Hyperprolactinaemia can result from physiological causes, pharmacological agents, or pathological conditions such as #prolactin-secreting #pituitary #adenomas and other pituitary stalk-compressing masses
www.thelancet.com/journals/lan...
#prolactinomas

#MedSky #EndoSky #OncSky

Hyperprolactinaemia can result from physiological causes, pharmacological agents, or pathological conditions such as prolactin-secreting pituitary adenomas and other pituitary stalk-compressing masses...

The unique signature of tyrosine kinase inhibitor-induced hypothyroidism

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 9d

As the targets of tyrosine kinase inhibitors (#TKIs) also have roles in many physiological processes, TKIs can cause multiple treatment-related adverse events, among which an increase in serum #thyroid stimulating hormone (TSH) concentrations frequently occurs www.thelancet.com/journals/lan... .

Tyrosine kinase inhibitors (TKIs) are anti-cancer agents that inhibit the activity of oncogenic protein kinases. Thyroid hormone abnormalities are common during treatment with TKIs, typically manifest...

Minimum effective low dose of antithymocyte globulin in people aged 5–25 years with recent-onset stage 3 type 1 diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlle...

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The Lancet @thelancet.com · 10d

Tune in on October 3rd for the official launch of the 2025 EAT-Lancet Commission. A major update to the science and what it means for our global food system.

🔗 Register for the livestream here: bit.ly/3Kg9SW8

A promotional card for the 2025 EAT-Lancet Commission, officially launching on October 3 at Stockholm Food Forum.

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The Lancet @thelancet.com · 11d

Minimum effective low dose of antithymocyte globulin in people aged 5–25 years with recent-onset stage 3 type 1 diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlled, adaptive dose-ranging trial tinyurl.com/bdenbtyb

In young people with recent-onset, clinical type 1 diabetes, 2·5 mg/kg and 0·5 mg/kg ATG reduced loss of β-cell function, showing the potential of an affordable, repurposed agent, ATG, in a low and sa...

tinyurl.com

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 11d

The gut–bone axis: implications of gut hormone-based therapies for bone health thelancet.com/journals/lan...
#GLP-1 #GIP #incretins #weightloss #obesity #overweight #Bonehealth #osteoporosis

#MedSky #EndoSky #RheumSky

The gut–bone axis: implications of gut hormone-based therapies for bone health

Historical trends and future projections of the number of people with overweight and obesity suggest alarming parallel increases in serious and potentially fatal comorbidities, particularly type 2 dia...

Peripheral CB1 receptor blockade for treatment of obesity

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 11d

Also read the Linked Comment:
Peripheral CB1 receptor blockade for treatment of obesity thelancet.com/journals/lan...
#obesity #MetabolicSyndrome

#MedSky #EndoSky

The endocannabinoid system—comprising cannabinoid receptors (CB1 and CB2), lipid-derived ligands, and metabolic enzymes—plays a major role in regulating energy homoeostasis.1 CB1 receptors are abundan...

Efficacy and safety of monlunabant in adults with obesity and metabolic syndrome: a double-blind, randomised, placebo-controlled, phase 2a trial

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 11d

New—Efficacy and safety of #monlunabant in adults with obesity and metabolic syndrome: a double-blind, randomised, placebo-controlled, phase 2a trial thelancet.com/journals/lan...
#obesity #MetabolicSyndrome

#MedSky #EndoSky

Participants receiving monlunabant showed statistically significant and clinically meaningful weight loss compared with those receiving placebo for all tested doses. Only slightly greater weight loss ...

World Heart Day: diabetes and cardiovascular risk

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 11d

High cumulative doses of exogenous #glucocorticoids lead to a spectrum of side-effects, in particular increased #fracture risk. Fragility fractures might result in immobility, frequent admission to hospitals, and loss of quality of life thelancet.com/journals/lan...
#OpenAccess

#MedSky #EndoSky

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 12d

New Editorial:
World Heart Day: diabetes and cardiovascular risk www.thelancet.com/journals/lan...
#diabetes #CVD
#WorldHeartDay
#FREE to read

#MedSky #EndoSky #CardioSky

Cardiovascular disease is one of the leading causes of death globally. Tragically, as many as 80% of heart disease and stroke cases could be avoided through prevention. For people with diabetes, the r...