The Lancet Diabetes & Endocrinology
@thelancetendo.bsky.social
Your leading source of international, cutting-edge research, review, and opinion in clinical #diabetes and #endocrinology. IF=41·8.
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The Lancet is a weekly peer-reviewed general medical journal, founded in England in 1823. It is one of the world's highest-impact academic journals and also one of the oldest medical journals still in publication. .. more
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Read our January 2026 Issue, featuring adrenal tumour imaging, type 2 diabetes, heart failure, atherosclerotic cardiovascular disease, cancer, gestational diabetes, CGM, type 1 diabetes, obesity, ultra-processed foods & much more tinyurl.com/mwfu4c6m
#MedSky #EndoSky #CardioSky #OncSky #GastroSky
#MedSky #EndoSky #CardioSky #OncSky #GastroSky
Metabolic dysfunction-associated steatotic liver disease: heterogeneous pathomechanisms and effectiveness of metabolism-based treatment
www.thelancet.com/journals/lan...
#MASLD #obesity #lipodystrophy
#OpenAccess
#MedSky #EndoSky #LiverSky
www.thelancet.com/journals/lan...
#MASLD #obesity #lipodystrophy
#OpenAccess
#MedSky #EndoSky #LiverSky
Incretin hormones—glucagon-like peptide-1 (GLP-1) & glucose-dependent insulinotropic peptide (GIP)—act as a critical link connecting #digestion, #metabolism, & #cardiovascular function, supporting physiological adaptations to nutrient intake thelancet.com/journals/lan...
#incretins
#MedSky #EndoSky
#incretins
#MedSky #EndoSky
Defining prediabetes remission as a distinct prevention endpoint
Current diabetes prevention concepts focus on halting the progression of prediabetes
to type 2 diabetes. The idea that the risk profile can be turned in the other direction
is a more optimistic notion...
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Prediabetes remission is a distinct and actionable endpoint that redirects the disease trajectory towards health, rather than merely slowing the decline to β-cell dysfunction and type 2 diabetes www.thelancet.com/journals/lan...
#prediabetes #remission
#FREE to read with registration (also FREE)
#prediabetes #remission
#FREE to read with registration (also FREE)
Preventing cardiovascular risk in people with prediabetes
That it is possible to prevent or at least slow the onset of type 2 diabetes in people
with prediabetes is well established.1 It is also known that prediabetes increases
the risk for an impaired cardi...
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Linked Comment by Linda Mellbin & Lars Rydén:
Preventing cardiovascular risk in people with prediabetes www.thelancet.com/journals/lan...
#prediabetes #remission #CVD
#FREE to read with registration (also FREE)
#MedSky #EndoSky #CardioSky
Preventing cardiovascular risk in people with prediabetes www.thelancet.com/journals/lan...
#prediabetes #remission #CVD
#FREE to read with registration (also FREE)
#MedSky #EndoSky #CardioSky
Prediabetes remission and cardiovascular morbidity and mortality: post-hoc analyses from the Diabetes Prevention Program Outcome study and the DaQing Diabetes Prevention Outcome study
Reaching prediatbetes remission is linked to a decades-long benefit, halving the risk
of cardiovascular death or hospitalisation for heart failure in diverse populations.
Targeting remission might rep...
www.thelancet.com
Reaching #prediabetes #remission is linked to a decades-long benefit, halving the risk of #cardiovascular death or hospitalisation for heart failure in diverse populations. Targeting remission might represent a new approach to cardiovascular prevention www.thelancet.com/journals/lan...
#OpenAccess
#OpenAccess
Glucocorticoid-induced osteoporosis: novel concepts and clinical implications
Despite advances in targeted therapies, treatment with glucocorticoids remains a mainstay
in the management of various immune-mediated diseases. High cumulative doses of exogenous
glucocorticoids lead...
thelancet.com
Individuals on long-term oral #glucocorticoid treatment display an estimated prevalence of #osteoporosis or fractures as high as 30–50%, rendering glucocorticoid therapy the most common cause of secondary and iatrogenic osteoporosis thelancet.com/journals/lan...
#MedSky #EndoSky #RheumSky
#MedSky #EndoSky #RheumSky
Life stage transitions for people with type 1 diabetes
Type 1 diabetes affects individuals of all ages, with different clinical priorities
and support needs at different stages of life. In this Personal View, we define the
two major transitions that occur...
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With more people with type 1 #diabetes living into older adulthood, new research and clinical-care models that consider multiple important life stage transitions and their effect on type 1 diabetes care and self-management are needed www.thelancet.com/journals/lan... #T1D
#MedSky #EndoSky
#MedSky #EndoSky
Managing adults with screen-detected islet autoantibody positivity: a pragmatic framework
New disease-modifying therapies, such as teplizumab, offer opportunities to delay
the clinical onset of type 1 diabetes but require islet autoantibody screening to
identify individuals at increased ri...
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In adults with #islet #autoantibody positivity, the lower risk of progression to type 1 #diabetes compared with children, combined with the high background prevalence of mild non-autoimmune dysglycaemia, presents substantial challenges for clinical management www.thelancet.com/journals/lan... #T1D
Reposted by The Lancet Diabetes Endocrinology
The Lancet
@thelancet.com
· 3d
Heterozygous familial hypercholesterolemia is a common genetic condition characterised by high LDL cholesterol levels from a young age.
A Review in @thelancetendo.bsky.social discusses the latest knowledge familial hypercholesterolaemia & its unmet clinical needs: spkl.io/63320AiBFu
A Review in @thelancetendo.bsky.social discusses the latest knowledge familial hypercholesterolaemia & its unmet clinical needs: spkl.io/63320AiBFu
The prevalence of overweight and obesity in China has continued to increase over the last decade, with mounting health and economic consequences www.thelancet.com/journals/lan...
#obesity #China
#MedSky #EndoSky
#obesity #China
#MedSky #EndoSky
Continuous ketone monitoring for people with diabetes: international expert recommendations on the application of a new technology
The ability to reduce the risk of developing diabetic ketoacidosis (DKA) remains a
major care gap for people with diabetes, particularly those on intensive insulin therapy.
The anticipated availabilit...
www.thelancet.com
New in the January Issue:
Continuous ketone monitoring for people with #diabetes: international expert recommendations on the application of a new technology www.thelancet.com/journals/lan...
#FREE to read with registration (also FREE)
#MedSky #EndoSky
Continuous ketone monitoring for people with #diabetes: international expert recommendations on the application of a new technology www.thelancet.com/journals/lan...
#FREE to read with registration (also FREE)
#MedSky #EndoSky
Staging prediabetes and type 2 diabetes: the time to start is now
Impaired glucose tolerance and impaired fasting glucose have long been recognised
as risk factors for type 2 diabetes development. The term prediabetes was introduced
by the American Diabetes Associat...
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New in the January Issue:
Staging #prediabetes and type 2 #diabetes: the time to start is now www.thelancet.com/journals/lan... #T2D
#MedSky #EndoSky
Staging #prediabetes and type 2 #diabetes: the time to start is now www.thelancet.com/journals/lan... #T2D
#MedSky #EndoSky
Futility of plasmapheresis, insulin in normoglycaemic individuals, or heparin in the treatment of #hypertriglyceridaemia-induced acute #pancreatitis www.thelancet.com/journals/lan...
#triglycerides
#MedSky #EndoSky #GastroSky
#triglycerides
#MedSky #EndoSky #GastroSky
The incidence & prevalence of #thyroid #eye disease (TED) have presumably declined in the last decades, possibly related to more attention given to risk factors (eg, smoking) & faster diagnosis & earlier treatment of #Graves’ #hyperthyroidism www.thelancet.com/journals/lan...
#MedSky #EndoSky
#MedSky #EndoSky
rt-CGM use in women with #gestational #diabetes reduced LGA births, without differences in serious adverse events. The higher-than-expected overall prevalence of SGA infants, possibly related to the tight glycaemic control in our cohort, requires further research tinyurl.com/mpe8tj9m
#CGM #GDM
#CGM #GDM
Reposted by The Lancet Diabetes Endocrinology
The Lancet
@thelancet.com
· 6d
In high-risk pregnancies, there is no reliable intervention to reduce term pre-eclampsia.
A new study investigated the effect of screening for pre-eclampsia risk at 36 weeks' gestation and offering risk-stratified, planned, early-term birth: spkl.io/63324A9z06
A new study investigated the effect of screening for pre-eclampsia risk at 36 weeks' gestation and offering risk-stratified, planned, early-term birth: spkl.io/63324A9z06
Definition and diagnostic criteria of clinical obesity
Current BMI-based measures of obesity can both underestimate and overestimate adiposity
and provide inadequate information about health at the individual level, which undermines
medically-sound approa...
www.thelancet.com
Current BMI-based measures of #obesity can both underestimate and overestimate adiposity and provide inadequate information about health at the individual level, which undermines medically-sound approaches to health care and policy www.thelancet.com/journals/lan...
#FREE to read w/reg (also FREE)
#FREE to read w/reg (also FREE)
Although heterozygous #familial #hypercholesterolaemia represents one of the most common monogenic conditions in the general population, homozygous familial hypercholesterolaemia is much rarer, occurring in between one in 160 000 & one in 450 000 individuals www.thelancet.com/journals/lan...
#ASCVD
#ASCVD
#Diabetes-related #foot #ulcers (DFUs) continue to inflict a harmful toll on people with diabetes due to the medical treatments & lifestyle changes needed to heal these lesions or, in the case of healing failure, limb loss through amputation thelancet.com/journals/lan...
#T1D #T2D
#MedSky #EndoSky
#T1D #T2D
#MedSky #EndoSky
People with type 2 #diabetes are likely to be more susceptible to adverse health effects from PM2·5, which further amplifies #pollution-related #cardiovascular risk www.thelancet.com/journals/lan...
#T2D #AirPollution #CVD
#MedSky #EndoSky
#T2D #AirPollution #CVD
#MedSky #EndoSky
Although very infrequent, cases of #hypothalamic #obesity are a challenging, often intractable medical condition, that can also help to elucidate mechanisms of obesity and eventually identify therapeutic targets thelancet.com/journals/lan...
#hyperphagia
#MedSky #EndoSky
#hyperphagia
#MedSky #EndoSky
Endocrine complications occur in 40–60% of survivors of cancer and include hypothalamic–pituitary disorders, dysregulation of steroid and peptide hormones, and dysregulation of bone and metabolism www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky #OncSky
#OpenAccess
#MedSky #EndoSky #OncSky
Aberrant or ectopic hormone receptors and their ligands
play a much wider role than appreciated in regulating
hormonal secretion via endocrine, paracrine, and
autocrine modes in many endocrine tumours www.thelancet.com/journals/lan...
#GPCRs #endocrine #tumours
#MedSky #EndoSky #OncSky
play a much wider role than appreciated in regulating
hormonal secretion via endocrine, paracrine, and
autocrine modes in many endocrine tumours www.thelancet.com/journals/lan...
#GPCRs #endocrine #tumours
#MedSky #EndoSky #OncSky
Reposted by The Lancet Diabetes Endocrinology
The Lancet
@thelancet.com
· 8d
Eloralintide, a selective amylin receptor agonist for the treatment of obesity: a 48-week phase 2, multicentre, double-blind, randomised, placebo-controlled trial spkl.io/63325AgSD7
For much of the 20th century, the diagnosis of #adrenal #tumours, defined as enlarged or atypical-appearing adrenal lesions that can be benign or malignant, relied on clinical suspicion of large palpable masses, hormonal manifestations, or autopsy findings www.thelancet.com/journals/lan...
#EndoSky
#EndoSky
Reposted by Nicola J. Cooper, The Lancet Diabetes Endocrinology
The Lancet
@thelancet.com
· 9d
The rise of ultra-processed foods is damaging public health, fuelling chronic diseases worldwide, and deepening health inequalities.
Urgent, coordinated global action is needed to address the UPF challenge.
Find out more in an Editorial ➡️ spkl.io/63327AgUC1
Urgent, coordinated global action is needed to address the UPF challenge.
Find out more in an Editorial ➡️ spkl.io/63327AgUC1