Welcome and thank you for participating in this survey! We are the researchers in Boettcher's group at University of Vienna, who are developing the new antibiotic specifically targeting N. gonorrhoeae...

There is much interest in the development of dietary supplements that selectively promote the growth of beneficial gut bacteria. The selectivity of many candidate prebiotics has, however, not been ...

Pseudomonas aeruginosa-derived 2-nonyl-4-quinolone N-oxide exerts bactericidal effects on Neisseria gonorrhoea via zeta1–epsilon1 toxin–antitoxin activation in vitro and abrogates experimental infecti...

Pseudomonas syringae can detect and kill microbial predators via a chemical radar (Cra), which also allows the bacterium to infect plants despite predation pressure.

Pseudomonas aeruginosa-derived 2-nonyl-4-quinolone N-oxide exerts bactericidal effects on Neisseria gonorrhoea via zeta1–epsilon1 toxin–antitoxin activation in vitro and abrogates experimental infecti...

This novel antibiotic activates an existing "suicide" mechanism in gonococci

Neuartiges Antibiotikum aktiviert einen in den Gonokokken bereits vorhandenen Selbsttötungsmechanismus

CEO Jonathan Solomon explains the significance of BX211—a phage therapy for diabetic foot osteomyelitis—in developing a new precision medicine modality.

2-Alkyl-4(1H)-quinolones play a key role in bacterial communication, regulating biofilm formation, and virulence. Their antimicrobial properties also support bacterial survival and interspecies competition in microbial communities. In addition to the human pathogen Pseudomonas aeruginosa various species of Burkholderia and Pseudoalteromonas are known to produce 2-alkyl-4(1H)-quinolones. However, the evolutionary relationships of their biosynthetic gene clusters remain largely unexplored. To address this, we investigated the phylogeny of 2-alkyl-4(1H)-quinolone biosynthetic gene clusters, leading to the discovery of Chitinivorax as a fourth genus capable of producing 2-alkyl-4(1H)-quinolones, expanding our knowledge of the diversity of bacteria involved in quinolone-biosynthesis.

Open positions

We are delighted to announce that Jillian Petersen has been appointed Full Professor (§ 99/4) at the Center for Microbiology and Environmental Systems Science (CeMESS). This appointment marks an excit...