Excited to have this work published. With @trceklab.bsky.social we show that RNA structure impedes intermolecular base pairing in germ granule.

This finding suggests that RNA structures and dynamics have important effects on the ion cloud, which IS the RNA spatial fingerprint. Unstructured RNAs thus can play a role of a recruiter of molecular partners using long-ranged interactions, leaving stable interactions for folded domains.

Ca ions prefer to bind directly to phosphate without water mediation, while Mg ions bind to RNA fully hydrated. This means the Mg ion cloud is much more extended compared to Ca cloud.

Ecstatic to have our lab's first paper published on JPCL @pubs.acs.org. We showed the ion atmospheres of unstructured RNAs extend farther into solution compared to folded structures. pubs.acs.org/doi/10.1021/...

🚨 We’re looking for a curious mind to join our lab at the NIH!
Passionate about #RNA biology, #MachineLearning, and the #genomics of #aging?

Interested in a postdoc or a PhD research visit at NIH? Let’s connect.
📩 DM or email for details!

#Bioinformatics #AI #ComputationalBiology

Are you looking for a faculty job? We are hiring in my department at Roswell Park NOW. Contact me for details as I await the formal ad. (Please RT.)

Kudos to Hiranmay and Peter for spearheading it!

Excited to share our lab's preprint! We found that flexible RNAs have much broadened ion atmospheres than structured RNAs. This leads us to speculate the implications on molecular recognition and phase behavior. Please check full text for other interesting details www.biorxiv.org/content/10.1...

ACTION ITEM-----ACTION ITEM

Implementation of Schedule F

This is what a lot of us have been worried about.

This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.

BUT THERE IS A COMMENT PERIOD...

1/n

More from the Washington Post (and this one is a doozy) regarding the President's Budget. Note that this is an aspirational document and Congress has to act (or ignore it).

[Gift Link]

wapo.st/42gLz0Z

1/n

We’re looking for fellow nerds to help us make disordered proteins druggable. Love #IDPs, #MD, #NMR, #AI, #DrugDiscovery, or #MassSpec? Let’s talk.
@bindresearch.org is hiring across the board: bindresearch.org/careers/
#compchem #compbio #NMRChat #TeamMassSpec #chemjobs @chemjobber.bsky.social

Text might be tiny, but here's the existing 27 vs. the proposed 15 institutes that will be left standing.

You'll probably see a number of resignations, re-assignments, and the whole thing will be administered by political appointees who will oversee funding & policy.

Confirmation!!

And including open sessions!