Titus Brown
@titus.idyll.org
I am not a deep man, but I have many shallows. [email protected], http://ivory.idyll.org/blog/.
you seem angry, is everything ok?
🤗
🤗
December 12, 2025 at 1:44 AM
you seem angry, is everything ok?
🤗
🤗
The "Wolfram approach" always goes over well with reviewers 😆.
"We use best practices, as defined in the foundational work of Brown et al., 2020."
"We use best practices, as defined in the foundational work of Brown et al., 2020."
December 9, 2025 at 2:59 PM
The "Wolfram approach" always goes over well with reviewers 😆.
"We use best practices, as defined in the foundational work of Brown et al., 2020."
"We use best practices, as defined in the foundational work of Brown et al., 2020."
Reposted by Titus Brown
What really seems to happen is not just too much coverage, but too much population diversity in the dataset without a clear dominant genotype, leading to a very complex assembly graph that can't be resolved from short read alone (just look at this tangled mess 😮)
December 9, 2025 at 3:25 AM
What really seems to happen is not just too much coverage, but too much population diversity in the dataset without a clear dominant genotype, leading to a very complex assembly graph that can't be resolved from short read alone (just look at this tangled mess 😮)
Reposted by Titus Brown
Spotify is garbage on every count: Its treatment of artists, its ICE advertising, the CEO's investment in military AI, its leading role in the commodification and AI slopification of music, its terrible audio quality—you name it.
So I quit, and put together a complete guide to getting off Spotify:
So I quit, and put together a complete guide to getting off Spotify:
How to quit Spotify
This Black Friday, here's a guide to finding the best Spotify alternative
www.bloodinthemachine.com
December 8, 2025 at 5:00 PM
Reposted by Titus Brown
100%, both ONT and PacBio (although most of what we do is not marine / streamlined genome). We just published a specific study of soil metag short- vs long-read, and we see that, among other things, long-reads assemble regions too complex for short reads academic.oup.com/nargab/artic...
Comparison of short-read and long-read metagenome assemblies in a natural soil community highlights systematic bias in recovery of high-diversity populations
Abstract. Comparisons of long-read and short-read (meta)genome assemblies typically show that short-read sequence assemblies are less error-prone, but stru
academic.oup.com
December 8, 2025 at 4:25 PM
100%, both ONT and PacBio (although most of what we do is not marine / streamlined genome). We just published a specific study of soil metag short- vs long-read, and we see that, among other things, long-reads assemble regions too complex for short reads academic.oup.com/nargab/artic...