Tohru Takahashi (TmT)
@tmtakahas.bsky.social
Neuroscience for Homeostasis, Thermoregulation, Sleeping brain┊ 🐀🌡️🧠💤☀️ https://www.nature.com/articles/s41586-020-2163-6
Preoptic Neurons that Regulate Hibernation Entry
Adrian J. Martinez, Christopher M. Reid, Aurora J. Lavin-Peter, Wenhui Li, Andrew S. Lee, Eric C. Griffith, Sinisa Hrvatin
bioRxiv 2025.12.05.692394; doi: doi.org/10.64898/202...
Adrian J. Martinez, Christopher M. Reid, Aurora J. Lavin-Peter, Wenhui Li, Andrew S. Lee, Eric C. Griffith, Sinisa Hrvatin
bioRxiv 2025.12.05.692394; doi: doi.org/10.64898/202...
Preoptic Neurons that Regulate Hibernation Entry
Seasonal hibernation allows species to survive harsh environments by entering a profound hypometabolic and hypothermic state called deep torpor (DT). However, the neural mechanisms controlling entry i...
doi.org
December 16, 2025 at 4:04 PM
Preoptic Neurons that Regulate Hibernation Entry
Adrian J. Martinez, Christopher M. Reid, Aurora J. Lavin-Peter, Wenhui Li, Andrew S. Lee, Eric C. Griffith, Sinisa Hrvatin
bioRxiv 2025.12.05.692394; doi: doi.org/10.64898/202...
Adrian J. Martinez, Christopher M. Reid, Aurora J. Lavin-Peter, Wenhui Li, Andrew S. Lee, Eric C. Griffith, Sinisa Hrvatin
bioRxiv 2025.12.05.692394; doi: doi.org/10.64898/202...
The neuronal circuits and cellular encoding of thermosensation | Nature Reviews Neuroscience
www.nature.com/articles/s41...
Just amazing, ultra informative Review of Thermosensation!!!🔥❄️🌡️🧠
www.nature.com/articles/s41...
Just amazing, ultra informative Review of Thermosensation!!!🔥❄️🌡️🧠
The neuronal circuits and cellular encoding of thermosensation - Nature Reviews Neuroscience
The thermosensory system across insects and mammals has shared principles of neuronal wiring and encoding. In this Review, Carta, Vestergaard and Poulet discuss how the nervous systems of insects and ...
www.nature.com
December 6, 2025 at 1:45 AM
The neuronal circuits and cellular encoding of thermosensation | Nature Reviews Neuroscience
www.nature.com/articles/s41...
Just amazing, ultra informative Review of Thermosensation!!!🔥❄️🌡️🧠
www.nature.com/articles/s41...
Just amazing, ultra informative Review of Thermosensation!!!🔥❄️🌡️🧠
A brain–body perspective on thermoregulatory adaptation: Current Biology www.cell.com/current-biol...
A brain–body perspective on thermoregulatory adaptation
Aten et al. review how brain–body interactions modulate the thermoregulatory system
under homeostatic or adaptive conditions, including sickness, torpor and pregnancy.
www.cell.com
October 23, 2025 at 12:17 PM
A brain–body perspective on thermoregulatory adaptation: Current Biology www.cell.com/current-biol...
Neuropeptide Y neurons surrounding the locus coeruleus inhibit noradrenergic system activity to reduce anxiety | Science Advances www.science.org/doi/10.1126/...
Neuropeptide Y neurons surrounding the locus coeruleus inhibit noradrenergic system activity to reduce anxiety
Endogenous neuropeptide Y signaling modulates locus coeruleus activity, promoting adaptive responses to stress.
www.science.org
July 24, 2025 at 12:55 AM
Neuropeptide Y neurons surrounding the locus coeruleus inhibit noradrenergic system activity to reduce anxiety | Science Advances www.science.org/doi/10.1126/...
Signaling by intracellular β2-adrenergic receptors regulates AMPA receptor trafficking and synaptic plasticity: Cell Reports www.cell.com/cell-reports...
Signaling by intracellular β2-adrenergic receptors regulates AMPA receptor trafficking and synaptic plasticity
Lee et al. show that OCT3 and PMAT transport norepinephrine (NE) into neurons to stimulate
β2ARs that are in their interior. The ensuing phosphorylation of GluA1 on S845 by
PKA drives AMPARs to the su...
www.cell.com
July 22, 2025 at 2:21 PM
Signaling by intracellular β2-adrenergic receptors regulates AMPA receptor trafficking and synaptic plasticity: Cell Reports www.cell.com/cell-reports...
Single-cell spatial transcriptomic atlas of the whole mouse brain: Neuron www.cell.com/neuron/fullt...
Single-cell spatial transcriptomic atlas of the whole mouse brain
Han et al. used snRNA-seq and Stereo-seq to generate a detailed mouse brain atlas
with over 4 million spatially resolved cells and 29,655 genes. Their findings include
region- enriched cell clusters a...
www.cell.com
July 10, 2025 at 12:57 PM
Single-cell spatial transcriptomic atlas of the whole mouse brain: Neuron www.cell.com/neuron/fullt...
Channel synapse mediates neurotransmission of airway protective chemoreflexes: Cell www.cell.com/cell/fulltex...
Channel synapse mediates neurotransmission of airway protective chemoreflexes
Soma et al. identify pathways for airway protective reflexes of swallowing and respiratory
expulsion in mice, driven by rare subsets of chemosensory epithelial cells in the
hypopharynx and larynx, wit...
www.cell.com
May 18, 2025 at 11:37 AM
Channel synapse mediates neurotransmission of airway protective chemoreflexes: Cell www.cell.com/cell/fulltex...
Reposted by Tohru Takahashi (TmT)
A forthcoming policy from the US National Institutes of Health (NIH) will target — and at least temporarily stop — funding to laboratories and hospitals outside the United States.
https://go.nature.com/4cXQpnA
https://go.nature.com/4cXQpnA
Exclusive: NIH to suspend funds for research abroad as it overhauls policy
Move by US biomedical agency threatens thousands of projects on infectious diseases, cancer and more.
go.nature.com
April 30, 2025 at 11:32 PM
A forthcoming policy from the US National Institutes of Health (NIH) will target — and at least temporarily stop — funding to laboratories and hospitals outside the United States.
https://go.nature.com/4cXQpnA
https://go.nature.com/4cXQpnA
Reposted by Tohru Takahashi (TmT)
Compared to floor-only tests, the chamber assay better detects subtle warm temp differences. Mice prefer temps nearer their thermoneutral zone (~31°C). Pink = chamber; black = classic plate assay.
April 20, 2025 at 2:05 PM
Compared to floor-only tests, the chamber assay better detects subtle warm temp differences. Mice prefer temps nearer their thermoneutral zone (~31°C). Pink = chamber; black = classic plate assay.
Reposted by Tohru Takahashi (TmT)
Ambient temperature is a whole-body experience —but most tests only use heated floors, mainly probing paw/snout sensitivity. These setups might also alter room temp unpredictably, which is rarely measured/reported.
April 20, 2025 at 2:05 PM
Ambient temperature is a whole-body experience —but most tests only use heated floors, mainly probing paw/snout sensitivity. These setups might also alter room temp unpredictably, which is rarely measured/reported.
Reposted by Tohru Takahashi (TmT)
How do mice decide which ambient temperature they prefer? Our new eLife paper by Muad (@hummuscience.bsky.social) explores how TRPV1 and TRPM2 channels shape temperature preference. A quick breakdown 👇
🔗 pubmed.ncbi.nlm.nih.gov/40215103/
🔗 pubmed.ncbi.nlm.nih.gov/40215103/
Diverging roles of TRPV1 and TRPM2 in warm-temperature detection - PubMed
The perception of innocuous temperatures is crucial for thermoregulation. The TRP ion channels TRPV1 and TRPM2 have been implicated in warmth detection, yet their precise roles remain unclear. A key c...
pubmed.ncbi.nlm.nih.gov
April 20, 2025 at 2:05 PM
How do mice decide which ambient temperature they prefer? Our new eLife paper by Muad (@hummuscience.bsky.social) explores how TRPV1 and TRPM2 channels shape temperature preference. A quick breakdown 👇
🔗 pubmed.ncbi.nlm.nih.gov/40215103/
🔗 pubmed.ncbi.nlm.nih.gov/40215103/
Reposted by Tohru Takahashi (TmT)
Calorie restriction extends lifespan in many animal models, but the effects in humans and the mechanisms of action are not clear. A Review in Nature Reviews Endocrinology summarizes evidence regarding potential adverse effects of calorie restriction. go.nature.com/42XV1Xa 🔒
April 23, 2025 at 4:36 PM
Calorie restriction extends lifespan in many animal models, but the effects in humans and the mechanisms of action are not clear. A Review in Nature Reviews Endocrinology summarizes evidence regarding potential adverse effects of calorie restriction. go.nature.com/42XV1Xa 🔒
Reposted by Tohru Takahashi (TmT)
We all know how powerful memories can feel, but new work published in @nature.com shows that the memory of being exposed to cold conditions in a specific environment can alter a mouse's whole-body metabolism 🧪 www.nature.com/articles/s41...
Cold memories control whole-body thermoregulatory responses - Nature
Cold-sensitive engrams contribute to learned thermoregulation in mice that are returned to an environment in which they previously experienced a cold challenge, through a network formed betw...
www.nature.com
April 25, 2025 at 3:04 AM
We all know how powerful memories can feel, but new work published in @nature.com shows that the memory of being exposed to cold conditions in a specific environment can alter a mouse's whole-body metabolism 🧪 www.nature.com/articles/s41...
Prolactin modulation of thermoregulatory circuits provides resilience to thermal challenge of pregnancy: Cell Reports www.cell.com/cell-reports...
Prolactin modulation of thermoregulatory circuits provides resilience to thermal challenge of pregnancy
Pregnancy significantly challenges thermal homeostasis. Ladyman et al. show that a
warm-responding neuronal population in the preoptic area expresses prolactin receptors.
Deletion of prolactin recepto...
www.cell.com
April 14, 2025 at 2:44 AM
Prolactin modulation of thermoregulatory circuits provides resilience to thermal challenge of pregnancy: Cell Reports www.cell.com/cell-reports...
Fantastic Perspective…must read!
🥵🥶In a perspective, Bruno Conti and Rafael de Cabo discuss the mechanisms by which lowered body temperature prolongs lifespan and contributes to the effects of calorie restriction - online now! nature.com/articles/s43... rdcu.be/eg1Ur
Promoting health and survival through lowered body temperature - Nature Aging
Growing evidence indicates that lowered body temperature prolongs lifespan and contributes to the effects of calorie restriction across species. Conti and de Cabo discuss the mechanisms mediating thes...
nature.com
April 11, 2025 at 1:40 AM
Fantastic Perspective…must read!
Reposted by Tohru Takahashi (TmT)
Very interesting study by Lin Yuan & Co in the Julius lab, explaining how sensory neurons can adapt to exitotoxicity and calcium challenges e.g. by Trpv1 activation. Spoiler alert: the electron transport chain is involved - we enjoyed discussing it in Journal club.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Metabolic tuning facilitates nociceptor resilience to excitotoxicity
The capsaicin receptor, TRPV1, mediates the detection of harmful chemical and thermal stimuli. Overactivation of TRPV1 can lead to cellular damage or death through excitotoxicity, a phenomenon associa...
www.biorxiv.org
March 12, 2025 at 7:49 PM
Very interesting study by Lin Yuan & Co in the Julius lab, explaining how sensory neurons can adapt to exitotoxicity and calcium challenges e.g. by Trpv1 activation. Spoiler alert: the electron transport chain is involved - we enjoyed discussing it in Journal club.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Tohru Takahashi (TmT)
🥵🥶In a perspective, Bruno Conti and Rafael de Cabo discuss the mechanisms by which lowered body temperature prolongs lifespan and contributes to the effects of calorie restriction - online now! nature.com/articles/s43... rdcu.be/eg1Ur
Promoting health and survival through lowered body temperature - Nature Aging
Growing evidence indicates that lowered body temperature prolongs lifespan and contributes to the effects of calorie restriction across species. Conti and de Cabo discuss the mechanisms mediating thes...
nature.com
April 9, 2025 at 10:53 AM
🥵🥶In a perspective, Bruno Conti and Rafael de Cabo discuss the mechanisms by which lowered body temperature prolongs lifespan and contributes to the effects of calorie restriction - online now! nature.com/articles/s43... rdcu.be/eg1Ur
Scientists uncover how the brain washes itself during sleep | Science | AAAS www.science.org/content/arti...
Scientists uncover how the brain washes itself during sleep
Pulsating blood vessels push fluid into and out of the brains of slumbering mice
www.science.org
February 7, 2025 at 3:27 PM
Scientists uncover how the brain washes itself during sleep | Science | AAAS www.science.org/content/arti...
Identification of the subventricular tegmental nucleus as brainstem reward center | Science www.science.org/doi/10.1126/...
Identification of the subventricular tegmental nucleus as brainstem reward center
Rewards are essential for motivation, decision-making, memory, and mental health. We identified the subventricular tegmental nucleus (SVTg) as a brainstem reward center. In mice, reward and its predic...
www.science.org
January 28, 2025 at 11:43 AM
Identification of the subventricular tegmental nucleus as brainstem reward center | Science www.science.org/doi/10.1126/...
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring | Science | AAAS www.science.org/content/arti...
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
www.science.org
January 23, 2025 at 12:44 PM
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring | Science | AAAS www.science.org/content/arti...
Reposted by Tohru Takahashi (TmT)
My Dispatch on the thermoregulatory inversion article:
"Speculatively, hypothermia circuits may be employed naturally to rescue an endotherm animal in extremely dire situations. This could even exist in humans: ...
authors.elsevier.com/a/1kOXg3QW8S...
"Speculatively, hypothermia circuits may be employed naturally to rescue an endotherm animal in extremely dire situations. This could even exist in humans: ...
authors.elsevier.com/a/1kOXg3QW8S...
January 6, 2025 at 8:30 PM
My Dispatch on the thermoregulatory inversion article:
"Speculatively, hypothermia circuits may be employed naturally to rescue an endotherm animal in extremely dire situations. This could even exist in humans: ...
authors.elsevier.com/a/1kOXg3QW8S...
"Speculatively, hypothermia circuits may be employed naturally to rescue an endotherm animal in extremely dire situations. This could even exist in humans: ...
authors.elsevier.com/a/1kOXg3QW8S...
Reposted by Tohru Takahashi (TmT)
Congratulations to Domenico Tupone and lab and collaborators for more fascinating work identifying neural circuits that reverse thermoregulation, involving the preoptic area, parabrachial nucleus and dynorphin! Torpor in non-torpid species!
🧠🌡
www.sciencedirect.com/science/arti...
🧠🌡
www.sciencedirect.com/science/arti...
Inhibition of the hypothalamic ventromedial periventricular area activates a dynorphin pathway-dependent thermoregulatory inversion in rats
To maintain core body temperature in mammals, CNS thermoregulatory networks respond to cold exposure by increasing brown adipose tissue and shivering …
www.sciencedirect.com
January 6, 2025 at 8:26 PM
Congratulations to Domenico Tupone and lab and collaborators for more fascinating work identifying neural circuits that reverse thermoregulation, involving the preoptic area, parabrachial nucleus and dynorphin! Torpor in non-torpid species!
🧠🌡
www.sciencedirect.com/science/arti...
🧠🌡
www.sciencedirect.com/science/arti...
A discrete neuronal circuit induces a hibernation-like state in rodents @digital-science.com
🦋
app.dimensions.ai/details/publ...
🦋
app.dimensions.ai/details/publ...
A discrete neuronal circuit induces a hibernation-like state in rodents - Dimensions
Hibernating mammals actively lower their body temperature to reduce energy expenditure when facing food scarcity1. This ability to induce a hypometabolic state has evoked great interest owing to its p...
app.dimensions.ai
January 1, 2025 at 10:51 PM
A discrete neuronal circuit induces a hibernation-like state in rodents @digital-science.com
🦋
app.dimensions.ai/details/publ...
🦋
app.dimensions.ai/details/publ...