tobiasgreisle.bsky.social
Tobias Greisle
@tobiasgreisle.bsky.social
82 followers 100 following 2 posts
PhD student in the Lickert lab at Helmholtz Center Munich. Excited about stem cells, pancreas development and cilia.
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tobiasgreisle.bsky.social
Tobias Greisle @tobiasgreisle.bsky.social · 11d
Thanks, I hope it's helpful!
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tobiasgreisle.bsky.social
Tobias Greisle @tobiasgreisle.bsky.social · 12d
Happy to share a new tool from the @heikolickert.bsky.social lab!
We generated human iPSC fluorescent reporter lines to monitor Wnt/PCP signaling activity by Flattop in stem cell derived β-cells.
doi.org/10.1016/j.sc...
Thanks to all the co-authors that helped in the present and the past!
Redirecting
doi.org
2
Reposted by Tobias Greisle
ckarampelias.bsky.social
Christos Karampelias @ckarampelias.bsky.social · Mar 14
Happy to share our work on pancreatic ductal organoids from the human-relevant pig model across developmental stages ranging from embryonic to adult animals and using them for drug screening applications from the @heikolickert.bsky.social lab. #PancSky #devbio 🧪🧬 www.biorxiv.org/content/10.1... /1
Benchmarking porcine pancreatic ductal organoids for drug screening applications
Primary human pancreatic ductal organoids (HPDO) have emerged as a model to study pancreas biology and disease. Yet, donor material availability, and a lack of extensive benchmarking limits the range ...
www.biorxiv.org
1 9 18
Reposted by Tobias Greisle
heikolickert.bsky.social
Heiko Lickert @heikolickert.bsky.social · Dec 19
My top highlight for 2025 - EMBO workshop in Saint Feliu - three exciting days of science crossing boundaries of liver & pancreas research! Co-organised by @CebolaLab @1jorgeferrer @VallierLab @LickertHeiko & Emma Anderson #livertwitter #islets #masld #diabetes

meetings.embo.org/event/25-liv...
Liver and pancreas in metabolic disease: from pathways to therapies
The liver and pancreas arise from a common developmental origin and are controlled by shared gene regulatory programs.These organs are central to two of the most common and devastating metabolic dise…
meetings.embo.org
9 15
Reposted by Tobias Greisle
jorge-ferrer.bsky.social
Jorge Ferrer @jorge-ferrer.bsky.social · Dec 21
Join us in a beautiful location for this multidisciplinary experience. Top speakers linking topics such as organoid modeling, synthetic biology, gene regulation or genetics with disease mechanisms & new therapies for T1D, T2D, and MASLD

meetings.embo.org/event/25-liver-pancreas
Liver and pancreas in metabolic disease: from pathways to therapies
The liver and pancreas arise from a common developmental origin and are controlled by shared gene regulatory programs.These organs are central to two of the most common and devastating metabolic dise…
meetings.embo.org
2 12 17
Reposted by Tobias Greisle
heikolickert.bsky.social
Heiko Lickert @heikolickert.bsky.social · Nov 25
Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
Inceptor binds to and directs insulin towards lysosomal degradation in β cells - Nature Metabolism
The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.
doi.org
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