Tom Jové
@tomjove.bsky.social
Docteur en microbiologie/biologie moléculaire. Père.
Biologie, musique, sciences et SF. Integrons Nerd.
https://tinyurl.com/Bacteriomatics
Biologie, musique, sciences et SF. Integrons Nerd.
https://tinyurl.com/Bacteriomatics
Pinned
🚨 First 2026 monthly update (namely V19) of the freely available mobile #integrons analysis (n= 2097), available here: tinyurl.com/Integrons-An...
Direct download : tinyurl.com/Integrons-An...
#antibioticresistance
Direct download : tinyurl.com/Integrons-An...
#antibioticresistance
🚨 First 2026 monthly update (namely V19) of the freely available mobile #integrons analysis (n= 2097), available here: tinyurl.com/Integrons-An...
Direct download : tinyurl.com/Integrons-An...
#antibioticresistance
Direct download : tinyurl.com/Integrons-An...
#antibioticresistance
January 18, 2026 at 12:52 AM
🚨 First 2026 monthly update (namely V19) of the freely available mobile #integrons analysis (n= 2097), available here: tinyurl.com/Integrons-An...
Direct download : tinyurl.com/Integrons-An...
#antibioticresistance
Direct download : tinyurl.com/Integrons-An...
#antibioticresistance
Last 2025 monthly update (namely V18) of the freely available mobile integrons analysis (n= 2027), available here: tinyurl.com/Integrons-An.... Direct download : tinyurl.com/Integrons-An...
December 20, 2025 at 11:48 PM
Last 2025 monthly update (namely V18) of the freely available mobile integrons analysis (n= 2027), available here: tinyurl.com/Integrons-An.... Direct download : tinyurl.com/Integrons-An...
Novel monthly update (namely V17) of the freely available mobile integrons analysis (n=1949) , available here: tinyurl.com/Integrons-An... Direct download here: tinyurl.com/Integrons-An... #antibioticresistance
November 22, 2025 at 11:43 PM
Novel monthly update (namely V17) of the freely available mobile integrons analysis (n=1949) , available here: tinyurl.com/Integrons-An... Direct download here: tinyurl.com/Integrons-An... #antibioticresistance
Novel monthly update (namely V16) of the freely available mobile integrons analysis (n=1777) , available here: tinyurl.com/Integrons-An... Direct download here: tinyurl.com/Integrons-An... #antibioticresistance
October 19, 2025 at 4:14 PM
Novel monthly update (namely V16) of the freely available mobile integrons analysis (n=1777) , available here: tinyurl.com/Integrons-An... Direct download here: tinyurl.com/Integrons-An... #antibioticresistance
Novel monthly update (namely V15) of the freely available mobile integrons analysis (n=1725) , available here: tinyurl.com/Integrons-An... Direct download here: tinyurl.com/Integrons-Analysis-V15
September 21, 2025 at 10:34 PM
Novel monthly update (namely V15) of the freely available mobile integrons analysis (n=1725) , available here: tinyurl.com/Integrons-An... Direct download here: tinyurl.com/Integrons-Analysis-V15
Beyond plasmid addiction: the role of toxin–antitoxin systems in the selfish behavior of mobile genetic elements | Journal of Bacteriology journals.asm.org/doi/full/10....
Beyond plasmid addiction: the role of toxin–antitoxin systems in the selfish behavior of mobile genetic elements | Journal of Bacteriology
The term plasmid addiction was originally coined to describe the role of TA systems in ensuring plasmid maintenance
within bacterial populations (1). These systems promote plasmid stability through a ...
journals.asm.org
September 20, 2025 at 8:44 PM
Beyond plasmid addiction: the role of toxin–antitoxin systems in the selfish behavior of mobile genetic elements | Journal of Bacteriology journals.asm.org/doi/full/10....
E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism | Science www.science.org/doi/abs/10.1...
E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism
Transcription factors (TFs) may activate or repress gene expression through an interplay of different mechanisms, including RNA polymerase (RNAP) recruitment, exclusion, and initiation. However, depen...
www.science.org
September 15, 2025 at 11:46 PM
E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism | Science www.science.org/doi/abs/10.1...
Monthly update (namely V14) of the freely available mobile integrons analysis (n=1623) , available here: tinyurl.com/Integrons-An... Direct download here: tinyurl.com/integrons-an...
August 23, 2025 at 11:03 PM
Monthly update (namely V14) of the freely available mobile integrons analysis (n=1623) , available here: tinyurl.com/Integrons-An... Direct download here: tinyurl.com/integrons-an...
SAND: a comprehensive annotation of class D β-lactamases using structural alignment-based numbering | Antimicrobial Agents and Chemotherapy journals.asm.org/doi/10.1128/...
SAND: a comprehensive annotation of class D β-lactamases using structural alignment-based numbering | Antimicrobial Agents and Chemotherapy
Class D β-lactamases (DBLs) form a large family with nearly 1,300 identified members
in the β-Lactamase Database (Fig. S1, www.bldb.euhttp://www.bldb.eu/) (1). They are produced mainly by Gram-negativ...
journals.asm.org
July 25, 2025 at 10:02 PM
SAND: a comprehensive annotation of class D β-lactamases using structural alignment-based numbering | Antimicrobial Agents and Chemotherapy journals.asm.org/doi/10.1128/...
DNA replication initiation timing is important for maintaining genome integrity | Journal of Bacteriology journals.asm.org/doi/full/10....
DNA replication initiation timing is important for maintaining genome integrity | Journal of Bacteriology
The regulation of DNA replication is fundamental to cell growth and cell cycle control.
In eukaryotes, under-initiation or over-initiation leads to genome instability. In
bacteria, it is unclear how c...
journals.asm.org
July 22, 2025 at 10:13 PM
DNA replication initiation timing is important for maintaining genome integrity | Journal of Bacteriology journals.asm.org/doi/full/10....
Novel monthly update (namely V13) of the freely available mobile integrons analysis (n=1508) , available here: tinyurl.com/Integrons-An... Direct download here: tinyurl.com/integrons-an....
I started to work on class 2 integrons too.
I started to work on class 2 integrons too.
July 20, 2025 at 11:32 PM
Novel monthly update (namely V13) of the freely available mobile integrons analysis (n=1508) , available here: tinyurl.com/Integrons-An... Direct download here: tinyurl.com/integrons-an....
I started to work on class 2 integrons too.
I started to work on class 2 integrons too.
catA1 chloramphenicol resistance gene originated in Atlantibacter hermannii url: academic.oup.com/jac/article/...
The catA1 chloramphenicol resistance gene originated in Atlantibacter hermannii
The origins of several of the antibiotic resistance genes that commonly circulate in bacterial pathogens have been revealed over the last two decades due t
academic.oup.com
July 11, 2025 at 10:20 PM
catA1 chloramphenicol resistance gene originated in Atlantibacter hermannii url: academic.oup.com/jac/article/...
Novel monthly update (namely V12) of the freely available mobile integrons analysis (n=1310) , available here: tinyurl.com/Integrons-An....
Direct download here:
tinyurl.com/integrons-an...
Direct download here:
tinyurl.com/integrons-an...
June 21, 2025 at 5:32 PM
Novel monthly update (namely V12) of the freely available mobile integrons analysis (n=1310) , available here: tinyurl.com/Integrons-An....
Direct download here:
tinyurl.com/integrons-an...
Direct download here:
tinyurl.com/integrons-an...
A fascinating novel bacterial antiphage defense system
www.science.org/doi/abs/10.1...
www.science.org/doi/abs/10.1...
Bacterial reverse transcriptase synthesizes long poly(A)-rich cDNA for antiphage defense
Prokaryotic defense-associated reverse transcriptases (DRTs) were recently identified with antiviral functions; however, their functional mechanisms remain largely unexplored. Here we show that DRT9 f...
www.science.org
June 19, 2025 at 9:23 PM
A fascinating novel bacterial antiphage defense system
www.science.org/doi/abs/10.1...
www.science.org/doi/abs/10.1...
Second monthly update (namely V11) of the freely available mobile integrons analysis, available here: tinyurl.com/Integrons-An...
Direct download here: tinyurl.com/integrons-an...
Direct download here: tinyurl.com/integrons-an...
May 29, 2025 at 11:38 PM
Second monthly update (namely V11) of the freely available mobile integrons analysis, available here: tinyurl.com/Integrons-An...
Direct download here: tinyurl.com/integrons-an...
Direct download here: tinyurl.com/integrons-an...
Reposted by Tom Jové
Interested in phages ?
Want to work as team that will isolate, genome sequence and charachterise 1000s of phage to build a biobank .
Come work with me and Martha Clokie at Leicester
jobs.le.ac.uk/vacancies/va...
Want to work as team that will isolate, genome sequence and charachterise 1000s of phage to build a biobank .
Come work with me and Martha Clokie at Leicester
jobs.le.ac.uk/vacancies/va...
Vacancy Search Results - University of Leicester Recruitment Team
View our Latest Vacancies
jobs.le.ac.uk
May 16, 2025 at 11:40 AM
Interested in phages ?
Want to work as team that will isolate, genome sequence and charachterise 1000s of phage to build a biobank .
Come work with me and Martha Clokie at Leicester
jobs.le.ac.uk/vacancies/va...
Want to work as team that will isolate, genome sequence and charachterise 1000s of phage to build a biobank .
Come work with me and Martha Clokie at Leicester
jobs.le.ac.uk/vacancies/va...
Reposted by Tom Jové
Habemus paper! Our story on integron-encoded anti-phage defenses is now out in @science.org! 16 new systems, small versions of known ones, and a lot more in this highly-collaborative study.
Many thanks to everyone involved, especially my supervisor @epcrocha.bsky.social
bsky.app/profile/bapt...
Many thanks to everyone involved, especially my supervisor @epcrocha.bsky.social
bsky.app/profile/bapt...
White smoke, we have a new pope and also 16 new anti-phages systems in sedentary integrons (SCIs) !
In collaboration with the Rocha lab, we show in our new paper that cassettes of these large platforms encode many known anti-phage defenses, and uncovered 16 new ones.
www.science.org/doi/10.1126/...
In collaboration with the Rocha lab, we show in our new paper that cassettes of these large platforms encode many known anti-phage defenses, and uncovered 16 new ones.
www.science.org/doi/10.1126/...
Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems
Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...
www.science.org
May 9, 2025 at 11:51 AM
Habemus paper! Our story on integron-encoded anti-phage defenses is now out in @science.org! 16 new systems, small versions of known ones, and a lot more in this highly-collaborative study.
Many thanks to everyone involved, especially my supervisor @epcrocha.bsky.social
bsky.app/profile/bapt...
Many thanks to everyone involved, especially my supervisor @epcrocha.bsky.social
bsky.app/profile/bapt...
Reposted by Tom Jové
Our paper is published back2back with one from @amazeld.bsky.social and @epcrocha.bsky.social labs where @baptistedarracq.bsky.social, @eloilittner.bsky.social and co. show that Sedentary Chromosomal Integrons are biobanks of phage defense systems. www.science.org/doi/10.1126/...
Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems
Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...
www.science.org
May 8, 2025 at 8:27 PM
Our paper is published back2back with one from @amazeld.bsky.social and @epcrocha.bsky.social labs where @baptistedarracq.bsky.social, @eloilittner.bsky.social and co. show that Sedentary Chromosomal Integrons are biobanks of phage defense systems. www.science.org/doi/10.1126/...
Happy and proud to have contributed to this great work now published in @aaas.org @science.org . A milestone in the understanding of integrons biology. Congratulations to your team @jaescudero.bsky.social
🧪
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
Mobile integrons encode phage defense systems
Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...
www.science.org
May 8, 2025 at 9:00 PM
Happy and proud to have contributed to this great work now published in @aaas.org @science.org . A milestone in the understanding of integrons biology. Congratulations to your team @jaescudero.bsky.social
Reposted by Tom Jové
Can resistance genes really hold their breath like pros? 🤔🤿
Outstanding work by Laura, Amalia, Nico and Ester from @jaescudero.bsky.social lab in collab with @sanmillan.bsky.social, Fernando Baquero and Rafael Cantón.
Dive into our latest paper to find out! 👇🏼
www.sciencedirect.com/science/arti...
Outstanding work by Laura, Amalia, Nico and Ester from @jaescudero.bsky.social lab in collab with @sanmillan.bsky.social, Fernando Baquero and Rafael Cantón.
Dive into our latest paper to find out! 👇🏼
www.sciencedirect.com/science/arti...
Effect of oxygen on antimicrobial resistance genes from a one health perspective
Bacteria must face and adapt to a variety of physicochemical conditions in the environment and during infection. A key condition is the concentration …
www.sciencedirect.com
April 30, 2025 at 10:59 AM
Can resistance genes really hold their breath like pros? 🤔🤿
Outstanding work by Laura, Amalia, Nico and Ester from @jaescudero.bsky.social lab in collab with @sanmillan.bsky.social, Fernando Baquero and Rafael Cantón.
Dive into our latest paper to find out! 👇🏼
www.sciencedirect.com/science/arti...
Outstanding work by Laura, Amalia, Nico and Ester from @jaescudero.bsky.social lab in collab with @sanmillan.bsky.social, Fernando Baquero and Rafael Cantón.
Dive into our latest paper to find out! 👇🏼
www.sciencedirect.com/science/arti...
First monthly update (namely V10) of the freely available mobile integrons analysis here: tinyurl.com/Integrons-An... . Direct download here: tinyurl.com/integrons-an...
April 20, 2025 at 5:58 PM
First monthly update (namely V10) of the freely available mobile integrons analysis here: tinyurl.com/Integrons-An... . Direct download here: tinyurl.com/integrons-an...
Class 1 Integrons as Valuable Targets for the
Re-sensitization of MDR bacteria #antibioticresistance
www.biorxiv.org/content/bior...
Re-sensitization of MDR bacteria #antibioticresistance
www.biorxiv.org/content/bior...
www.biorxiv.org
April 1, 2025 at 10:32 PM
Class 1 Integrons as Valuable Targets for the
Re-sensitization of MDR bacteria #antibioticresistance
www.biorxiv.org/content/bior...
Re-sensitization of MDR bacteria #antibioticresistance
www.biorxiv.org/content/bior...
Telomeric transposons are pervasive in linear bacterial genomes | Science www.science.org/doi/abs/10.1...
Telomeric transposons are pervasive in linear bacterial genomes
Eukaryotes have linear DNA, and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. We identified several families of independently evolved telomeric tran...
www.science.org
March 27, 2025 at 9:33 PM
Telomeric transposons are pervasive in linear bacterial genomes | Science www.science.org/doi/abs/10.1...