Tom Scriba
@tomscriba.bsky.social
Professor in Immunology at University of Cape Town, Deputy Director at South African Tuberculosis Vaccine Initiative.
Views are my own.
Views are my own.
Reposted by Tom Scriba
Summary of this report in case access is a problem
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 4, 2026 at 5:26 PM
Summary of this report in case access is a problem
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Tom Scriba
Remarkably, this phosphate-limitation response does not kill the bacterium, suggesting it is reversible and functionally equivalent. Electron microscopy by Max Gutierrez @maxgg.bsky.social and colleagues shows a structured and ~10% thicker cell envelope associated with this remodeling.
December 22, 2025 at 1:13 PM
Remarkably, this phosphate-limitation response does not kill the bacterium, suggesting it is reversible and functionally equivalent. Electron microscopy by Max Gutierrez @maxgg.bsky.social and colleagues shows a structured and ~10% thicker cell envelope associated with this remodeling.
Reposted by Tom Scriba
These findings highlight that decades of research have focused on an artificial lipid profile, shaped by the high phosphate content of Middlebrook media and likely modestly relevant for infection. The data also reveals a high degree of plasticity in the composition of Mtb cell envelope.
December 22, 2025 at 1:13 PM
These findings highlight that decades of research have focused on an artificial lipid profile, shaped by the high phosphate content of Middlebrook media and likely modestly relevant for infection. The data also reveals a high degree of plasticity in the composition of Mtb cell envelope.