A study of 483 mammoth remains spanning over a million years reveals ancient host-associated microbes preserved in bones and teeth, offering new insights into the long-term evolution of Pleistocene microbiomes and their association with megafaunal hosts.

Elas estão a ler mais do que eles, principalmente romances, fantasia e thrillers. Homens escolhem a não-ficção em nome do autoaperfeiçoamento e evitam ler autoras mulheres. Mas há quem contrarie.

Researchers are alarmed that the move might upend a long-standing tradition of peer-review for grants.

PARIS—In an effort to modernize the principles and empirical procedures of examining phenomena and advancing humanity’s collective knowledge, the International Council for Science announced Thursday t...

The month’s sharpest science shots, selected by Nature’s photo team.

Joana Gonçalves-Sá, from LIP’s SPAC group, receives ERC Proof of Concept grant to audit recommendations from search engines and LLMs.

Discover Postdoctoral Research Associate jobs and more in higher education on jobs.ac.uk. Apply for further details on the top job board.

Biobanco do Instituto Gulbenkian de Medicina Molecular foi escolhido pela Agência Espacial Europeia para acolher as amostras biológicas dos astronautas europeus. Seis mil amostras chegam já este ano.

The proposal for the next Horizon Europe is in, with funding increases all round, including a tripling of the budget for the EU’s innovation scheme, the European Innovation Council (EIC).The European ...

Research has identified gender differences in orgasm frequency during sex between heterosexual individuals. This orgasm gap is reduced for cisgender women who have sex with women, while cisgender m...

More than 2,700 human mRNA 3′UTRs have hundreds of highly conserved (HC) nucleotides, but their biological roles are unclear. Here, we show that mRNAs with HC 3′UTRs mostly encode proteins with long intrinsically disordered regions (IDRs), including MYC, UTX, and JMJD3. These proteins are only fully active when translated from mRNA templates that include their 3′UTRs, raising the possibility of functional interactions between 3′UTRs and IDRs. Rather than affecting protein abundance or localization, we find that HC 3′UTRs control transcriptional or histone demethylase activity through co-translationally determined protein oligomerization states that are kinetically stable. 3′UTR-dependent changes in protein folding require mRNA-IDR interactions, suggesting that mRNAs act as IDR chaperones. These mRNAs are multivalent, a biophysical RNA feature that enables their translation in network-like condensates, which provide favorable folding environments for proteins with long IDRs. These data indicate that the coding sequence is insufficient for the biogenesis of biologically active conformations of IDR-containing proteins and that RNA can catalyze protein folding. ### Competing Interest Statement The authors have declared no competing interest. Pershing Square Foundation, https://ror.org/04tce9s05 G. Harold & Leila Y. Mathers Foundation National Institutes of Health, DP1GM123454, R35GM144046 Memorial Sloan Kettering Cancer Center, https://ror.org/02yrq0923, P30 CA008748

Todos os dias são gerados milhões de dados nos mais diversos domínios científicos, mas pouco se discute sobre o que realmente fazemos com essa informação.