Tongyu (Tony) Liu
@tonyl1415.bsky.social
Ph.D. in Microbiology, studying influenza virus. A photographer among virologists. Beijing-> IL -> MD
Reposted by Tongyu (Tony) Liu
First big piece of research from our SG lab: Fadi's work with Chris Brooke's lab. Flu serially passaged 80X selects a defective genome with improved competition, but is nonviable as a full virus!
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Longitudinal analysis of influenza A virus deletion-containing viral genomes reveals key determinants of co-evolutionary dynamics and interference
The substantial genetic diversity generated during influenza A virus replication facilitates both evasion of pre-existing host immunity and cross-species emergence. A major contributor to this diversi...
www.biorxiv.org
November 4, 2025 at 3:17 AM
First big piece of research from our SG lab: Fadi's work with Chris Brooke's lab. Flu serially passaged 80X selects a defective genome with improved competition, but is nonviable as a full virus!
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Reposted by Tongyu (Tony) Liu
@joelrc.bsky.social 's paper on differences between the seasonal H1N1 and H3N2 lineages in their relative capacity to antagonize IFN induction and signaling at the single cell level is out now in PLOS Pathogens:
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Seasonal influenza a virus lineages exhibit divergent abilities to antagonize interferon induction and signaling
Author summary Successful replication and transmission of influenza A viruses (IAVs) requires effective subversion of the innate immune response. We developed a new single cell method to examine the i...
journals.plos.org
December 12, 2024 at 6:58 PM
@joelrc.bsky.social 's paper on differences between the seasonal H1N1 and H3N2 lineages in their relative capacity to antagonize IFN induction and signaling at the single cell level is out now in PLOS Pathogens:
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Reposted by Tongyu (Tony) Liu
Check out @tonyl1415.bsky.social 's new paper on how the evolutionary potential of the seasonal H1N1 HA gene is influenced by its interactions with neuraminidase!
academic.oup.com/ve/article/1...
academic.oup.com/ve/article/1...
Natural variation in neuraminidase activity influences the evolutionary potential of the seasonal H1N1 lineage hemagglutinin
Abstract. The antigenic evolution of the influenza A virus hemagglutinin (HA) gene poses a major challenge for the development of vaccines capable of elici
academic.oup.com
June 25, 2024 at 6:59 PM
Check out @tonyl1415.bsky.social 's new paper on how the evolutionary potential of the seasonal H1N1 HA gene is influenced by its interactions with neuraminidase!
academic.oup.com/ve/article/1...
academic.oup.com/ve/article/1...