Vignuzzi Lab
@vignuzzilab.bsky.social
Antiviral therapeutics and virology. ASTAR ID Labs in Singapore.
The future of vaccines is the future of vaccines itself!
Listen to Apriori Bio CEO Craig Williams lay out how new vaccines will improve public health and better outbreak response.
Our group is partnering with them in a match made in 🤩 science heaven 🤩.
youtu.be/iskugkfU2hc
Listen to Apriori Bio CEO Craig Williams lay out how new vaccines will improve public health and better outbreak response.
Our group is partnering with them in a match made in 🤩 science heaven 🤩.
youtu.be/iskugkfU2hc
2026 CEO Chat: Craig Williams, CEO of Apriori Bio
YouTube video by Flagship Pioneering
youtu.be
January 22, 2026 at 11:53 PM
The future of vaccines is the future of vaccines itself!
Listen to Apriori Bio CEO Craig Williams lay out how new vaccines will improve public health and better outbreak response.
Our group is partnering with them in a match made in 🤩 science heaven 🤩.
youtu.be/iskugkfU2hc
Listen to Apriori Bio CEO Craig Williams lay out how new vaccines will improve public health and better outbreak response.
Our group is partnering with them in a match made in 🤩 science heaven 🤩.
youtu.be/iskugkfU2hc
Today, Fish Hui Xian Poh presented this work by groups at the Chinese Academy of Sciences in Beijing. They dissected alpha virus SFV into nsPs, Capsid, Envelope to make VLPs for RNA or protein delivery - in some cases to target the blood-brain barrier. Very cool work!
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Engineering a streamlined virus-like particle for programmable tissue-specific gene delivery - Nature Communications
Virus-like particles (VLPs) offer powerful gene delivery but face limits in targeting and complexity. Here, the authors create a streamlined SFV-based VLP platform that delivers mRNA, protein, or RNP ...
doi.org
January 21, 2026 at 10:30 AM
Today, Fish Hui Xian Poh presented this work by groups at the Chinese Academy of Sciences in Beijing. They dissected alpha virus SFV into nsPs, Capsid, Envelope to make VLPs for RNA or protein delivery - in some cases to target the blood-brain barrier. Very cool work!
doi.org/10.1038/s414...
doi.org/10.1038/s414...
A wonderful visit from Peggy, our lab’s retired admin assistant. She brought me my own name stamp in Chinese characters handmade in Shanghai ! ❤️
January 20, 2026 at 4:56 AM
A wonderful visit from Peggy, our lab’s retired admin assistant. She brought me my own name stamp in Chinese characters handmade in Shanghai ! ❤️
Reposted by Vignuzzi Lab
Viral theft of light: A cyanophage protein dismantles cyanobacterial photosynthesis to accelerate infection www.cell.com/cell-host-mi...
Viral theft of light: A cyanophage protein dismantles cyanobacterial photosynthesis to accelerate infection
Auxiliary metabolic genes, acquired by cyanobacterial viruses (cyanophages) from their
hosts, are thought to manipulate host metabolism during infection. A recent study
by Nadel et al. performed in vi...
www.cell.com
January 17, 2026 at 7:25 PM
Viral theft of light: A cyanophage protein dismantles cyanobacterial photosynthesis to accelerate infection www.cell.com/cell-host-mi...
Happy birthday to Judy and Dinh! Celebrating with Galette des rois and Kouign amann during lab meeting.
January 17, 2026 at 1:54 AM
Happy birthday to Judy and Dinh! Celebrating with Galette des rois and Kouign amann during lab meeting.
Reposted by Vignuzzi Lab
A*STAR/KCL PhD scholarship available!
Dream of doing cutting-edge research, travelling between continents, and becoming obsessed with modelling infections in zebrafish?
My lab and @oehlerslab.org are looking for you!
Project details: 👉 shorturl.at/mkt1a
Catalogue page 6, project 2.1!
Dream of doing cutting-edge research, travelling between continents, and becoming obsessed with modelling infections in zebrafish?
My lab and @oehlerslab.org are looking for you!
Project details: 👉 shorturl.at/mkt1a
Catalogue page 6, project 2.1!
Joint A*STAR - King’s College London PhD Studentships in Biomedical Science 2026/27
King's College London is seeking outstanding and motivated students to join our university and the Agency for Science, Technology and Research (A*STAR).
shorturl.at
January 15, 2026 at 5:47 PM
A*STAR/KCL PhD scholarship available!
Dream of doing cutting-edge research, travelling between continents, and becoming obsessed with modelling infections in zebrafish?
My lab and @oehlerslab.org are looking for you!
Project details: 👉 shorturl.at/mkt1a
Catalogue page 6, project 2.1!
Dream of doing cutting-edge research, travelling between continents, and becoming obsessed with modelling infections in zebrafish?
My lab and @oehlerslab.org are looking for you!
Project details: 👉 shorturl.at/mkt1a
Catalogue page 6, project 2.1!
www.linkedin.com/posts/isar-i...
Voting for the international society for antiviral research board members is open! Vote for me, if you want me aboard, or vote any of the great colleagues that have added their names. Join ISAR and attend the annual conference we hold around the world.
Voting for the international society for antiviral research board members is open! Vote for me, if you want me aboard, or vote any of the great colleagues that have added their names. Join ISAR and attend the annual conference we hold around the world.
International society for antiviral research | International Society for Antiviral Research (ISAR)
Do you want to shape the future of antiviral research and development? This is your opportunity to become a member of the International Society for Antiviral Research (ISAR) and vote for the next Pres...
www.linkedin.com
January 14, 2026 at 10:43 PM
www.linkedin.com/posts/isar-i...
Voting for the international society for antiviral research board members is open! Vote for me, if you want me aboard, or vote any of the great colleagues that have added their names. Join ISAR and attend the annual conference we hold around the world.
Voting for the international society for antiviral research board members is open! Vote for me, if you want me aboard, or vote any of the great colleagues that have added their names. Join ISAR and attend the annual conference we hold around the world.
I’m happy and proud to be part of this scientist’s career. First as research assistant, seeing him through an engineer’s degree, and now passing his PhD qualifying exam!
Bravo Thomas!
Bravo Thomas!
January 13, 2026 at 10:28 AM
I’m happy and proud to be part of this scientist’s career. First as research assistant, seeing him through an engineer’s degree, and now passing his PhD qualifying exam!
Bravo Thomas!
Bravo Thomas!
www.stemcell.com/forms/organo...
One day meeting on organoids. Come see and share on who’s doing what with organoids in SG!
One day meeting on organoids. Come see and share on who’s doing what with organoids in SG!
Back for the Third Time: Organoid Day 2026!
Organoid Day returns with expert talks and the latest research in 3D cell culture. Sign up now—spaces are limited!
www.stemcell.com
January 13, 2026 at 3:46 AM
www.stemcell.com/forms/organo...
One day meeting on organoids. Come see and share on who’s doing what with organoids in SG!
One day meeting on organoids. Come see and share on who’s doing what with organoids in SG!
Check out this miniReview by Guisheng Zeng from @astar-idlabs.bsky.social and his colleagues in Nanjing, China on nanomaterial-based antimicrobials to reactivate dormant bacteria and eliminate persistent bugs.
www.frontiersin.org/journals/mic...
www.frontiersin.org/journals/mic...
Frontiers | Antibacterial nanoagents: an emerging arsenal against bacterial persisters
Bacterial persisters represent a metabolically dormant or slow-growing subpopulation within bacterial communities that exhibit resistance to antibiotics. The...
www.frontiersin.org
January 11, 2026 at 12:31 AM
Check out this miniReview by Guisheng Zeng from @astar-idlabs.bsky.social and his colleagues in Nanjing, China on nanomaterial-based antimicrobials to reactivate dormant bacteria and eliminate persistent bugs.
www.frontiersin.org/journals/mic...
www.frontiersin.org/journals/mic...
First lab meeting of 2026! And it was a great one, with beautiful results! These folks are brilliant! Bravo to Judy and Denzel for their beautiful work on alphavirus proteomics and flavivirus antivirals!
January 9, 2026 at 5:03 AM
First lab meeting of 2026! And it was a great one, with beautiful results! These folks are brilliant! Bravo to Judy and Denzel for their beautiful work on alphavirus proteomics and flavivirus antivirals!
Welcome to our lab Dylan Kwan, a coop exchange student from
Simon Fraser University in Canada!
Simon Fraser University in Canada!
January 5, 2026 at 6:50 AM
Welcome to our lab Dylan Kwan, a coop exchange student from
Simon Fraser University in Canada!
Simon Fraser University in Canada!
Reposted by Vignuzzi Lab
My first lead author paper is out with Ben Kerr and @alisonfeder.bsky.social! We found that making an antiviral too strong can sometimes make resistance easier to evolve. This has implications for how we design drugs, choose doses, and think about viral evolution in the face of treatment. (1/n)
Intracellular interactions shape antiviral resistance outcomes in poliovirus via eco-evolutionary feedback - Nature Ecology & Evolution
A model of intrahost poliovirus replication shows that, after several rounds of replication, pocapavir, a poliovirus capsid inhibitor, collapses viral density, preventing intracellular interactions th...
www.nature.com
December 8, 2025 at 5:15 PM
My first lead author paper is out with Ben Kerr and @alisonfeder.bsky.social! We found that making an antiviral too strong can sometimes make resistance easier to evolve. This has implications for how we design drugs, choose doses, and think about viral evolution in the face of treatment. (1/n)
Congratulations to Wei Hao and our own postdoctoral Fish Hui Xian Poh for winning the best poster award at this year’s Singapore Scientific Conference!
December 12, 2025 at 8:53 AM
Congratulations to Wei Hao and our own postdoctoral Fish Hui Xian Poh for winning the best poster award at this year’s Singapore Scientific Conference!
Weekend in Tokyo ahead of meeting up with colleagues.
December 8, 2025 at 10:52 PM
Weekend in Tokyo ahead of meeting up with colleagues.
Congratulations to our phd student Thomas for winning the best poster prize at the Pasteur Cambodia Immunology course!!
November 30, 2025 at 4:03 AM
Congratulations to our phd student Thomas for winning the best poster prize at the Pasteur Cambodia Immunology course!!
Who remembers sequencing their molecular cloning experiments by hand and eye?!? Running your own acrylamide gels and reading the four bases from top to bottom of gel, to only get 200 nt read from a single mini prep hoping your insert was ok!?
November 28, 2025 at 3:38 AM
Who remembers sequencing their molecular cloning experiments by hand and eye?!? Running your own acrylamide gels and reading the four bases from top to bottom of gel, to only get 200 nt read from a single mini prep hoping your insert was ok!?
Happening now! Prof Yue WANG, our pillar of Fungal biology at ASTAR ID Labs, is celebrating over 4 decades of research in his last seminar before retirement. What a great life story!
November 28, 2025 at 3:29 AM
Happening now! Prof Yue WANG, our pillar of Fungal biology at ASTAR ID Labs, is celebrating over 4 decades of research in his last seminar before retirement. What a great life story!
This was an excellent talk by a brilliant scientist, Kei Sato, from University of Tokyo, opening up a second satellite lab at Duke-NUS! Great news for Singapore virology!
November 25, 2025 at 3:47 AM
This was an excellent talk by a brilliant scientist, Kei Sato, from University of Tokyo, opening up a second satellite lab at Duke-NUS! Great news for Singapore virology!
Tomorrow at IDLabs! 10am in Matrix building, Codon room
Seminar by Kei Sato!
Seminar by Kei Sato!
November 24, 2025 at 8:24 AM
Tomorrow at IDLabs! 10am in Matrix building, Codon room
Seminar by Kei Sato!
Seminar by Kei Sato!
Reposted by Vignuzzi Lab
This explains the recent outbreak of arts and crafts in @astar-idlabs.bsky.social @vignuzzilab.bsky.social @alnajifg.bsky.social
If you'd like to celebrate the biology of viruses - or the fight against viral diseases - this winter, try out our free and updated #VirusSnowflake designs.
Please share, and if you have any photos of Virus Snowflakes in your area it would be lovely to see them!
cvr-engagement.co.uk/virus-snowfl...
Please share, and if you have any photos of Virus Snowflakes in your area it would be lovely to see them!
cvr-engagement.co.uk/virus-snowfl...
November 19, 2025 at 3:13 AM
This explains the recent outbreak of arts and crafts in @astar-idlabs.bsky.social @vignuzzilab.bsky.social @alnajifg.bsky.social
This week, my lab, and research institute A*IDL, and A*STAR signed an ideation agreement with Flagship Pioneering Biotech and one of their portfolio companies Apriori to develop self-amplifying RNA vaccines for pandemic Flu threats. (1/3)
November 16, 2025 at 3:19 AM
This week, my lab, and research institute A*IDL, and A*STAR signed an ideation agreement with Flagship Pioneering Biotech and one of their portfolio companies Apriori to develop self-amplifying RNA vaccines for pandemic Flu threats. (1/3)
Reposted by Vignuzzi Lab
Sharing this, quite relevant this week. www.thelancet.com/journals/lan...
Remembering my sister Rosalind Franklin
Rosalind Franklin died of ovarian cancer in 1958 aged 37 years. Sympathy and feminism
have combined to give us her familiar image as a downtrodden woman scientist, brilliant
but neglected, a heroine t...
www.thelancet.com
November 8, 2025 at 10:25 AM
Sharing this, quite relevant this week. www.thelancet.com/journals/lan...
Szarina brought in virus snowflake cutout-yourself printouts to prepare for the Singapore winter and Christmas!
November 7, 2025 at 10:15 AM
Szarina brought in virus snowflake cutout-yourself printouts to prepare for the Singapore winter and Christmas!
Today we had a computational virology workshop with Profs. Veronika Bernhauerova (Charles University Czechia) and Bartek Lisowski (Jagiellonian University Krakow, Dr. Spyros Lytras (Univ Tokyo) and Cedric Tan (UCL Crick Institute). 4 hours of chit chat and coming up with ways to collaborate.
November 6, 2025 at 9:58 AM
Today we had a computational virology workshop with Profs. Veronika Bernhauerova (Charles University Czechia) and Bartek Lisowski (Jagiellonian University Krakow, Dr. Spyros Lytras (Univ Tokyo) and Cedric Tan (UCL Crick Institute). 4 hours of chit chat and coming up with ways to collaborate.