Vignuzzi Lab
@vignuzzilab.bsky.social
Antiviral therapeutics and virology. ASTAR ID Labs in Singapore.
A wonderful visit from Peggy, our lab’s retired admin assistant. She brought me my own name stamp in Chinese characters handmade in Shanghai ! ❤️
January 20, 2026 at 4:56 AM
A wonderful visit from Peggy, our lab’s retired admin assistant. She brought me my own name stamp in Chinese characters handmade in Shanghai ! ❤️
Happy birthday to Judy and Dinh! Celebrating with Galette des rois and Kouign amann during lab meeting.
January 17, 2026 at 1:54 AM
Happy birthday to Judy and Dinh! Celebrating with Galette des rois and Kouign amann during lab meeting.
I’m happy and proud to be part of this scientist’s career. First as research assistant, seeing him through an engineer’s degree, and now passing his PhD qualifying exam!
Bravo Thomas!
Bravo Thomas!
January 13, 2026 at 10:28 AM
I’m happy and proud to be part of this scientist’s career. First as research assistant, seeing him through an engineer’s degree, and now passing his PhD qualifying exam!
Bravo Thomas!
Bravo Thomas!
First lab meeting of 2026! And it was a great one, with beautiful results! These folks are brilliant! Bravo to Judy and Denzel for their beautiful work on alphavirus proteomics and flavivirus antivirals!
January 9, 2026 at 5:03 AM
First lab meeting of 2026! And it was a great one, with beautiful results! These folks are brilliant! Bravo to Judy and Denzel for their beautiful work on alphavirus proteomics and flavivirus antivirals!
Welcome to our lab Dylan Kwan, a coop exchange student from
Simon Fraser University in Canada!
Simon Fraser University in Canada!
January 5, 2026 at 6:50 AM
Welcome to our lab Dylan Kwan, a coop exchange student from
Simon Fraser University in Canada!
Simon Fraser University in Canada!
Congratulations to Wei Hao and our own postdoctoral Fish Hui Xian Poh for winning the best poster award at this year’s Singapore Scientific Conference!
December 12, 2025 at 8:53 AM
Congratulations to Wei Hao and our own postdoctoral Fish Hui Xian Poh for winning the best poster award at this year’s Singapore Scientific Conference!
Weekend in Tokyo ahead of meeting up with colleagues.
December 8, 2025 at 10:52 PM
Weekend in Tokyo ahead of meeting up with colleagues.
Congratulations to our phd student Thomas for winning the best poster prize at the Pasteur Cambodia Immunology course!!
November 30, 2025 at 4:03 AM
Congratulations to our phd student Thomas for winning the best poster prize at the Pasteur Cambodia Immunology course!!
Who remembers sequencing their molecular cloning experiments by hand and eye?!? Running your own acrylamide gels and reading the four bases from top to bottom of gel, to only get 200 nt read from a single mini prep hoping your insert was ok!?
November 28, 2025 at 3:38 AM
Who remembers sequencing their molecular cloning experiments by hand and eye?!? Running your own acrylamide gels and reading the four bases from top to bottom of gel, to only get 200 nt read from a single mini prep hoping your insert was ok!?
Happening now! Prof Yue WANG, our pillar of Fungal biology at ASTAR ID Labs, is celebrating over 4 decades of research in his last seminar before retirement. What a great life story!
November 28, 2025 at 3:29 AM
Happening now! Prof Yue WANG, our pillar of Fungal biology at ASTAR ID Labs, is celebrating over 4 decades of research in his last seminar before retirement. What a great life story!
This was an excellent talk by a brilliant scientist, Kei Sato, from University of Tokyo, opening up a second satellite lab at Duke-NUS! Great news for Singapore virology!
November 25, 2025 at 3:47 AM
This was an excellent talk by a brilliant scientist, Kei Sato, from University of Tokyo, opening up a second satellite lab at Duke-NUS! Great news for Singapore virology!
Tomorrow at IDLabs! 10am in Matrix building, Codon room
Seminar by Kei Sato!
Seminar by Kei Sato!
November 24, 2025 at 8:24 AM
Tomorrow at IDLabs! 10am in Matrix building, Codon room
Seminar by Kei Sato!
Seminar by Kei Sato!
This week, my lab, and research institute A*IDL, and A*STAR signed an ideation agreement with Flagship Pioneering Biotech and one of their portfolio companies Apriori to develop self-amplifying RNA vaccines for pandemic Flu threats. (1/3)
November 16, 2025 at 3:19 AM
This week, my lab, and research institute A*IDL, and A*STAR signed an ideation agreement with Flagship Pioneering Biotech and one of their portfolio companies Apriori to develop self-amplifying RNA vaccines for pandemic Flu threats. (1/3)
Szarina brought in virus snowflake cutout-yourself printouts to prepare for the Singapore winter and Christmas!
November 7, 2025 at 10:15 AM
Szarina brought in virus snowflake cutout-yourself printouts to prepare for the Singapore winter and Christmas!
Today we had a computational virology workshop with Profs. Veronika Bernhauerova (Charles University Czechia) and Bartek Lisowski (Jagiellonian University Krakow, Dr. Spyros Lytras (Univ Tokyo) and Cedric Tan (UCL Crick Institute). 4 hours of chit chat and coming up with ways to collaborate.
November 6, 2025 at 9:58 AM
Today we had a computational virology workshop with Profs. Veronika Bernhauerova (Charles University Czechia) and Bartek Lisowski (Jagiellonian University Krakow, Dr. Spyros Lytras (Univ Tokyo) and Cedric Tan (UCL Crick Institute). 4 hours of chit chat and coming up with ways to collaborate.
Afternoon coffee break at Top Coffee Shop in Asia, number 6 in the world, dunno who’s list but must be an important one: Apartment Cafe. With Veronika Bernhauerova from Charles University Czechia and Bartek Lisowski of Jagiellonian University in Krakow Poland.
November 4, 2025 at 10:46 AM
Afternoon coffee break at Top Coffee Shop in Asia, number 6 in the world, dunno who’s list but must be an important one: Apartment Cafe. With Veronika Bernhauerova from Charles University Czechia and Bartek Lisowski of Jagiellonian University in Krakow Poland.
Welcome to our lab Mingcong (Albert) to our lab! Albert is from Chengdu China and will be an intern in our lab for the next seven months working with Fadi Alnaji.
October 21, 2025 at 10:46 PM
Welcome to our lab Mingcong (Albert) to our lab! Albert is from Chengdu China and will be an intern in our lab for the next seven months working with Fadi Alnaji.
Happy Diwali
Happy Deepavali
To all celebrating in Singapore and beyond!
Happy Deepavali
To all celebrating in Singapore and beyond!
October 20, 2025 at 2:36 AM
Happy Diwali
Happy Deepavali
To all celebrating in Singapore and beyond!
Happy Deepavali
To all celebrating in Singapore and beyond!
Be positive. Love thyself. Try to love others too.
October 13, 2025 at 2:24 AM
Be positive. Love thyself. Try to love others too.
Happening now. Prof. Kartik Chandran, in Singapore this week for the HCV & Flaviviruses conference, is speaking to ID Labs scientists on their coronavirus research.
October 10, 2025 at 4:15 AM
Happening now. Prof. Kartik Chandran, in Singapore this week for the HCV & Flaviviruses conference, is speaking to ID Labs scientists on their coronavirus research.
Had a reminder by my colleague Amit Singhal that two years ago to this day our faculty had a retreat in my medieval village of Noyers-sur-Serein. Missing this clunky old house! 🏰 ❤️
October 6, 2025 at 2:03 AM
Had a reminder by my colleague Amit Singhal that two years ago to this day our faculty had a retreat in my medieval village of Noyers-sur-Serein. Missing this clunky old house! 🏰 ❤️
BUT now, a million years later, my lab is revisiting all this stuff, saRNA vaccines, bacterial delivery systems, oncolytic therapies, with a modern updated touch.
READ this very cool paper by SINGER et al, one of my favourites for 2025 for sure!
READ this very cool paper by SINGER et al, one of my favourites for 2025 for sure!
September 25, 2025 at 6:16 AM
BUT now, a million years later, my lab is revisiting all this stuff, saRNA vaccines, bacterial delivery systems, oncolytic therapies, with a modern updated touch.
READ this very cool paper by SINGER et al, one of my favourites for 2025 for sure!
READ this very cool paper by SINGER et al, one of my favourites for 2025 for sure!
To restrict the spread of the oncolytic virus, they swapped one protease cleavage sites with that of Tobacco Etch virus, so only cells expressing TEVpro from the Salmonella can produce full virus. Cool safety switch!
September 25, 2025 at 6:16 AM
To restrict the spread of the oncolytic virus, they swapped one protease cleavage sites with that of Tobacco Etch virus, so only cells expressing TEVpro from the Salmonella can produce full virus. Cool safety switch!
Impressively, these oncolytic viruses launched from T7 RNA promoter in Salmonella expressing T7 polymerase, significantly reduce tumours at the injection site and at other sites, fully protecting mice against the disease.
September 25, 2025 at 6:16 AM
Impressively, these oncolytic viruses launched from T7 RNA promoter in Salmonella expressing T7 polymerase, significantly reduce tumours at the injection site and at other sites, fully protecting mice against the disease.
They use this bacteria to invade a cell and deliver an oncolytic Senecavirus RNA, which replicates, and spreads to neighbouring tumours.
September 25, 2025 at 6:16 AM
They use this bacteria to invade a cell and deliver an oncolytic Senecavirus RNA, which replicates, and spreads to neighbouring tumours.