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Elliot Tucker-Drob @tuckerdrob.bsky.social · 6d

Non-paywalled link to my commentary on @vw1234.bsky.social and colleagues new paper in @nature.com rdcu.be/eI2NG

Reposted by Elliot Tucker-Drob

Varun Warrier @vw1234.bsky.social · 6d

This was a fantastic collaboration with lots of people including @hilarycmartin.bsky.social @jakobgrove.bsky.social, Experts by Experience, and several others who I can't seem to find on this app.

Article: www.nature.com/articles/s41...

Polygenic and developmental profiles of autism differ by age at diagnosis - Nature

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

www.nature.com

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Reposted by Elliot Tucker-Drob

Varun Warrier @vw1234.bsky.social · 6d

And a very helpful and informative commentary on the paper by @tuckerdrob.bsky.social www.nature.com/articles/d41...

Early- and late-diagnosed autism are genetically distinct

Analyses of symptoms and genomic data indicate that autism that manifests in early childhood is distinct from autism that is diagnosed later in development.

www.nature.com

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Reposted by Elliot Tucker-Drob

René Mõttus @renemottus.bsky.social · 20d

Keynote speakers: @tuckerdrob.bsky.social @foswald.bsky.social Ellen Hamaker

Hands-on workshops by:
@tedmond.bsky.social & @ukuvainik.bsky.social (genomic analyses)
@dirkwulff.bsky.social (LLMs in personality research)

www.ecp22edinburgh.org/programme

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Elliot Tucker-Drob @tuckerdrob.bsky.social · Aug 19

A deep and thought-provoking lecture that is definitely worth watching all the way through.

Eric Turkheimer @ent3c.bsky.social · Aug 18

My Dobzhansky lecture at BGA: "Theodosius Dobzhansky and the Origins of Radical Behavior Genetics" is publicly available. I talk about the tensions introduced into the field at the difficult border between science using model organisms and human beings. Thanks to BGA for the opportunity.

Sat_208_Dobzhansky_Lecture

Dobzhansky Lecture by Eric Turkheimer

vimeo.com

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Elliot Tucker-Drob @tuckerdrob.bsky.social · Aug 18

Let’s not “memory hole” the Flynn Effect, whereby objective cognitive measures show large mean cohort trends that are not plausibly reflective of any sort of general aspect of intelligence, but the individual correlates are largely invariant across generations.

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Elliot Tucker-Drob @tuckerdrob.bsky.social · Aug 18

But what is messy? What is late? Still subject to frame of reference.

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Elliot Tucker-Drob @tuckerdrob.bsky.social · Aug 18

Perhaps not peer comparison but shifting frame-of-reference, concept of normative or ideal, use of language… what @michelnivard.bsky.social likens to a vowel shift. Not necessarily the case, but important to consider, rather than trusting mean trends in self-report as veridical without question.

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Elliot Tucker-Drob @tuckerdrob.bsky.social · Aug 18

The interpretation is that the charter schools increase conscientiousness, self control, & grit... but also make students more self-critical with respect to those skills (perhaps they are cured of a Dunning-Krueger effect), such that self reports of those skills go down while the skills improve. 5/5

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Elliot Tucker-Drob @tuckerdrob.bsky.social · Aug 18

One of the coolest examples of this is a natural experiment (lottery study) for oversubscribed charter schools (doi.org/10.3102/0162...). The charter schools increased student achievement but reduced self-reported noncognitive skills that are known to relate to achievement. 4/

Promise and Paradox - Martin R. West, Matthew A. Kraft, Amy S. Finn, Rebecca E. Martin, Angela L. Duckworth, Christopher F. O. Gabrieli, John D. E. Gabrieli, 2016

We used self-report surveys to gather information on a broad set of non-cognitive skills from 1,368 eighth graders. At the student level, scales measuring consc...

doi.org

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Elliot Tucker-Drob @tuckerdrob.bsky.social · Aug 18

they may be misleading when comparing across cultures, cohorts, or possibly developmental periods due to different ways that people interpret the questions and use the likert scales, reference bias, etc... 3/

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Elliot Tucker-Drob @tuckerdrob.bsky.social · Aug 18

Unfortunately, "objective" observation- and task-based methods for measuring personality have much weaker construct validity and criterion validity. While self-reports are a great way to measure individual differences in personality among people matched on culture and context... 2/

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Elliot Tucker-Drob @tuckerdrob.bsky.social · Aug 18

A few related conversations have been converging on the question of when various trends and observations with respect to personality are genuine. This is a complex issue without a simple answer... A key issue is that personality is best measured using self- or informant ratings... 1/

Michel Nivard @michelnivard.bsky.social · Aug 17

While I am not entirely convinced this is “real” and not some psychometric equivalent of a vowel shift (and PRS could help find out a bit I think) this it is relevant:

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Elliot Tucker-Drob @tuckerdrob.bsky.social · Aug 18

The twin/family studies were not clear whether it was dominance vs. epistasis vs. some other sort of nonadditivity. Dominance was just the easiest to model. We can now estimate dominance SNP h2 but can’t obtain an estimate of epistatic SNP h2. Assimilation/contrast effects may also be at play.

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Elliot Tucker-Drob @tuckerdrob.bsky.social · Aug 18

To close the loop on this, this is what we wrote in the review (originally posted on the other platform).

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Reposted by Elliot Tucker-Drob

Awais Aftab @awaisaftab.bsky.social · Jul 19

Psychiatric Genetics Beyond Heritability: Q&A with Michel Nivard ( @michelnivard.bsky.social )

“We look for genes as a means to an end—biology, epidemiology, and etiology of complex human outcomes.”

www.psychiatrymargins.com/p/psychiatri...

Psychiatric Genetics Beyond Heritability: Q&A with Michel Nivard

We look for genes as a means to an end—biology, epidemiology, and etiology of complex human outcomes.

www.psychiatrymargins.com

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Reposted by Elliot Tucker-Drob

Laurel Raffington @laraffington.bsky.social · Jul 3

Humbled to receive the BGA's early career award ☺️ Thank you to my brilliant team #MPRGBiosocial, the @maxplanck.de for investing in early career researchers, @mpib-berlin.bsky.social for the excellent environment, and my many mentors incl @kph3k.bsky.social @tuckerdrob.bsky.social #ScienceTeamSport

Behavior Genetics Association @behaviorgenetic.bsky.social · Jul 2

🏆 @laraffington.bsky.social‬ won the early career award, and Paul Liechtenstein won the Dobzhansky award

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Elliot Tucker-Drob @tuckerdrob.bsky.social · May 20

Omg 😂. Well played @michelnivard.bsky.social

Michel Nivard @michelnivard.bsky.social · May 20

O, right I promissed JUICE! Not everyone believes in this work, one of the "haters" was very early... In fact @ent3c.bsky.social practically leant over this papers' crib and said: "well that's not going to be a looker."... Someone just as petty as me, but far more organized, kept the receipts 👇

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Reposted by Elliot Tucker-Drob

Michel Nivard @michelnivard.bsky.social · May 20

O, right I promissed JUICE! Not everyone believes in this work, one of the "haters" was very early... In fact @ent3c.bsky.social practically leant over this papers' crib and said: "well that's not going to be a looker."... Someone just as petty as me, but far more organized, kept the receipts 👇

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Reposted by Elliot Tucker-Drob

Michel Nivard @michelnivard.bsky.social · May 20

You will have seen this post by @tedmond.bsky.social‬ on our new GWAS of Personality. He says you should read the paper (you should), I want to write a thread to entice you. Because social media has shredded your attention as it has mine, I promise there is JUICE & BEEF in this thread!

Ted Schwaba @tedmond.bsky.social · May 20

Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...

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Reposted by Elliot Tucker-Drob

Hans Fredrik Sunde @hfsunde.bsky.social · May 20

Probably the most important paper in personality psych this decade just dropped. 👀 Interesting genetic correlations between other traits (the #1 reason for GWASs on social traits IMO), and evidence of weak but non-zero assortative mating on personality.

Ted Schwaba @tedmond.bsky.social · May 20

Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...

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Reposted by Elliot Tucker-Drob

Michel Nivard @michelnivard.bsky.social · May 20

🔥🔥🔥 2 years of our lives right there (extremely proud of everyone, I’ll write a thread later)

Ted Schwaba @tedmond.bsky.social · May 20

Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...

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Reposted by Elliot Tucker-Drob

Ted Schwaba @tedmond.bsky.social · May 20

Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...

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Reposted by Elliot Tucker-Drob

Aysu Okbay @aysuo.bsky.social · May 20

PGI Repository v2.0 preprint out! A 🧵 on the main results and updates @robel-alemu.bsky.social @paturley.bsky.social @alextisyoung.bsky.social

bioRxivpreprint @biorxivpreprint.bsky.social · May 19

An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference https://www.biorxiv.org/content/10.1101/2025.05.14.653986v1

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Reposted by Elliot Tucker-Drob

Michel Nivard @michelnivard.bsky.social · May 16

Super brief video intro-ing the alpha version(!!) of an free studyguide/book in sequence models and deeplearning in/for genomics.

Alpha version of my new book on ML in Genomics is online!

YouTube video by Michel's Science Speedrun

www.youtube.com

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