Twist Bioscience
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Synthetic DNA for Health & Sustainability
Read the paper here: www.nature.com/articles/s44...
Thank you to the authors for choosing @twistbioscience.com DNA to support this work!
Thank you to the authors for choosing @twistbioscience.com DNA to support this work!
January 8, 2026 at 2:44 PM
Read the paper here: www.nature.com/articles/s44...
Thank you to the authors for choosing @twistbioscience.com DNA to support this work!
Thank you to the authors for choosing @twistbioscience.com DNA to support this work!
> Genome Modeling and Design: From the Molecular to Genome Scale: www.twistbioscience.com/resources/we...
> Accelerating Recombinase Reprogramming with Machine Learning: www.twistbioscience.com/resources/we...
> Accelerating Recombinase Reprogramming with Machine Learning: www.twistbioscience.com/resources/we...
Genome Modeling and Design: From the Molecular to Genome Scale | Twist Bioscience
Brian Hie at Stanford discusses training Evo2, a genomic foundation model, with 9.3 trillion nucleotides from over 128,000 genomes.
www.twistbioscience.com
January 7, 2026 at 2:58 PM
> Genome Modeling and Design: From the Molecular to Genome Scale: www.twistbioscience.com/resources/we...
> Accelerating Recombinase Reprogramming with Machine Learning: www.twistbioscience.com/resources/we...
> Accelerating Recombinase Reprogramming with Machine Learning: www.twistbioscience.com/resources/we...
> A CRE.AI.TIVE application of Al: Engineering a more resilient global food supply: www.twistbioscience.com/resources/ca...
> Resurrecting Plant Defense Mechanisms to Avoid Crop Pathogens: www.twistbioscience.com/resources/we...
> Resurrecting Plant Defense Mechanisms to Avoid Crop Pathogens: www.twistbioscience.com/resources/we...
A CRE.AI.TIVE application of AI: Engineering a more resilient global food supply | Twist Bioscience
Using oligo pools, Phytoform Labs screened thousands of AI-designed DNA sequences—streamlining trait engineering, accelerating crop improvement, and optimizing R&D resources
www.twistbioscience.com
January 7, 2026 at 2:58 PM
> A CRE.AI.TIVE application of Al: Engineering a more resilient global food supply: www.twistbioscience.com/resources/ca...
> Resurrecting Plant Defense Mechanisms to Avoid Crop Pathogens: www.twistbioscience.com/resources/we...
> Resurrecting Plant Defense Mechanisms to Avoid Crop Pathogens: www.twistbioscience.com/resources/we...
> Building Better Al With High-Resolution Functional Genomics Data: www.twistbioscience.com/resources/we...
> Using Al to design proteins that inhibit bacterial heme-piracy: www.twistbioscience.com/resources/we...
> Using Al to design proteins that inhibit bacterial heme-piracy: www.twistbioscience.com/resources/we...
Building Better AI With High-Resolution Functional Genomics Data | Twist Bioscience
Ci Chu at Xaira explores new approaches to generating large-scale, single-cell perturbation datasets that overcome key challenges in throughput, variability and batch effects.
www.twistbioscience.com
January 7, 2026 at 2:58 PM
> Building Better Al With High-Resolution Functional Genomics Data: www.twistbioscience.com/resources/we...
> Using Al to design proteins that inhibit bacterial heme-piracy: www.twistbioscience.com/resources/we...
> Using Al to design proteins that inhibit bacterial heme-piracy: www.twistbioscience.com/resources/we...
From RAND comes one of the most important biosecurity briefs of 2025:
“Legitimate Research or Biological Threat? Detecting Misuse of the Biological Supply Network and Policy Options to Reduce Risks“
“Legitimate Research or Biological Threat? Detecting Misuse of the Biological Supply Network and Policy Options to Reduce Risks“
Legitimate Research or Biological Threat? Detecting Misuse of the Biological Supply Network and Policy Options to Reduce Risks
This research brief highlights the critical points and mitigation strategies that RAND researchers made in their report about how bad actors could exploit the biological supply network to develop biol...
www.rand.org
December 29, 2025 at 3:03 PM
From RAND comes one of the most important biosecurity briefs of 2025:
“Legitimate Research or Biological Threat? Detecting Misuse of the Biological Supply Network and Policy Options to Reduce Risks“
“Legitimate Research or Biological Threat? Detecting Misuse of the Biological Supply Network and Policy Options to Reduce Risks“
From David R Liu and team, prime editing-mediated readthrough of premature termination codons (PERT): “Prime editing-installed suppressor tRNAs for disease-agnostic genome editing.” www.nature.com/articles/s41...
Prime editing-installed suppressor tRNAs for disease-agnostic genome editing - Nature
A new strategy that uses prime editing to convert an endogenous tRNA into a suppressor tRNA shows therapeutic potential for multiple genetic diseases that are caused by premature stop codons.
www.nature.com
December 29, 2025 at 3:02 PM
From David R Liu and team, prime editing-mediated readthrough of premature termination codons (PERT): “Prime editing-installed suppressor tRNAs for disease-agnostic genome editing.” www.nature.com/articles/s41...
Sarel Fleishman, Ariel Tennenhouse, and team developed a principled structure- and energy-based strategy, called CADAbRe, for designing repertoires of human antibodies that are stable by design.
“Structure-based design of antibody repertoires with drug-like properties”
“Structure-based design of antibody repertoires with drug-like properties”
Structure-based design of antibody repertoires with drug-like properties
Animal immunization is the prevalent strategy for discovering antibody therapeutics, but it is a lengthy and poorly controlled process. As an alternative, antibody repertoires can be synthesized by re...
www.biorxiv.org
December 29, 2025 at 3:02 PM
Sarel Fleishman, Ariel Tennenhouse, and team developed a principled structure- and energy-based strategy, called CADAbRe, for designing repertoires of human antibodies that are stable by design.
“Structure-based design of antibody repertoires with drug-like properties”
“Structure-based design of antibody repertoires with drug-like properties”
David Baker’s lab at the Institute for Protein Design, University of Washington has developed AI designed antibodies from scratch. Read “Atomically accurate de novo design of antibodies with RFdiffusion” here:
Atomically accurate de novo design of antibodies with RFdiffusion - Nature
The combination of computational design, laboratory-based screening and biophysical validation enables the de novo generation of variable heavy-chain antibody fragments and antibodies that precis...
www.nature.com
December 29, 2025 at 3:01 PM
David Baker’s lab at the Institute for Protein Design, University of Washington has developed AI designed antibodies from scratch. Read “Atomically accurate de novo design of antibodies with RFdiffusion” here:
BindCraft, an open-source and automated pipeline for de novo protein binder design is presented by Bruno Correia, Martin Pacesa, Lennart Nickel, and Christian Schellhaas:
“One-shot design of functional protein binders with BindCraft”
“One-shot design of functional protein binders with BindCraft”
One-shot design of functional protein binders with BindCraft - Nature
BindCraft, an open-source, automated pipeline for de novo protein binder design with experimental success rates of 10–100%, leverages AlphaFold2 weights to generate binders with nanomolar affinity wit...
www.nature.com
December 29, 2025 at 3:00 PM
BindCraft, an open-source and automated pipeline for de novo protein binder design is presented by Bruno Correia, Martin Pacesa, Lennart Nickel, and Christian Schellhaas:
“One-shot design of functional protein binders with BindCraft”
“One-shot design of functional protein binders with BindCraft”
François Boemer & team demonstrate the importance of integrating biochemical & genomic methods in NBS programs as they report the results of the first 18 months of the ongoing observational study BabyDetect. Read “Population-based, first-tier genomic newborn screening in the maternity ward” here:
Population-based, first-tier genomic newborn screening in the maternity ward - Nature Medicine
The BabyDetect project offered expanded newborn genomic screening covering more than 400 genes to 4,260 families, leading to 71 clinical diagnoses.
www.nature.com
December 29, 2025 at 2:56 PM
François Boemer & team demonstrate the importance of integrating biochemical & genomic methods in NBS programs as they report the results of the first 18 months of the ongoing observational study BabyDetect. Read “Population-based, first-tier genomic newborn screening in the maternity ward” here:
🧪 A Simple Guide to Phosphoramidite Chemistry and How it Fits in Twist Bioscience's Commercial Engine…
Phosphoramidite Chemistry for DNA Synthesis | Twist Bioscience
Phosphoramidite chemistry is the gold standard method for DNA synthesis that has been used in the industry for almost 35 years. Since its discovery, its simplicity and high efficiency have allowed lar...
www.twistbioscience.com
December 26, 2025 at 2:17 PM
🧪 A Simple Guide to Phosphoramidite Chemistry and How it Fits in Twist Bioscience's Commercial Engine…
🧬 Moving Beyond 300 Base Pairs…
Moving Beyond 300 Base Pairs | Twist Bioscience
In a recent episode of the podcast series Lab Talk by The Scientist, guest speaker Josh Tycko’s excitement was infectious. Tycko, a postdoctoral researcher at Harvard Medical School, spoke about how f...
www.twistbioscience.com
December 26, 2025 at 2:17 PM
🧬 Moving Beyond 300 Base Pairs…
👨🏫 Expert View- Julian Jude on The New Functional Genomics Era…
Expert View: Julian Jude on The New Functional Genomics Era | Twist Bioscience
Now more than ever, functional genomics studies can be carried out at scale and at speed. Era-defining advancements (like AI and CRISPR tools) are only possible thanks to parallel advances in syntheti...
www.twistbioscience.com
December 26, 2025 at 2:17 PM
👨🏫 Expert View- Julian Jude on The New Functional Genomics Era…
🐄 Combatting Global Warming With A $4.3 Million Heifer…
Combatting Global Warming With A $4.3 Million Heifer | Twist Bioscience
Viatina's impressive stature has made her a prized member of her species worth roughly $4.3 million dollars, qualifying her as the world’s most valuable cow. But the true source of her worth comes fro...
www.twistbioscience.com
December 26, 2025 at 2:16 PM
🐄 Combatting Global Warming With A $4.3 Million Heifer…