Lightnews — Scholar-powered news

Reposted by Ty Miller Lab

dkotliar.bsky.social @dkotliar.bsky.social · Sep 3

We also made a website and python API to run starCAT with several other published gene program catalogs including a myeloid reference from @tymillerlab.bsky.social et al and a hematapoetic stem cell reference from @bloodandtime.bsky.social and Hojun Li

1 1 4

Reposted by Ty Miller Lab

Case Comprehensive Cancer Center @caseccc.bsky.social · Aug 22

Case CCC/@uhcleveland.bsky.social researcher @tymillerlab.bsky.social targets myeloid cells in brain cancer www.uhhospitals.org/for-clinicia...

UH Seidman Researcher Parlaying Findings in Nature into More Effective Immunotherapy for Brain Tumors, Targeting Myeloid Cells

A major impediment to the successful use of immunotherapy in glioblastoma is the preponderance of a type of immune cell in the tumor, called myeloid cells, which can make up as much as 50% of all cell...

www.uhhospitals.org

1 1

Ty Miller Lab @tymillerlab.bsky.social · Aug 12

Home cooked meals are the best.
Grateful to have @vrishab_x's mother visit the lab from Seattle and cook us all authentic South Indian food for lunch today 😋❤️

4

Ty Miller Lab @tymillerlab.bsky.social · Aug 6

Celebrating "UH100", the 100th brain tumor we've collected (in ~10 months!) & processed to learn more about these tumors & make patient organoids to test new therapies @uhreinstitute.bsky.social & @caseccc.bsky.social. Thanks to the patients, @staudtmd.bsky.social & Dr. Tiffany Hodges, & my lab!

1 5

Ty Miller Lab @tymillerlab.bsky.social · Jun 24

Congratulations to @terminallycurious.bsky.social, Huang-lab MSTP student @CWRU, on her main thesis project!! Very happy we could help support her great story as our lab's first collaborative project. Turns out mechano-sensors are important in tumor-associated myeloid cells!
@caseccc.bsky.social

Melissa Bonner @terminallycurious.bsky.social · Jun 24

I am excited to share my work which demonstrates that deletion of PIEZO1 surprisingly enhances cross-priming in tumor-associated myeloid cells. Thank you to @tymillerlab.bsky.social for your critical collaboration and @sitcancer.bsky.social for publishing my story!

jitc.bmj.com/content/13/6...

Piezo1 deletion enhances cross-priming of CD8+ T cells by tumor-infiltrating CD11b+ dendritic cells

Background Tumor-associated myeloid cells (TAMCs) are an abundant, phenotypically plastic cell population that is critical for initiating a robust antitumor response. To properly combat cancer cells, ...

jitc.bmj.com

2 3

Reposted by Ty Miller Lab

Melissa Bonner @terminallycurious.bsky.social · Jun 24

I am excited to share my work which demonstrates that deletion of PIEZO1 surprisingly enhances cross-priming in tumor-associated myeloid cells. Thank you to @tymillerlab.bsky.social for your critical collaboration and @sitcancer.bsky.social for publishing my story!

jitc.bmj.com/content/13/6...

Piezo1 deletion enhances cross-priming of CD8+ T cells by tumor-infiltrating CD11b+ dendritic cells

Background Tumor-associated myeloid cells (TAMCs) are an abundant, phenotypically plastic cell population that is critical for initiating a robust antitumor response. To properly combat cancer cells, ...

jitc.bmj.com

1 2 3

Ty Miller Lab @tymillerlab.bsky.social · Apr 30

Congratulations John! So well deserved!

Also, appreciate your voice and advocacy during this crazy time

2

Ty Miller Lab @tymillerlab.bsky.social · Apr 30

This couldn't have better timing. Was just strategizing today with my MSTP student on creating a binder for a new target. Thanks for creating this!

1 2

Ty Miller Lab @tymillerlab.bsky.social · Apr 30

Thanks! We have an online tool that will calculate the program usage in your cells. Just need your gene expression matrix. Will be more accurate than using module scoring of the top 100 genes. Let me know if you have any issues!

1

Reposted by Ty Miller Lab

RTN Conference @rtnconference.bsky.social · Apr 16

🚨Registrations now live!
Check out this amazing line up of speakers at #RTN #ReThinkNeuroimmunology organised by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Register here: genelayinstitute.org/rtn/

1 9 9

Ty Miller Lab @tymillerlab.bsky.social · Apr 16

A real privilege to be part of this meeting with so many leaders in the field that I admire. It is an inspiring group of passionate & dedicated physicians/scientists trying to tackle #GBM. Hoping that our collective efforts will lead to effective therapies for these patients. Thanks for the invite!

Banbury Center @cshlbanbury.bsky.social · Apr 15

Thank you to participants of "Glioblastoma" for productive and invigorating discussions, with special thanks to organizers Drs. Melissa Bondy, Peter Dirks, and Bill Weiss. We are grateful to the @cshlnews.bsky.social - @northwellhealth.bsky.social Affiliation for support.

Agenda: bit.ly/GBM-25

Group of 23 participants on the patio outside the conference center.

1 1 4

Ty Miller Lab @tymillerlab.bsky.social · Apr 15

Thanks @sitcancer.bsky.social!

1

Ty Miller Lab @tymillerlab.bsky.social · Apr 15

2. Brain Tumor Immunology Postdoc: Perfect for individuals passionate about developing cutting-edge spatial transcriptomics, multiplex immunofluorescence technologies, & bioinformatics to decode tumor-immune interactions
case.edu/academic-car...
@braintumourcharity.bsky.social
@theabta.bsky.social

Postdoctoral Scholar - Cancer Immunotherapy | Academic Careers | Case Western Reserve University

Entry Date: January 2025 Job code and Title: Postdoctoral Scholar Department ID and Name: 694060 Pathology School: Medicine Location: Wolstein Researc...

case.edu

2

Ty Miller Lab @tymillerlab.bsky.social · Apr 15

1. CAR-T Cell Immunotherapy Postdoc: Ideal for candidates with expertise in CAR-T cell engineering and tumor immunology, eager to translate innovative therapies from the bench to clinical application. case.edu/academic-car...
#immunotherapy #CAR_T
@sitcancer.bsky.social

CAR-T Cancer Immunotherapy | Academic Careers | Case Western Reserve University

Entry Date: January 2025 Job code and Title: Postdoctoral Scholar Department ID and Name: 694060 Pathology School: Medicine Location: Wolstein Researc...

case.edu

1 1 1

Ty Miller Lab @tymillerlab.bsky.social · Apr 15

Our lab @caseccc.bsky.social, CWRU SOM, & University Hospitals is recruiting! We are looking for 2 talented immunotherapy postdocs eager to make an impact for brain tumor patients using cutting edge single-cell & spatial genomics & patient-tissue organoids - join us!
Please share positions below:

We have a fun, collaborative group that includes medical and graduate students, staff, residents/fellows, neurosurgeons, neuro-oncologists and neuro-pathologists. Picture from lab holiday party at my house with our close collaborators - Dr. Tiffany Hodges (leader of brain tumor neurosurgery at UH) and Dr. Herb Newton (head of neuro-oncology at UH).

1 4

Ty Miller Lab @tymillerlab.bsky.social · Mar 31

Honored for our lab to be highlighted in the @caseccc.bsky.social annual report - I can't say enough great things about the environment and support for our new lab. 9 months in and so happy to be @CWRUSOM and @caseccc! A couple pictures in the lab that didn't make the report:

3

Ty Miller Lab @tymillerlab.bsky.social · Mar 22

Celebrating two summer fellowships today with ice cream @ Mitchells! Congrats to Kaylie for being awarded the CanSUR fellowship for undergraduates and Medical student Alex Wang the @caseccc.bsky.social Medical Training Award! Both awards will support their work in the lab this summer 🔬

1

Ty Miller Lab @tymillerlab.bsky.social · Mar 14

Was great to see friends and colleagues in London as part of the @braintumourcharity.bsky.social annual Scientific Advisory Board meeting! There are exciting things happening in brain tumor research around the world and honored to get to help guide it. Views were pretty good toon

1

Ty Miller Lab @tymillerlab.bsky.social · Mar 2

Thanks @lauritzmiarka.bsky.social!

Ty Miller Lab @tymillerlab.bsky.social · Feb 27

Thanks so much @leilaakkari.bsky.social! Thanks also for providing great feedback as a reviewer - the manuscript improved significantly since the initial submission! Appreciate your time and insights

2

Ty Miller Lab @tymillerlab.bsky.social · Feb 27

Thanks so much @sitcancer.bsky.social! SITC was a huge part of my evolution into the immunotherapy space. I took part in #Sparkathon (🙏 @jguerriero.bsky.social), met lots of leaders and peers, have been to the last 4 annual meetings, and was awarded the SITC-BMS fellowship to help support this work!

2 4

Ty Miller Lab @tymillerlab.bsky.social · Feb 27

Thanks Chris!!

1

Ty Miller Lab @tymillerlab.bsky.social · Feb 27

Thanks Brian!!

Reposted by Ty Miller Lab

Broad Institute @broadinstitute.org · Feb 26

New research uncovers four gene expression “programs” in immune cells that either suppress the immune system or make it more active — and could explain why brain cancer is often resistant to immunotherapy.

@danafarbernews.bsky.social @nature.com

Why brain cancer is often resistant to immunotherapy

Researchers find four coordinated gene expression programs in immune cells from glioma tumors, including two that could lead to immunotherapy resistance.

www.broadinstitute.org

1 3 11

Ty Miller Lab @tymillerlab.bsky.social · Feb 27

Especially in this uncertain time of federal funding, having support from other sources can be the difference between making discoveries or shutting projects down. If you are interested in supporting our work, we would be grateful for any contribution you can make! Reach out tymillerlab.org

Ty Miller Lab

From Science to Solutions: We focus on transforming our scientific insights into tangible treatments that improve patient outcomes. This takes a dedicated community working together and bright, young ...

tymillerlab.org

1