Lightnews — Scholar-powered news

Ubellacker Lab @ubellackerlab.bsky.social · Aug 19

Thank you, James! 😊

Ubellacker Lab @ubellackerlab.bsky.social · Aug 18

Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV

2 12 33

Ubellacker Lab @ubellackerlab.bsky.social · Aug 13

Fantastic lymph node protocols from @retickerflynn.bsky.social Lab, Cort Breuer, and team. Check it out!

Nathan Reticker-Flynn @retickerflynn.bsky.social · Aug 13

Interested in studying lymph node metastasis? Check out our protocol by Cort Breuer out today in @natprot.nature.com
bsky.app/profile/nat...

Nature Protocols (@natprot.nature.com)

New Article! Spontaneous and experimental models of lymph node metastasis https://bit.ly/4fzWoAj

bsky.app

2 4

Reposted by Ubellacker Lab

Nathan Reticker-Flynn @retickerflynn.bsky.social · Aug 13

Interested in studying lymph node metastasis? Check out our protocol by Cort Breuer out today in @natprot.nature.com
bsky.app/profile/nat...

Nature Protocols (@natprot.nature.com)

New Article! Spontaneous and experimental models of lymph node metastasis https://bit.ly/4fzWoAj

bsky.app

1 5 9

Reposted by Ubellacker Lab

Nature Protocols @natprot.nature.com · Aug 13

New Article! Spontaneous and experimental models of lymph node metastasis

Spontaneous and experimental models of lymph node metastasis

Nature Protocols, Published online: 13 August 2025; doi:10.1038/s41596-025-01200-5We provide two procedures to cover distinct approaches for the initiation of lymph node metastases in mice: one for studying the metastatic cascade in tumorigenic cells and the other for studying the effect of metastatic formations in the host.

bit.ly

4 8

Ubellacker Lab @ubellackerlab.bsky.social · Aug 10

Truly honored to receive this FASEB award! I am very grateful to be part of the welcoming & supportive ferroptosis community and am appreciative of this kind recognition! Thank you ~

2

Reposted by Ubellacker Lab

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Aug 6

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance https://www.biorxiv.org/content/10.1101/2025.08.05.668651v1

5 13

Reposted by Ubellacker Lab

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Aug 6

Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis https://www.biorxiv.org/content/10.1101/2025.08.05.668752v1

5 7

Ubellacker Lab @ubellackerlab.bsky.social · Aug 5

Join me in Boston October 6th for a 1-day conference on #mappingbiology to transform #cancertherapeutics. Register by September 25th to benefit from the complimentary (free) admission! Topics, speakers, and talk opportunities here: abcam.me/mappingbiolo...
@abcamofficial.bsky.social

4 7

Ubellacker Lab @ubellackerlab.bsky.social · Aug 2

Awesome study, congrats to all! 🎉

Reposted by Ubellacker Lab

DeBerardinis Lab at UT Southwestern Medical Center @rjdlab.bsky.social · Jul 29

1/Patient-derived xenografts (PDXs) are used in preclinical testing of cancer therapies, including metabolic therapies. We determined which metabolic properties are retained, and which are lost, when melanomas from patients are implanted and passaged as PDXs in mice.
www.nature.com/articles/s42...

Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts - Nature Metabolism

Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.

www.nature.com

4 19 55

Ubellacker Lab @ubellackerlab.bsky.social · Aug 1

Huge thank you to @olzmannlab.bsky.social and Scott Dixon for a phenomenal 1st FASEB Ferroptosis conference! I’m grateful to be part of such a collaborative community and it was especially great to meet all the brilliant trainees whose insights are clearly shaping the exciting future of the field! 🎉

James Olzmann @olzmannlab.bsky.social · Aug 1

The first FASEB Ferroptosis conference! ✔️ Thank you to my co-organizer Scott Dixon, our sponsors, and the whole #Ferroptosis community for showing up and making this such a wonderful meeting! 🤩 ❤️

2 12

Ubellacker Lab @ubellackerlab.bsky.social · Jul 11

Wow, super cool findings for targeting FSP1/the immune system in ferroptosis! 🎉

1 2

Reposted by Ubellacker Lab

James Olzmann @olzmannlab.bsky.social · Jul 11

New preprint w/ the Dupage lab led by @jgcastillo.bsky.social! FSP1 KO in Tregs / Tcells promotes tumor suppression, highlighting the therapeutic value potential of FSP1 inhibition. New paradigm for targeting ferroptosis in immune system (not just in cancer cells). 🤩
www.biorxiv.org/content/10.1...

Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity

A burgeoning approach to treat cancer is the pharmacological induction of ferroptotic cell death of tumor cells. However, the impact of disrupting anti-ferroptotic pathways in the broader tumor microe...

www.biorxiv.org

2 6 22

Ubellacker Lab @ubellackerlab.bsky.social · Jun 27

So lucky to have you onboard as the first founding postdoc of the ULab, @mariesabatier.bsky.social, to help build the lab from the beginning!

1

Ubellacker Lab @ubellackerlab.bsky.social · Jun 25

It’s over 100°F in Boston, and though both the weather and funding climates are intense, we took a well-deserved ice cream break to celebrate the progress, and the incredible people past and present, behind it all. Happy 3rd birthday, ULab! 🎉

1 15

Ubellacker Lab @ubellackerlab.bsky.social · Jun 13

Congrats on this fantastic work! 🎉

1 1

Ubellacker Lab @ubellackerlab.bsky.social · May 29

Congratulations, super exciting work! 🎉

3

Reposted by Ubellacker Lab

James Olzmann @olzmannlab.bsky.social · May 29

Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
1/9

Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1 | PNAS

FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...

www.pnas.org

12 29 76

Ubellacker Lab @ubellackerlab.bsky.social · May 27

Join us next Monday: June 2, 3-4PM off the Harvard Longwood Quad for two great cell death discussions on ferroptosis in breast cancer metastasis from
@mariesabatier.bsky.social
(Ubellacker Lab) and on thiol-reductive stress from Maolin Ge (Bar-Peled Lab)!

Ubellacker Lab @ubellackerlab.bsky.social · May 14

Join us June 2, 3-4PM off the Harvard Longwood Quad for two great cell death discussions on ferroptosis in breast cancer metastasis from @mariesabatier.bsky.social (Ubellacker Lab) and on thiol-reductive stress from Maolin Ge (Bar-Peled Lab)

1 1

Reposted by Ubellacker Lab

Harvard T.H. Chan School of Public Health @hsph.harvard.edu · May 20

Harvard Chan scientists participate in a rigorous application process for federal grants to conduct their vital health research. The government has now terminated nearly every single one of those grants.

2 35 84

Reposted by Ubellacker Lab

Brendan Manning @bdmanning.bsky.social · May 21

Indeed, our Outstanding Investigator Award from the National Cancer Institute, which funded all research personnel and activities in my modest-sized lab of 5 has been unceremoniously terminated.

Harvard T.H. Chan School of Public Health @hsph.harvard.edu · May 20

Harvard Chan scientists participate in a rigorous application process for federal grants to conduct their vital health research. The government has now terminated nearly every single one of those grants.

1 2 6

Ubellacker Lab @ubellackerlab.bsky.social · May 22

Way-to-go Alanis Carmona and Lewis Hendrianto for your incredible posters today at the Landry Cancer Biology Consortium, and shout-out to Alanis on your Karin Grunebaum Cancer Research Foundation Rising Young Scientist Award!

1 3

Ubellacker Lab @ubellackerlab.bsky.social · May 14

Join us June 2, 3-4PM off the Harvard Longwood Quad for two great cell death discussions on ferroptosis in breast cancer metastasis from @mariesabatier.bsky.social (Ubellacker Lab) and on thiol-reductive stress from Maolin Ge (Bar-Peled Lab)

3 2

Ubellacker Lab @ubellackerlab.bsky.social · May 13

Fantastic visit yesterday from the great Scott Dixon as part of our Cutter Distinguished Lecture on Molecular Metabolism series. An honor to host such an outstanding scientist and mentor to so many in the cell death field!

7