Bakar Aging Research Institute
@ucsfaging.bsky.social
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ucsfaging.bsky.social
It's wonderful to see the number of outstanding applicants increase each year for our graduate student fellowships in collaboration with the UCSF Hillblom Center for the Biology of Aging. Congrats to this year's recipients! #GeroSky #SciSky
ucsfaging.bsky.social
A recent manuscript published in @jclinical-invest.bsky.social led by Preeti Yadav from Mallar Bhattacharya's lab in collaboration with other BARI colleagues identifies an #immune-mesenchymal circuit that fuels fibrotic metabolism in #lung_fibrosis. bit.ly/4gmuiZM
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Reposted by Bakar Aging Research Institute
ucsfaging.bsky.social
Anudari Letian and the Goldberg Lab investigated how #neutrophils acquire #lipids from their environment and how this influences their functionality. Neutrophil-deficient mice showed protection against #atherosclerosis. Check on the article on bioRxiv here: bit.ly/3H9E3x5
Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth
Neutrophils are short-lived cells that are produced by the billions every day to circulate throughout the body and surveil all tissues. They are a key component of the innate immune system that play e...
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ucsfaging.bsky.social
We are thrilled to announce the awardees of our postdoctoral fellowships! Please join us in congratulating Ting Gong, @marioruizperez.bsky.social, Claire Huguenard, PhD, Hayden Holmlund, and Michaelangelo Gonzatti. 🎉
ucsfaging.bsky.social
📣 We are thrilled to announce @denadubal.bsky.social is joining our Executive Committee! Dr. Dubal's research investigates the molecular mechanisms of #aging, #resilience, and #neurodegenerative_disease. #SciSky #GeroSky
ucsfaging.bsky.social
Frailty in lung transplant patients is linked to anemia and telomere dysfunction. A study by John Greenland found that epigenetic aging correlated with chronological age, and not with frailty, highlighting the importance of telomere dysfunction and anemia in this patient population. bit.ly/4mvBgyi
Frailty in lung transplant recipients is associated with anemia and telomere dysfunction but independent of epigenetic age
Frailty is a syndrome of vulnerability to stressors linked to worse outcomes pre- and post-lung transplantation. However, the biological basis of this…
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ucsfaging.bsky.social
Our morning concluded with a few more trainee talks and another keynote speaker, Dr. Beth Stevens. #microglial #CNS #inflammation #aging
ucsfaging.bsky.social
Keynote speaker Dr. Vera Gorbunova kicked off the symposium followed by two of our trainees Mariko Foecke and Christoforos Meliadis. #ovary #bone #aging
ucsfaging.bsky.social
Today is a special day! It's our second BARI symposium at the de Young Museum in the beautiful Golden Gate Park.
ucsfaging.bsky.social
Could a reawakening of the silenced X chromosome in females help slow aging-induced cognitive decline? Check out the work by @denadubal.bsky.social along with colleagues Kaitlin Casaletto, Bérénice Benayoun, and Vijay Ramani in Science Advances: bit.ly/3FlN3hj #GeroSky #SciSky
Aging activates escape of the silent X chromosome in the female mouse hippocampus
Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.
www.science.org
ucsfaging.bsky.social
Research from Isha Jain and colleagues published in @cellpress.bsky.social shows that HypoxyStat can prevent or reverse mitochondrial disease in a preclinical mouse model. The study suggests potential transformations in therapeutic strategy for treating other mitochondrial disorders. bit.ly/4kh0csc
HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity
A small molecule that increases oxygen-hemoglobin affinity was shown to prevent and reverse pathology in a mouse model of mitochondrial disease, thereby enabling a practical form of hypoxia therapy.
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ucsfaging.bsky.social
Check out T. Richard Parenteau's work in the Journal of Investigative Dermatology published in December! This study links the age-related increase in epidermis permeability with #inflammaging. Read the article here: bit.ly/4gVs8jg
Epidermal Penetration Increases with Age and May Contribute to Systemic Inflammation
The skin is a major contributor to the age-associated rise in systemic inflammation, known as
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Reposted by Bakar Aging Research Institute
arpa-h.bsky.social
What if we had therapies to extend healthspan and prevent the onset of age-related diseases? PROSPR Program Manager, Andrew Brack, talked with Translating Aging about building a new therapeutic industry focused on maintaining health during aging.
player.captivate.fm/episode/1f42...
Building the Infrastructure for Longevity Medicine: ARPA-H's PROSPR Program (Dr. Andrew Brack, Program Manager)
Quickly and easily listen to Translating Aging for free!
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