Lightnews — Scholar-powered news

Uli Klümper @ulikluemper.bsky.social · 9d

Our first manuscript from the TARGIM project led by Masoud Haghshenasfard:

CFD and OCT-Based Optimisation of Impeller-Induced Shear Stress on Membrane Surfaces in a Circular Test Cell

www.sciencedirect.com/science/arti...

CFD and OCT-Based Optimisation of Impeller-Induced Shear Stress on Membrane Surfaces in a Circular Test Cell

This study investigates the distribution of shear stress in a lab-scale membrane bioreactor consisting of a 56 mm-diameter cylindrical test cell, a 0.…

www.sciencedirect.com

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Uli Klümper @ulikluemper.bsky.social · 17d

In-person participation for the workshop (free of charge) is limited to 40 places and will be allocated on a first-come, first-served basis. To register, send an email to [email protected] indicating your interest in attending.

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Uli Klümper @ulikluemper.bsky.social · 17d

As part of our new EU Project “One Bridge”, led by the University of Patras, we are organizing an 'AMR & #OneHealth Workshop in Dresden, Germany on the 6th of October 2025. The workshop will take place at BUSINESSPARK DRESDEN, Bertolt-Brecht-Allee 22-24, 01309 Dresden from 8:30 – 17:00.

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Uli Klümper @ulikluemper.bsky.social · 17d

🚨WORKSHOP announcement 🚨

“Making environmental #AMR Surveillance Fit for Purpose: Data Integration and the Ecology of Resistance”

6th of October
Dresden, Germany
Free of charge

one-bridge.iwaterfood.gr/workshops/wo...

Register now!

Details below:

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ONE-Bridge project | Conference | Workshops

Fostering collaboration and addressing the interconnected challenges at the interface of human, animal, and environmental health.

one-bridge.iwaterfood.gr

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Uli Klümper @ulikluemper.bsky.social · 17d

Our findings urge a #OneHealth rethink of antibiotic use in aquaculture.

Check the full study led by Jin Huang (Central South University) & Bing Li (Tsinghua Uni Shenzhen Graduate School) here:

www.nature.com/articles/s44...

Microbial risks triggered by oral administration of antibiotics in fish aquaculture persist long after the legally mandated antibiotic withdrawal time - Nature Water

Florfenicol treatment substantially increased the abundance and mobility of antibiotic resistance genes (ARGs) in the common carp gut microbiome. The resistome and mobilome profiles failed to return t...

www.nature.com

Uli Klümper @ulikluemper.bsky.social · 17d

🚨Key message🚨
Regulations based solely on chemical residues overlook microbial risks. Withdrawal times must also consider ARG abundance, mobility, and pathogen enrichment to protect food safety & the environment.

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Uli Klümper @ulikluemper.bsky.social · 17d

Nearly half of the enriched potential pathogens (e.g., Aeromonas, Vibrio, Citrobacter) carried ARGs identical to those on plasmids, showing strong plasmid–chromosome links for resistance spread.

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Uli Klümper @ulikluemper.bsky.social · 17d

Resistance genes weren’t just more abundant, they were also more mobile! Integrons, transposons (carrying floR), and diverse plasmids persisted after withdrawal, keeping ARGs ready for transfer.

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Uli Klümper @ulikluemper.bsky.social · 17d

ARG abundance spiked up to 17× during treatment. It dropped after stopping antibiotics but stayed significantly above control levels even long past the 15-day withdrawal time required for residue compliance.

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Uli Klümper @ulikluemper.bsky.social · 17d

We simulated standard (5 & 10 days) and prolonged (30 & 90 days) florfenicol treatments in common carp and tracked gut microbiota, ARGs, and mobile genetic elements (MGEs) before, during, and after treatment.

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Uli Klümper @ulikluemper.bsky.social · 17d

We reveal that antibiotic resistance #AMR risks in fish farming don’t stop after the legal withdrawal time. Our study shows that oral florfenicol in carp leaves a lasting “resistome” footprint even after fish are deemed market-ready.

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Uli Klümper @ulikluemper.bsky.social · 17d

🐟💊🦠Our new study in @natwater.nature.com 🐟💊🦠

"Microbial risks triggered by oral administration of antibiotics in fish aquaculture persist long after the legally mandated antibiotic withdrawal time"

www.nature.com/articles/s44...

#microsky #amr
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Microbial risks triggered by oral administration of antibiotics in fish aquaculture persist long after the legally mandated antibiotic withdrawal time - Nature Water

Florfenicol treatment substantially increased the abundance and mobility of antibiotic resistance genes (ARGs) in the common carp gut microbiome. The resistome and mobilome profiles failed to return t...

www.nature.com

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Reposted by Uli Klümper

Michael Baym @baym.lol · Sep 1

What was antibiotic resistance like before we ever used antibiotics? How did we change what antibiotic resistance genes looked like over 100 years?

Our paper looking at resistance genes from a century of NCTC historical isolates now out in mGen:
www.microbiologyresearch.org/content/jour...

Genomic resistance in historical clinical isolates increased in frequency and mobility after the age of antibiotics

Antibiotic resistance is frequently observed shortly after the clinical introduction of an antibiotic. Whether and how frequently that resistance occurred before the introduction is harder to determin...

www.microbiologyresearch.org

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Uli Klümper @ulikluemper.bsky.social · 22d

Big thanks to co-authors Peiju Fang, Bing Li, Xia Yu, Dominic Frigon, Kerry Hamilton, Hunter Quon, Thomas Berendonk & Magali de la Cruz Barrón. Also to the Explore-AMR project that allowed me to spend a month at @tsinghuauniversity.bsky.social where this paper's concept and outline were created.
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Uli Klümper @ulikluemper.bsky.social · 22d

We argue that, in addition to quantification, assessing which and what proportion of ARGs can move via MGEs is key for predicting environmental #AMR risks. We outline tools, from ddPCR linkage to hybrid metagenomics, to make this part of routine monitoring and integrate it into QMRA.

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Uli Klümper @ulikluemper.bsky.social · 22d

Excited to share our new Perspective in npj Antimicrobials & Resistance:

"Towards the integration of antibiotic resistance gene mobility into environmental surveillance and risk assessment.”

www.nature.com/articles/s44...

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#AMR #microsky

Towards the integration of antibiotic resistance gene mobility into environmental surveillance and risk assessment - npj Antimicrobials and Resistance

npj Antimicrobials and Resistance - Towards the integration of antibiotic resistance gene mobility into environmental surveillance and risk assessment

www.nature.com

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Uli Klümper @ulikluemper.bsky.social · 28d

First @biorxivpreprint.bsky.social from Eda Deniz Erdem's PhD:

"Selective spread of mobile antibiotic resistance genes in wastewater microbiomes driven by the non-antibiotic pharmaceutical carbamazepine"

www.biorxiv.org/content/10.1...

#AMR #microsky

Selective spread of mobile antibiotic resistance genes in wastewater microbiomes driven by the non-antibiotic pharmaceutical carbamazepine

Carbamazepine (CBZ), a widely used anticonvulsant, is a persistent aquatic micropollutant that withstands biodegradation and accumulates in wastewater-impacted environments. While non-antibiotic pharm...

www.biorxiv.org

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