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Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · 1h

Congratulations to CMR PhD student, John Nguyen, on receiving a @aegeanconf.bsky.social Trainee Award at the 6th International Conference on Stem Cells, in Sissi, Crete, Greece.
#muscle #Myotwitter #stemcells #regeneration #metabolism #physiology

Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · 16d

Congratulations to John Nguyen on a successful PhD oration: ‘Metabolic control of skeletal muscle regeneration’. Now for the thesis!
Supervisors: Prof Gordon Lynch, @kristyswid.bsky.social, Assoc Prof Kristin Brown, @craigagoodman1.bsky.social
#muscle #stemcells #regeneration #injury #metabolism

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Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · 24d

The CMR gathers wearing green to celebrate International Myotonic Dystrophy Awareness Day to promote research & funding to improve the lives of those affected by DM, a neuromuscular disease causing progressive muscle weakness
@mda.org @myotonicstrong.bsky.social #muscle

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Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · Sep 7

The CMR is on a mission to understand and treat DMD and other neuromuscular disorders. We remain deeply committed to, and passionately support, #WDAD2025
#muscle #Duchenne #dystrophy #muscular

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Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · Aug 30

‪
Congrats to Steffen Raun, Lykke Sylow and Team for their new Redox Biology paper, "Skeletal muscle Rac1 mediates exercise training adaptations towards muscle glycogen resynthesis and protein synthesis", that included the CMR's Prof Paul Gregorevic
www.sciencedirect.com/science/arti...

Skeletal muscle Rac1 mediates exercise training adaptations towards muscle glycogen resynthesis and protein synthesis

Long-term exercise training elicits tremendous health benefits; however, the molecular understanding is incomplete and identifying therapeutic targets…

www.sciencedirect.com

Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · Aug 21

Congrats to Sebastian BassStringer, Prof Juli McMullen & Team for their new paper "Generation and evaluation of a novel PI3K-targeting gene therapy in the failing mouse heart and healthy sheep heart", that included the CMR's Prof Paul Gregorevic
www.sciencedirect.com/science/arti...

Generation and evaluation of a novel PI3K-targeting gene therapy in the failing mouse heart and healthy sheep heart

Heart failure (HF) remains a clinical challenge with cardiac dysfunction typically progressing even with treatment, and heart transplants only availab…

www.sciencedirect.com

Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · Aug 7

Congratulations to Kevin (Yansong) Lu & Prof Pete Currie of the Australian Regenerative Medicine Institute (ARMI), and the CMR's Dr Avnika Ruparelia, for their new review paper, "Zebrafish: Lessons and Insights into Skeletal Muscle Research"

cshperspectives.cshlp.org/content/earl...

Zebrafish: Lessons and Insights into Skeletal Muscle Research

A new type of review journal, featuring comprehensive collections of expert review articles on important topics in the molecular life sciences

cshperspectives.cshlp.org

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Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · Jul 31

Check out the new post-doc opportunity in the Lab of Prof Matt Watt, in collaboration with an industry partner, on muscle signalling and metabolism related to metabolic disease and future obesity treatments
unimelb.wd105.myworkdayjobs.com/UoM_External...

Research Fellow in Muscle Signalling and Metabolism

Role type: Full time, fixed term position for 24 months Faculty: Medicine, Dentistry and Health Sciences Department/School: Anatomy and Physiology Salary: Level A – $108,156 - $116,094 p.a. plus 17% s...

unimelb.wd105.myworkdayjobs.com

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Reposted by Centre for Muscle Research (CMR)

Craig A. Goodman @craigagoodman1.bsky.social · Jul 28

It's time to register for the 2025 Victorian Muscle Network Symposium! 🚨
Please register now: victorianmusclenetwork.wordpress.com
🗓️Make sure to register by the 14th of September
👀 Keynote speakers to be confirmed soon

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Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · Jul 15

Congrats to Bryan Remaily, Chris Coss, Mitch Phelps, and Team, for their new JCSM Commications paper "Intramuscular CMT-167 Tumours Produce a Mild Cachexia Phenotype in C57BL/6J Mice", that included the CMR's Prof Paul Gregorevic

onlinelibrary.wiley.com/doi/10.1002/...

Intramuscular CMT‐167 Tumours Produce a Mild Cachexia Phenotype in C57BL/6J Mice

Background Cancer cachexia is a debilitating syndrome characterized by irreversible losses in skeletal muscle mass, with or without losses in adipose tissue. Cancer cachexia is an underrecognized sy...

onlinelibrary.wiley.com

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Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · Jul 4

The CMR recognises #WorldSarcopeniaDay.
Interrogating ways to preserve muscle function as we age is a major theme of study in the CMR & our researchers continue to make contributions to the field.
#Myotwitter #sarcopenia #aging #longevity #health #exercise

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Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · Jul 3

Checkout the new review paper from the CMR's Julian Wong, Yaan-Kit Ng, Ronnie Blazev & @benparkerlab.bsky.social & the NNF CBMR's Jeppe Kjærgaard & @adeshmukh.bsky.social on Skeletal Muscle Proteomics: Considerations and Opportunities.
www.nature.com/articles/s44...

Skeletal muscle proteomics: considerations and opportunities - npj Metabolic Health and Disease

npj Metabolic Health and Disease - Skeletal muscle proteomics: considerations and opportunities

www.nature.com

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Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · Jul 2

Congratulations to Amy Bongetti, Dr Marissa Caldow, Dr Yasmine Ali Abdelhamid and Prof Gordon Lynch for their new review paper, "Evaluating skeletal muscle wasting and weakness in models of critical illness".
#muscle #ICU
portlandpress.com/clinsci/arti...

Evaluating skeletal muscle wasting and weakness in models of critical illness

Skeletal muscle wasting and weakness are common complications associated with admission to the intensive care unit (ICU), with the loss of muscle mass and function increasing mortality and contributin...

portlandpress.com

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Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · Jun 20

Congratulations to Lee-Anne Chapple,the CMR's Gordon Lynch and Olav Rooyackers for their new review on "Impaired muscle metabolism in the ICU: interrogating the underlying pathophysiology".

journals.lww.com/co-criticalc...

Impaired muscle metabolism in the ICU: interrogating the... : Current Opinion in Critical Care

lled trials in critically ill adults have reported signals of harm from higher protein administration compared to lower protein doses or standard of care, with significant results pertaining to reduce...

journals.lww.com

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Reposted by Centre for Muscle Research (CMR)

Australian Physiological Society @aups-physiology.bsky.social · Mar 25

A place for physiologist of Australia to connect, share, and promote each other’s work in cutting-edge research and education. Follow us to stay updated on the latest in physiology, events, and opportunities!
🔗 Tag your colleagues, share your research, and let’s grow this community together!

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Reposted by Centre for Muscle Research (CMR)

Craig A. Goodman @craigagoodman1.bsky.social · Jun 11

The Australian Physiological Society (AuPS) is now on BlueSky:
‪@aups-physiology.bsky.social‬

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Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · Jun 10

Congrats to Dr Dean Campelj, Prof Emma Rybalka & Team for their new JCSM paper "Haptoglobin & Glutamine Synthetase May Biomark Cachexia Induced by Antiacute Myeloid Leukaemia Chemotherapy" that also involved the CMR's @craigagoodman1.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...

Haptoglobin and Glutamine Synthetase May Biomark Cachexia Induced by Antiacute Myeloid Leukaemia Chemotherapy

Background Anticancer chemotherapy is an underappreciated contributor to cancer cachexia, an often-irreversible body-wasting condition that causes 20%–30% of cancer-related deaths. An obstacle to pr...

onlinelibrary.wiley.com

Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · Jun 5

Victorian Muscle Network (VMN)
✨SAVE THE DATE!✨
Please join us for the 8th Victorian Muscle Network Symposium to be held on Friday the 14th of November at Monash Caulfield Campus.
Keep an eye out for updates on keynote speakers and registrations👀
Looking forward to seeing you all there in 2025 🥳

Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · Jun 4

Well done Chris Karagiannis for delivering an outstanding PhD oration! The CMR and his supervisors, Prof Paul Gregorevic, @craigagoodman1.bsky.social & Dr Rachel Thomson, are proud. Now for the thesis.
#cancer #cachexia #muscle

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Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · May 24

Congrats Amy Bongetti on your PhD thesis submission!
Flanked by proud supervisors, Dr Marissa Caldow, Dr Yasmine Ali Abdelhamid , Prof Gordon Lynch
#muscle #ICU #physiology

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Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · May 15

Check out the News and Views in @natmetabolism.nature.com by Sue Bodine & the CMR's @craigagoodman1.bsky.social on a new study from Troy Hornberger's lab on mechanically-sensitive MKK3b/6, p38, MK2, mTORC1 signaling mediating resistance exercise-induced muscle growth www.nature.com/articles/s42...

Mechanically sensitive MAPK signalling mediates resistance exercise-induced muscle growth - Nature Metabolism

Understanding the molecular regulators of skeletal muscle mass is essential for the future development of therapies that promote muscle growth and/or inhibit muscle wasting. A new study shows that mus...

www.nature.com

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Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · May 10

Congrats to Ronnie Blazev, @benparkerlab.bsky.social and Team for their new paper, "Site-specific quantification of the in vivo UFMylome reveals myosin modification in ALS", that also involved CMR members Yann-Kit Ng, @craigagoodman1.bsky.social & Paul Gregorevic
#ALS
www.cell.com/cell-reports...

Site-specific quantification of the in vivo UFMylome reveals myosin modification in ALS

UFMylation is the post-translational modification of Ubiquitin Fold Modifier1 (UFM1) applied to substrate proteins. Blazev et al. develop an antibody-based enrichment approach followed by LC-MS/MS to ...

www.cell.com

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Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · May 2

Congrats to Maddy Meli & Brett Comer for their paper, "Ngn2-Induced Differentiation of the NG108-15 Cell Line Enhances Motor Neuronal Differentiation and Neuromuscular Junction Formation", also involving the CMR's @kristyswid.bsky.social Marissa Caldow & Gordon Lynch
www.mdpi.com/2218-273X/15...

www.mdpi.com

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Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · May 1

Congrats to Jeremy Lum, Justin Yerbury and Team for their new paper, "A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosis', that also involved the CMR's A/P Peter Crouch
#ALS
www.thelancet.com/journals/ebi...

A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosis

These findings support CET polytherapy as an advantageous alternative compared to CuATSM monotherapy and highlight the potential of utilising small molecules targeting SOD1 as a polytherapy avenue for...

www.thelancet.com

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Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · Apr 6

Congrats to Amr Abdeen, the CMR's A/P Peter Crouch, Kay Double, & Team, for their new paper, "Parkinson-like wild-type superoxide dismutase 1 pathology induces nigral dopamine neuron degeneration in a novel murine model"
#parkinson's
link.springer.com/article/10.1...

Parkinson-like wild-type superoxide dismutase 1 pathology induces nigral dopamine neuron degeneration in a novel murine model - Acta Neuropathologica

Atypical wild-type superoxide dismutase 1 (SOD1) protein misfolding and deposition occurs specifically within the degenerating substantia nigra pars compacta (SNc) in Parkinson disease. Mechanisms dri...

link.springer.com

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