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Uri Alon @urialonlab.bsky.social · May 25

Apple podcasts: podcasts.apple.com/us/podcast/%...
Spotify: open.spotify.com/show/78Ubzk0...

Podcast · אור דניאל | Learntech.co.il · רעב לידע פודקסט בו אור דניאל מביא נגיסי ידע בעולמות הלמידה, הטכנולוגיה והיזמות. לומדים מארכיטקט למידה שעשה קריירה מללמוד. הצטרפו לחוויה שלא רק תעשיר את חייכם, א...

open.spotify.com

Uri Alon @urialonlab.bsky.social · May 25

Why does innovative research necessitate a jump into the unknown? Find out (and much more) in episode 147 of רעב לידע עם אור דניאל (Hungry for Knowledge with Or Daniel)!
www.learntech.co.il/podcast/pod1...

מדוע מדע חדשני דורש קפיצה אל הלא נודע? | פרופ' אורי אלון | פרק 147 · LearnTech

הכירו את פרופ' אורי אלון, מנהל מעבדת סגול לאריכות ימים במכון ויצמן. בפרק מרתק זה תגלו מדוע תסכול וכישלון הם לא רק חלק מהמחקר אלא המפתח לגילויים פורצי דרך, איך "ענן המחקר" יכול להפוך מאויב למדריך, ומה ...

www.learntech.co.il

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Uri Alon @urialonlab.bsky.social · Apr 23

It struck me that I spent 25 years building and nurturing this group, longer than my marriage or children, which has great power and meaning. (2/2)

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Uri Alon @urialonlab.bsky.social · Apr 23

Sweet moment in life, our 25th lab anniversary. In a circle, we looked at each other, a group of people with shared values and a soft approach, who want each other to succeed and be happy. (1/2)

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Uri Alon @urialonlab.bsky.social · Apr 16

Masterpiece by a masterful scientist
Natural Neuroscience by Nachum Ulanovsky
@mitpress.bsky.social mitpress.mit.edu/978026204499...

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Uri Alon @urialonlab.bsky.social · Apr 11

Our latest on aging, where we reveal an unexpected link between healthspan and equality of lifespans.
By @y1fanyang.bsky.social , out now @naturecomms.bsky.social
www.nature.com/articles/s41...

Compression of morbidity by interventions that steepen the survival curve - Nature Communications

Longevity research aims to extend lifespan and reduce sickspan in aging. Here, the authors show that only interventions that steepen survival curves can compress the sickspan relative to lifespan.

www.nature.com

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Uri Alon @urialonlab.bsky.social · Mar 31

Now in French and Spanish - our pregnancy paper is highlighted also in @lefigaro.fr and @elpais.com

sante.lefigaro.fr/medecine/com...

elpais.com/salud-y-bien...

Comment la grossesse chamboule le corps de la future mère, et pourquoi elle ne redevient jamais vraiment elle-même

Une étude menée sur plus de 300 000 femmes révèle les bouleversements visibles dans le sang et l’urine des femmes enceintes. Des résultats qui pourraient aider à mieux prédire les complications de la ...

sante.lefigaro.fr

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Reposted by Uri Alon

Carlos Caldas 🇵🇹🇮🇱🇪🇺🇬🇧🎗 @carloscaldas1960.bsky.social · Mar 30

Amazing clinical epidemiology! The power of numbers! @urialonlab.bsky.social

www.nature.com/articles/d41...

Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet

Data from 300,000 births reveal how essential biological measurements are altered by carrying and delivering a baby.

www.nature.com

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Reposted by Uri Alon

Carissa Wong @carissacwwong.bsky.social · Mar 28

We now have our most detailed picture yet of how pregnancy affects the body on a weekly basis from 20 weeks pre-conception to 1.5 years after delivery. Fab work from @urialonlab.bsky.social

Read @newscientist.com.

www.newscientist.com/article/2473...

Pregnancy’s lasting effects on different parts of the body revealed

An "unprecedented view" of how the body changes during and after pregnancy has revealed many long-lasting impacts on the liver, kidneys and more

www.newscientist.com

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Uri Alon @urialonlab.bsky.social · Mar 30

"Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet"
Our study highlighted in @nature.com News

www.nature.com/articles/d41...

Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet

Data from 300,000 births reveal how essential biological measurements are altered by carrying and delivering a baby.

www.nature.com

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Uri Alon @urialonlab.bsky.social · Mar 27

Work by Dr. Alon bar, Ron Moran. With Netta Mendelson Cohen, Avi Mayo, Yael Korem-Kohanim, Yoel Toledano, Clalit Healthcare.
Read the complete story here:
www.science.org/doi/10.1126/...

Pregnancy and postpartum dynamics revealed by millions of lab tests

Analysis of 300,000 pregnancies shows detailed physiological changes at weekly resolution in health and complications.

www.science.org

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Uri Alon @urialonlab.bsky.social · Mar 27

Pregnancy is a dynamic process, stretching physiological control to the extreme with lasting postpartum effects.
We now have a deeper understanding of physiological adaptation.

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Uri Alon @urialonlab.bsky.social · Mar 27

In pregnancies with complications (pre-eclampsia, gestational diabetes, postpartum hemorrhage),
distinct deviations from healthy profiles were evident. Gestational diabetes, in particular, showed marked changes, mostly in the pre-conception period.

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Uri Alon @urialonlab.bsky.social · Mar 27

The study also spans 20 weeks pre-conception, where we see changes in folic acid, CRP, and albumin levels.
These hint lifestyle changes such as a healthier diet and taking recommended supplements, supporting healthy fetal development.

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Uri Alon @urialonlab.bsky.social · Mar 27

Nearly half of the lab tests take many months (and in some cases up to a year) to settle after delivery,
highlighting what a journey pregnancy is, even after delivery.

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Uri Alon @urialonlab.bsky.social · Mar 27

Lab tests can be clustered into stereotypical profiles, implying global control principles governing physiological adaptations in pregnancy.
We see strong undershoots and overshoots in many lab tests at delivery, indicating strong compensation mechanisms in action during pregnancy.

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Uri Alon @urialonlab.bsky.social · Mar 27

Excited to share our new study revealing the intricate dynamics of pregnancy & postpartum physiology! We analyzed 40M lab tests from 300K pregnancies and 160K women (cross-sectional) and mapped week-by-week changes starting from preconception to months-long postpartum recovery.

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Reposted by Uri Alon

Waggoner Lab @labwaggoner.bsky.social · Mar 27

Harnessing huge data from pregnancy natural experiments @urialonlab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

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Uri Alon @urialonlab.bsky.social · Mar 24

Theory predicted two kinds of fibrosis, hot and cold.
We show in vivo that hot and cold fibrosis describe heart failure, and heart attack, respectively, showing that they are very different disease states. @shovalmiyara.bsky.social @eldadtzahor.bsky.social

Shoval Miyara @shovalmiyara.bsky.social · Mar 20

Our work made it to the cover of @cp-cellsystems.bsky.social ! 🥳

Cold and hot fibrosis define clinically distinct cardiac pathologies

www.cell.com/cell-systems...

Special thanks to Danielle Kimchi for creating this beautiful cover! 🎉

@urialonlab.bsky.social @eldadtzahor.bsky.social

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Uri Alon @urialonlab.bsky.social · Mar 18

Sagol lecture in longevity research - Myriam Grunewald on vasculature maintenance for longevity

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Uri Alon @urialonlab.bsky.social · Feb 24

Join us at the ICSB in Dublin this October - I will chair the session on aging systems biology
icsb2025.com

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Reposted by Uri Alon

Shoval Miyara @shovalmiyara.bsky.social · Feb 19

It’s finally here! My PhD work, five years in the making, is now published @CellSystems @cellpress.bsky.social 🚨
Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...

Cold and hot fibrosis define clinically distinct cardiac pathologies

Miyara et al. identify two types of fibrosis in cardiac pathologies: “hot fibrosis,” involving macrophage-myofibroblast interactions in chronic injuries, and acute-injury-driven “cold fibrosis,” contr...

www.cell.com

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Uri Alon @urialonlab.bsky.social · Feb 10

My brilliant PhD student @Yaelebel.bsky.social gave a talk at the Azrieli Graduate Students forum about her research on using excitable dynamics to explain pulsatile immune phenomena, and how research questions can come from the most unexpected places. Well done Yael!
youtu.be/MdwqWx5emo4

Yael Lebel

YouTube video by Azrieli Fellows Program

youtu.be

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Uri Alon @urialonlab.bsky.social · Feb 9

Will be attending the Quantitative Immunology workshop at the Princeton Center for Theoretical Science later month.

pcts.princeton.edu/events/2025/...

Quantitative Immunology

Organizers: Andrea Graham; Julia Merkenschlager; Alexander Ploss; Colin Scheibner; Ned WingreenThe immune system functions across diverse scales, from the recognition of molecules to the evolution of ...

pcts.princeton.edu

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Uri Alon @urialonlab.bsky.social · Feb 4

and found that only targeting CRH can bypass this adaptation and effectively lower cortisol. (2/2)

Work by @tomermilo.bsky.social

www.embopress.org/doi/full/10....

Hormone circuit explains why most HPA drugs fail for mood disorders and predicts the few that work | Molecular Systems Biology

imageimageA mathematical model suggests that existing HPA-targeting drugs failed in clinical trials for mood disorders because the endocrine glands change their functional mass. The model predicts CRH...

www.embopress.org

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