Lightnews — Scholar-powered news

The Vallee Foundation @valleefoundation.bsky.social · 1d

Vallee Scholar Lisa Giocomo reveals how aging affects special memory news.ssbcrack.com/study-reveal...

Study Reveals How Aging Affects Spatial Memory in Mice - SSBCrack News

In a groundbreaking study, researchers at Stanford Medicine have discovered critical insights into how spatial memory declines with aging, revealing potential

news.ssbcrack.com

The Vallee Foundation @valleefoundation.bsky.social · 1d

Vallee Scholar Daniel Jarosz becomes first senior associate dean for basic science at Stanford University. med.stanford.edu/news/all-new...

Dan Jarosz becomes first senior associate dean for basic science

Jarosz is the inaugural appointment to the newly created position, which will support basic science faculty throughout the Stanford School of Medicine.

med.stanford.edu

The Vallee Foundation @valleefoundation.bsky.social · 1d

Vallee Scholar Madeline Lancaster appointed Joint Head of the Cell Biology Division at MRC Laboratory of Molecular Biology in Cambridge:
www2.mrc-lmb.cam.ac.uk/madeline-lan...

Madeline Lancaster appointed Joint Head of the Cell Biology Division - MRC Laboratory of Molecular Biology

Group Leader Madeline Lancaster joins Manu Hegde to oversee the LMB’s Cell Biology Division.

www2.mrc-lmb.cam.ac.uk

The Vallee Foundation @valleefoundation.bsky.social · 1d

Vallee scholar Rickard Sandberg, professor of Molecular Genetics, member of the Nobel Committee, is interviewed by Sharon Jåma about this year's Nobel prize.
www.youtube.com/watch?v=5fxn...

“A fundamental discovery about the principle that keeps our immune system in check” | Medicine prize

YouTube video by Nobel Prize

www.youtube.com

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The Vallee Foundation @valleefoundation.bsky.social · Jul 3

Vallee Scholar Weizhe Hong has a new paper out in Nature which shows a remarkable convergence of neuroscience and artificial intelligence: www.eurekalert.org/news-release...

First-of-its-kind study finds striking parallels between biological and artificial intelligence during social interaction

A first-of-its-kind study reveals that when mice interact socially, specific brain cell types synchronize in "shared neural spaces," and AI agents develop analogous patterns when engagi...

www.eurekalert.org

The Vallee Foundation @valleefoundation.bsky.social · Jun 19

Vallee Scholar Bob Datta is on Instagram with an important message about Alzheimer's research
www.instagram.com/reel/DKzuKjR...

The Vallee Foundation @valleefoundation.bsky.social · Jun 9

Congratulations to Vallee Fdtn Director Wade Harper (HMS) on $5M+ Fox Fdtn grant for PD research & collab with VVPs Brenda Schulman, Ulrich Hartl (MPI), Judith Frydman (Stanford) among others in international, multidisciplinary Collaborative Research Network (CRN)
hms.harvard.edu/departments/...

hms.harvard.edu

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The Vallee Foundation @valleefoundation.bsky.social · Jun 5

Many congratulations to Vallee Scholar Tanmay Bharat, Group Leader in the MRC Lab of Molecular Biology, who has been awarded the EMBO Gold Medal for his research in the field of structural microbiology! www2.mrc-lmb.cam.ac.uk/tanmay-bhara...

Tanmay Bharat awarded EMBO Gold Medal - MRC Laboratory of Molecular Biology

Tanmay Bharat, Group Leader in the LMB’s Structural Studies Division, received EMBO’s Gold Medal in recognition of his work on prokaryotic surface molecules.

www2.mrc-lmb.cam.ac.uk

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The Vallee Foundation @valleefoundation.bsky.social · May 28

Congratulations to Dr Danelle Devenport (Vallee Scholar 2014), Shirley M. Tilghman Professor of Molecular Biology at Princeton U, who received the President's Award for Distinguished Teaching at Commencement ceremonies on Tuesday, May 27

www.princeton.edu/news/2025/05...

Faculty members receive President’s Awards for Distinguished Teaching

Professors Rebecca Carey, Gabriel Crouch, Danelle Devenport and Nathaniel Fisch received the President’s Award for Distinguished Teaching at Commencement ceremonies May 27.

www.princeton.edu

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The Vallee Foundation @valleefoundation.bsky.social · May 28

So happy for our Vallee Visiting Professor Wolfang Baumeister who has just been named the Shaw Prize in Life Science and Medicine: erc.europa.eu/news-events/...

ERC grantee wins the Shaw Prize in Life Science and Medicine

2025 Shaw Prize honours ERC-funded research in molecular imaging

erc.europa.eu

The Vallee Foundation @valleefoundation.bsky.social · May 16

Research teams working with Tyler Jacks (VVP 2016) (MIT) and William Freed-Pastor (Dana-Farber and MIT) have a new article in Science in which they show how a class of proteins expressed in pancreatic cancer cells, could serve as targets for immune cell therapy.
www.science.org/doi/10.1126/...

Pancreatic cancer–restricted cryptic antigens are targets for T cell recognition

Translation of the noncoding genome in cancer can generate cryptic (noncanonical) peptides capable of presentation by human leukocyte antigen class I (HLA-I); however, the cancer specificity and immun...

www.science.org

The Vallee Foundation @valleefoundation.bsky.social · May 16

Feng Zhang (Vallee Scholar 2013) and his team at the McGovern and Broad Institutes have reengineered a compact RNA-guided enzyme they found in bacteria into an efficient, programmable editor of human DNA. See their paper in Nature Biotch
www.nature.com/articles/s41...

Evolution-guided protein design of IscB for persistent epigenome editing in vivo - Nature Biotechnology

A combination of engineering approaches is used to improve the function of IscB for a variety of editing activities in vivo.

www.nature.com

The Vallee Foundation @valleefoundation.bsky.social · May 16

Elena Conti, PhD (Vallee Visiting Prof 2019), Director, MPI of Biochemistry in Martinsried, shares this year’s prestigious Jung Prize for Medicine with Jorn Piel, MD, ETH Zurich.
thevalleefoundation.org/news/elena-c...

Elena Conti wins Jung Prize for Medicine | The Vallee Foundation

thevalleefoundation.org

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The Vallee Foundation @valleefoundation.bsky.social · May 13

Congratulations to Feng Zhang (Vallee Scholar 2013) (Broad Inst, MIT, HHMI Investigator) who received an honorary doctorate from Duke University on Sunday!

today.duke.edu/2025/04/duke...

Duke to Award Three Honorary Degrees at 2025 Commencement Ceremony | Duke Today

today.duke.edu

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The Vallee Foundation @valleefoundation.bsky.social · Apr 28

Chris Mason (Vallee Scholar 2014) at Weil Cornell Medicine is one of the PIs seeking to catalog the normal human virome, the immense ecosystem of viruses that lives in and on us.
news.weill.cornell.edu/news/2025/04...

A VAST New View of Viruses

A major new effort at Weill Cornell Medicine seeks to catalog the normal human virome, the immense ecosystem of viruses that lives in and on us.

news.weill.cornell.edu

The Vallee Foundation @valleefoundation.bsky.social · Apr 17

Vallee Scholar (2021) Ricardo Mallarino (Princeton) has been using the sugar glider (Petaurus breviceps) to investigate immunological defense strategies. Check out his recent paper in Science
www.science.org/doi/10.1126/....

Cathelicidin antimicrobial peptides mediate immune protection in marsupial neonates

Cathelicidin antimicrobial peptides protect marsupial neonates by mediating immune defense against pathogens.

www.science.org

Reposted by The Vallee Foundation

Dan Landau @landau.bsky.social · Apr 11

Excited to share our exploration @naturemethods.bsky.social into new horizons opening up in the era of low cost sequencing!

🔥 Deeper sequencing at WGS scale for PPM sensitivity of tumor informed MRD
🔥Duplex sequencing at WGS scale for plasma only exploration of ctDNA

Check out thread 👇

Alex @alexpellancheng.bsky.social · Apr 11

What happens when sequencing costs go ⏬ ?
Imagination and new opportunities go ⏫
@landau.bsky.social

Let's look at what you can do when you perform deep WGS on cfDNA for cancer detection. Our recent work with the
@UltimaGenomics
platform 🧵👇
Lets goooo!!
rdcu.be/ehkUb

Error-corrected flow-based sequencing at whole-genome scale and its application to circulating cell-free DNA profiling

Nature Methods - This work integrates duplex sequencing with cost-effective Ultima sequencing to enhance the accuracy of whole-genome circulating cell-free DNA profiling.

rdcu.be

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Reposted by The Vallee Foundation

Pontus Skoglund @pontus-skoglund.bsky.social · Apr 14

Join us at the Royal Society in London 14 November for a day on Ancient genomes, human biology and medicine!

Many slots are reserved for talks from submitted abstracts related to the topic, alongside speakers Svante Pääbo, Priya Moorjani, @mathiesoniain.bsky.social and Lluis Quintana-Murci.

Genetics Society UK @gensocuk.bsky.social · Apr 14

Registration now open! Join us for our Autumn Meeting:
“Ancient genomes: perspectives on human biology and medicine” organised by @janetk.bsky.social and @pontus-skoglund.bsky.social.

Explore how ancient DNA informs migration, adaptation & disease.

genetics.org.uk/events/ancie...

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Reposted by The Vallee Foundation

Roux Lab, Geneva @rouxlab.bsky.social · Apr 14

Abstract submissions for short talks are still opened until April 20th for the EMBO Escrt meeting 2025. There are plenty of options for short talks, please apply online at meetings.embo.org/event/25-escrt

ESCRT function, evolutionary diversity and mechanism of action

The ESCRTs (Endosomal Sorting Complexes Required for Transport) were discovered in 2002 and became one of the most dynamic fields of research in membrane cell biology. ESCRTs are protein complexes fo…

meetings.embo.org

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The Vallee Foundation @valleefoundation.bsky.social · Apr 11

Tanmay Bharat (Vallee Scholar 2018) has been working with colleagues at Brandeis University and the Max Planck Institute for Biology, Tubingen, on The Role of Mechanical Forces in Multicellularity:

When the pressure is on, Archaea go multicellular

Mechanical compression induces multicellular organization in archaea

www.mpg.de

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The Vallee Foundation @valleefoundation.bsky.social · Apr 11

New paper from Vallee Scholar (2018) Sichen (Susan) Shao in Science: www.science.org/doi/10.1126/...

ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution

ARMC1 partitions between distinct outer mitochondrial membrane complexes and the cytosol to control mitochondrial distribution.

www.science.org

The Vallee Foundation @valleefoundation.bsky.social · Mar 24

Check out Danelle Devenport's latest paper in Science. Danelle, Shirley Tighten Professor of Molecular Biology at Princeton, was a 2014 Vallee Scholar.
www.science.org/doi/10.1126/...

Epithelial polarization by the planar cell polarity complex is exclusively non–cell autonomous

For cells to polarize collectively along a tissue plane, asymmetrically localized planar cell polarity (PCP) complexes must form intercellular contacts between neighboring cells. Yet, it is unknown wh...

www.science.org

The Vallee Foundation @valleefoundation.bsky.social · Mar 21

And more from Rickard Sandberg (Vallee Scholar 2015) at the Karolinska
www.researchgate.net/publication/...

Effect of Layer Thickness and Particle Size Distribution on the Microstructure and Properties of Ti6Al4V Processed by Laser Powder Bed Fusion | Request PDF

Request PDF | Effect of Layer Thickness and Particle Size Distribution on the Microstructure and Properties of Ti6Al4V Processed by Laser Powder Bed Fusion | The technological advancements in laser po...

www.researchgate.net

The Vallee Foundation @valleefoundation.bsky.social · Mar 21

New paper from Vallee Scholar Viviana Gradinaru

www.nature.com/articles/s41...

Spatial genomics of AAV vectors reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo - Nature Biotechnology

Profiling transcriptional crosstalk between promoters and cell-type-specific enhancers allows large gene cargo delivery.

www.nature.com

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Reposted by The Vallee Foundation

Harvard Med Cell Biology @harvardcellbio.bsky.social · Mar 17

Exciting new work from the Shao lab @sshaolab.bsky.social by @samanthasedor.bsky.social reveals novel functions and interactions for the CDAN1 protein with ASF1A/B complexes. www.nature.com/articles/s41...

Mechanism of ASF1 engagement by CDAN1

Nature Communications - CDAN1 is an essential protein with unclear function that binds the histone chaperone ASF1. Here, the authors reveal that CDAN1 sequesters multiple copies of ASF1 by engaging...

www.nature.com

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