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Reposted by Roux Lab, Geneva

Juanma García-Arcos @juanmagararc.bsky.social · 3d

*ALL*source data and Python notebooks are available (you can reproduce all figures!)
🔗 doi.org/10.6084/m9.f...
We hope this helps make lifetime analysis transparent and comparable across setups.
📄 www.biorxiv.org/content/10.1...

@rouxlab.bsky.social
#FLIM #FlipperTR #Microscopy #OpenScience

Data and codes

Data and codes corresponding to the preprint:

doi.org

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Juanma García-Arcos @juanmagararc.bsky.social · 3d

🚨 New preprint out!
“Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM” with Tithi Mandal and @rouxlab.bsky.social
We benchmark and describe step-by-step Flipper-TR FLIM measurements across different set-ups and and strategies.

www.biorxiv.org/content/10.1...

Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM

Flipper-TR is a membrane dye sensitive to lipid packing widely used to probe membrane tension in live cells via fluorescence lifetime imaging microscopy (FLIM). However, no consensus currently exists ...

www.biorxiv.org

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Holthuis Lab @holthuislab.bsky.social · 8d

I am pleased to 📣 today’s superb thesis defense by Christian Schroer on “Chemical strategies for studying lipid signaling and transport”. Part of his work was recently published in the JLR; the other part will follow soon. A very proud and somewhat tipsy “Doktorvater” 🥂

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Markku Hakala @mhakala.bsky.social · 9d

Undergraduate/internship/master's thesis position: jobs.helsinki.fi/job-invite/4...

Research Assistant or Master Thesis worker, group Hakala

jobs.helsinki.fi

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Markku Hakala @mhakala.bsky.social · 9d

PhD student position: jobs.helsinki.fi/job-invite/4...

Doctoral Researcher, group Hakala

jobs.helsinki.fi

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Markku Hakala @mhakala.bsky.social · 9d

I have a PhD student and an undergrad student positions open at the Institute of Biotechnology @helsinki.fi We are using reconstitution, cell and structural biology to study protein-membrane interactions and membrane microdomain formation. Links to calls below! Feel free to drop a message and share!

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De Camilli Lab @pdc-lab.bsky.social · 9d

"Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C" out now in PLOS Biology
journals.plos.org/plosbiology/...

Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C

VPS13A and VPS13C are bridge-like lipid transport proteins with distinct subcellular localization and function, and their absence is linked with chorea-acanthocytosis and Parkinson's disease, respecti...

journals.plos.org

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Mechanobiology Institute @mbisg.bsky.social · 28d

Order matters! Aurelien Roux @rouxlab.bsky.social studied the formation of multi-cellular tornado-like structures and regeneration of heads in hydra to share with us how stress fields, topology and geometry of initial tissue organization set the sequence of morphogenesis. #MBIMPG2025

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Erdinc Sezgin @sciezgin.bsky.social · Sep 8

Previous preprint is now published in RSC Chemical Biology.
If you are interested in plasma membrane labeling, see the paper! 👇
pubs.rsc.org/en/content/a...

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Roux Lab, Geneva @rouxlab.bsky.social · Jul 10

Nice discussions after the talk given online yesterday at cytophys.org, presenting the work of @pauguillamat.bsky.social @clairedessalles.bsky.social @yamini-ravichan.bsky.social @oriolmb.bsky.social and Tithi Mandal. Available on the lab youtube channel at:
youtu.be/g-7HomnPdtk

Cell forces, order and flows during In vitro reconstitution of morphogenesis

YouTube video by Roux Lab - University of Geneva

youtu.be

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Manuel Thery @manuelthery.bsky.social · Jul 8

Ever wished to become an actin star? 😎
Then try getting suspended above a non-adhesive substrate.
www.nature.com/articles/s41...

A multicellular star-shaped actin network underpins epithelial organization and connectivity - Nature Communications

The combined role of cellular junctions and actomyosin networks in tissues remains unclear. Here, the authors identify a tissue-scale star-shaped network of actomyosin that preserves cell shape, limit...

www.nature.com

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Marko Kaksonen @kaksonen.bsky.social · Jul 7

Hello microscopy and imaging experts and enthusiasts!
We are looking for a staff scientist to join us here in Geneva to work on microscopy and image analysis projects! See the link for the job announcement (in French and in English).

Please apply and/or repost!

jobs.unige.ch/www/wd_porta...

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Ben Engel @cellarchlab.com · Jun 27

The @embo.org ESCRT meeting was packed with membrane remodeling from every branch of the tree of life🌳. Some awesome science 🧪 highlights in the next posts 🧵. But a first impression… the venue!! Wow, Caux castle up a cogwheel train, overlooking Lac Léman! Perfect! 🌄 Thank you @rouxlab.bsky.social 🤗

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Juan Martin Serrano @juanmartin-serrano.bsky.social · Jun 27

What a fantastic ESCRT meeting, the field is going strong and full of exciting science. Many thanks to @rouxlab.bsky.social @cellarchlab.com @jujumathieu.bsky.social @magromayor.bsky.social @majarad.bsky.social for organising such a a great event

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Angélique Perret @angieprrt.bsky.social · Jun 17

🤩 Last week I successfully defended my PhD!
It was such a special day, made even better by having friends, family, and colleagues there with me. Thanks for all the support and kind words!
Huge thanks to my jury members for the thoughtful feedback and conversations.

@soldatilab.bsky.social

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Yamini Ravichandran @yamini-ravichan.bsky.social · Jun 4

Thank you for this opportunity @the-node.bsky.social to let me share the behind the story of my postdoc article from the @rouxlab.bsky.social here’s to squishing jellies!!

Squishing jellies!! - the Node

Behind the paper: “Topology changes of Hydra define actin orientation defects as organizers of morphogenesis”

thenode.biologists.com

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Reposted by Roux Lab, Geneva

Thomas Lecuit @thomaslecuit.bsky.social · Jun 2

This was a truly exciting talk from Aurelien Roux @rouxlab.bsky.social from Univ. Geneva 👏👏. From his landmark work on membranes to tissues now, the continuing theme is the role of geometry, topology and curvature in morphogenesis. Thanks for visiting us 🤩

CENTURI - Turing Centre for Living Systems @centuri-ls.bsky.social · Jun 2

Aurélien Roux, from Université de Genève, is now holding his CENTURI Seminar on "Topological defects in the orientational order of cells are stress organizers of tissue morphogenesis", hosted by @thomaslecuit.bsky.social

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NordenLab @nordenlab.bsky.social · May 10

The amazing tour de force of the great @lcferme.bsky.social is now out in its final form in @ScienceAdvances (not on Bluesky???). It was hard work and all the conceptual advance was her doing. Check it out: www.science.org/doi/epdf/10....

Timely neurogenesis drives the transition from nematic to crystalline nuclear packing during retinal morphogenesis

You have to enable JavaScript in your browser's settings in order to use the eReader.

www.science.org

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SFB1348 @sfb1348.bsky.social · Apr 29

Just one week to go ⏳ until the "Cellular Interfaces Across Scales: From Molecules to Tissue Dynamics" meeting @sfb1348.bsky.social @uni-muenster.de
We can't wait to see you there!
crc1348-conference.ycode.site
#DynamicCellularInterfaces #Münster

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Sophie G Martin @sophiemartinlab.bsky.social · May 6

The lab is on a roll. 2nd preprint in as many weeks!

High levels of Cdc42 GTPase underlie an all-or-none decision to fuse.

Great team effort led by PhD students @sajjitasaha.bsky.social and @aiswaryasajeevan.bsky.social

www.biorxiv.org/content/10.1...

@biology-unige.bsky.social

High levels of Cdc42 GTPase underlie an all-or-none decision to fuse

Cdc42 is a Rho-family GTPase conserved across eukaryotes, where it plays essential roles in cell polarization. In single-celled yeast systems, Cdc42 is a key driver of symmetry breaking and polarized ...

www.biorxiv.org

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Sophie G Martin @sophiemartinlab.bsky.social · May 2

New lab preprint! High resolution mapping of the actin fusion focus reveals myosin V-dependent transport of formin for actin aster compaction.

A very cool work led by @valthomas.bsky.social and nice collaboration with Andrea Picco and @kaksonen.bsky.social!

www.biorxiv.org/content/10.1...

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Falk Schneider @faldalf.bsky.social · Apr 22

#newPI and time is running.

It has already been a month since I officially joined the University of Warwick as Assistant Professor. I am excited to announce and build the Fluorescence and Membrane Dynamics (FMD) Lab:

warwick.ac.uk/fac/sci/med/...

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De Camilli Lab @pdc-lab.bsky.social · Apr 10

"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology
rdcu.be/ehbaL

The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage

Nature Cell Biology - Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal...

rdcu.be

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Roux Lab, Geneva @rouxlab.bsky.social · Apr 14

Abstract submissions for short talks are still opened until April 20th for the EMBO Escrt meeting 2025. There are plenty of options for short talks, please apply online at meetings.embo.org/event/25-escrt

ESCRT function, evolutionary diversity and mechanism of action

The ESCRTs (Endosomal Sorting Complexes Required for Transport) were discovered in 2002 and became one of the most dynamic fields of research in membrane cell biology. ESCRTs are protein complexes fo…

meetings.embo.org

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Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦ @dudinlab.bsky.social · Apr 7

Thats the proof, that PI to PI knowledge transfer can still work (for now😂).

Yay very happy.

Fabien Burki @fburki.bsky.social · Apr 7

First attempt at #ExM in my lab was a success, after a training boot camp by king of the method @dudinlab.bsky.social. Lots of details to iron out, but here is a pretty picture of Cryptomonas (testbed species) #protistsonsky (confocal: Anne Walraven)

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