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Reposted by Peter van Galen

Peter van Galen @vangalenlab.bsky.social · 10d

Congratulations! * Rapid epigenomic classification of acute leukemia* — the most innovative and impactful application of long-read sequencing and machine learning I know. Happy to be included!! #hemesky 🩸🧬💻🔬

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Peter van Galen @vangalenlab.bsky.social · 10d

Congratulations! * Rapid epigenomic classification of acute leukemia* — the most innovative and impactful application of long-read sequencing and machine learning I know. Happy to be included!! #hemesky 🩸🧬💻🔬

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Peter van Galen @vangalenlab.bsky.social · Sep 6

This new way of looking at cellular diversity in single-cell sequencing is transformative imo, which is why we've taken a similar approach to study aging blood stem cells. Congratulations @dkotliar.bsky.social and @soumya-boston.bsky.social! 🩸🧪🧬 #hemesky

dkotliar.bsky.social @dkotliar.bsky.social · Sep 3

Paper from me, Michelle Curtis, @soumya-boston.bsky.social and co out now in @natmethods.nature.com! We now call it starCAT instead of *CAT but the strategy is the same: Build a catalog of ~50 interpretable T cell gene expression programs + use them to interpret new data nature.com/articles/s41...

Reproducible single-cell annotation of programs underlying T cell subsets, activation states and functions - Nature Methods

TCAT is a pipeline that can simultaneously capture gene expression programs related to T cell subsets and activation states for accurate T cell characterization.

nature.com

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Peter van Galen @vangalenlab.bsky.social · Sep 6

These findings provide new insight into blood aging at the source, and raise the possibility of targeting inflammatory HSCs to "rejuvenate" blood production in aging 🧪
Thanks Ksenia Safina and collaborators @trowbridgelab.bsky.social @bloodgenes.bsky.social Read more at doi.org/10.1101/2025... 5/5🏁

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Peter van Galen @vangalenlab.bsky.social · Sep 6

We discovered a type of stem cells that expand with age and is dominated by a program of inflammation and quiescence (GEP:1 below), which could leave the blood system less able to renew itself 📊 4/5

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Peter van Galen @vangalenlab.bsky.social · Sep 6

There is no clear agreement on the effects of aging on HSCs, and how different types of HSCs play into this. So we pulled seven datasets together and re-analyzed them using new bioinformatic methods, revealing a clearer picture 💻 3/5

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Peter van Galen @vangalenlab.bsky.social · Sep 6

Aging of blood system leads to health problems such as weakened immunity and a higher risk of anemia. Many of these changes can be traced back to HSCs, which reside in the bone marrow and renew all blood cells 🔬 2/5

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Peter van Galen @vangalenlab.bsky.social · Sep 6

Excited to share our latest work on blood aging! To find out why the blood system changes as people age, we started at the source: hematopoietic stem cells (HSCs) #hemesky 🩸🧬 doi.org/10.1101/2025... 🧵 1/5

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Peter van Galen @vangalenlab.bsky.social · Sep 6

There is no clear agreement on the effects of aging on HSCs, and how different types of HSCs play into this. So we pulled seven datasets together and re-analyzed them using new bioinformatic methods, revealing a clearer picture 3/5

Peter van Galen @vangalenlab.bsky.social · Sep 6

Aging of blood system leads to health problems such as weakened immunity and a higher risk of anemia. Many of these changes can be traced back to HSCs, which reside in the bone marrow and renew all blood cells 2/5

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Peter van Galen @vangalenlab.bsky.social · Aug 15

New insights into the Unfolded Protein Response in hematopoietic stem cells in @bloodjournal.bsky.social this week + commentary from @basitsalik.bsky.social and me🩸🐁 #hemesky doi.org/10.1182/bloo...

The PERKs of ER homeostasis for hematopoietic stem cells

In this issue of Blood, Zheng et al1 show that the unfolded protein response (UPR) sensor PERK (protein kinase R-like endoplasmic reticulum kinase) is disp

doi.org

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Peter van Galen @vangalenlab.bsky.social · Aug 15

Online today! *Aging, Immune Fitness and Cancer* 🔬 Learn the latest about the intersection between these processes in
@natrevcancer.nature.com 🧬 Great to work with
@sandramcallister.bsky.social lab again 😁 doi.org/10.1038/s415...

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Peter van Galen @vangalenlab.bsky.social · Aug 5

This may be my favorite paper of the year so far: integrating single-cell leukemia datasets to reveal how differentiation and mutations interact to drive disease, along with a tool that speeds up bone marrow cell annotation from ~4 weeks to ~4 hours..! aacrjournals.org/bloodcancerd... 🔬🩸🧬 #hemesky

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Peter van Galen @vangalenlab.bsky.social · Aug 5

Noted!

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Peter van Galen @vangalenlab.bsky.social · Aug 4

Whenever the team @posit.co brings out a new feature, it’s exactly how I wished it would be. AI integration done right 🧠 positron.posit.co/assistant @anthropic.com

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Reposted by Peter van Galen

Vikram Paralkar @paralkarlab.bsky.social · Aug 2

📣 New preprint 📣

We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.

Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)

Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis

Transcription of ribosomal RNAs (rRNAs) from rDNA repeats is the first step of ribosome biogenesis, accounting for a major portion of all cellular transcription. Often regarded as a housekeeping proce...

www.biorxiv.org

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Peter van Galen @vangalenlab.bsky.social · Aug 2

Had a great time catching up with friends and learning new science at FASEB Hematologic Malignancies! #hemesky @faseborg.bsky.social #HEMSRC

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Reposted by Peter van Galen

Vikram Paralkar @paralkarlab.bsky.social · Jul 30

At the FASEB Heme Malignancies meeting with old friends and new - Pam Sung, Peter Van Galen (@vangalenlab.bsky.social), Julia Maxson (@juliamaxson.bsky.social), Johnathon Shafer. Trying out ales at the @treehousebrewing.bsky.social! #HEMSRC

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Peter van Galen @vangalenlab.bsky.social · Feb 22

#positron is rapidly replacing programs and websites I used with a customizable multilingual coding environment for data science (local+cluster+virtual machines) #bash #rstats #python @posit.co

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Reposted by Peter van Galen

Ann Mullally @mullallylab.bsky.social · Jan 10

Delighted to share our #hematology review article on mutant calreticulin in #MPN
Congrats to co-authors Drs. Mifra Faiz, Merle Riedemann & Jonas Jutzi. We hope it’s a useful resource, link below! @stanforddeptmed.bsky.social
link.springer.com/article/10.1...

Mutant Calreticulin in MPN: Mechanistic Insights and Therapeutic Implications - Current Hematologic Malignancy Reports

Purpose of Review More than a decade following the discovery of Calreticulin (CALR) mutations as drivers of myeloproliferative neoplasms (MPN), advances in the understanding of CALR-mutant MPN continu...

link.springer.com

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Peter van Galen @vangalenlab.bsky.social · Jan 11

Erasmus MC Hematology Lecture speaker lineup never fails to impress! #hemesky 🧪🩸 mcusercontent.com/71bcc0f3bb8a...

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Peter van Galen @vangalenlab.bsky.social · Jan 4

Just a reminder of what is easily in my top 5 of favorite papers from 2023 www.cell.com/iscience/ful... @bailee-kain.bsky.social @thekinglab.bsky.social

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Peter van Galen @vangalenlab.bsky.social · Jan 1

Congrats! Look forward to using it

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Peter van Galen @vangalenlab.bsky.social · Dec 23

Our latest work is now available to read on bioRxiv! Very proud of this and its potential implications for patients with acute myeloid leukemia 🩸 🧪 🔬💊 **eIF4A-mediated translation initiation as an AML cell vulnerability that can be co-targeted with BCL-2 inhibition** www.biorxiv.org/content/10.1...

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Peter van Galen @vangalenlab.bsky.social · Dec 22

Boston’s North End ❄️

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