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Reposted by Gaurav Varshney

Megan Dennis @mydennis.bsky.social · 13d

While I'm sad our cover submission wasn't selected for our recent human duplication paper, check out the super cool illustration created with @lazaroillustration.bsky.social ! Certainly, you will be seeing Dennis lab members running around with "fishman" t-shirts at future meetings, inspired by Ohno

Javier Lazaro - illustration @lazaroillustration.bsky.social · 13d

"Fishman", proposal for a journal cover.
Commissioned by MY Dennis' lab @mydennis.bsky.social for a study focused on identifying human-specific gene duplications and their role in brain evolution using genomics and zebrafish as model. @dcsoto.bsky.social
#art #digitalart #sciart #fish

Illustration of a fishman creature with human limbs and fish head and tail, interacting with a DNA string

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Gaurav Varshney @varshneylab.social · Sep 6

Does anyone have #zebrafish LC3 reporter lines and would be willing to share them with us? #askzebrafish

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Reposted by Gaurav Varshney

Shawn Burgess @burgesslab.bsky.social · Aug 15

#zebrafish genome update, our T2T assembly of the inbred strain of AB (M-AB) generated by my buddy Nori Sakai has now been released at NCBI and will be a second reference genome for zebrafish (GRCz12ab):

JBQAYU000000000.1 Danio rerio :: NCBI

www.ncbi.nlm.nih.gov

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Gaurav Varshney @varshneylab.social · Aug 6

Best wishes!

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Gaurav Varshney @varshneylab.social · Aug 6

I do it at least 2-3 times a day!

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Gaurav Varshney @varshneylab.social · Aug 5

Even if you do it from a phone, it will not be cleared elsewhere!

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Gaurav Varshney @varshneylab.social · Aug 2

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Gaurav Varshney @varshneylab.social · Aug 1

Congratulations!

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Gaurav Varshney @varshneylab.social · Jul 31

CRISPR technologies have transformed genetic research since their adaptation for genome editing in 2012. @burgesslab.bsky.social and I summarize key functional genomics tools being used in vertebrate models. www.nature.com/articles/s12...

CRISPR-based functional genomics tools in vertebrate models - Experimental & Molecular Medicine

Recent advances in DNA sequencing have allowed scientists to gather vast amounts of genetic data, but understanding what those sequences actually do requires additional tools that allow scientists to ...

www.nature.com

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Gaurav Varshney @varshneylab.social · Jul 22

Congratulations, Megan! As always inspiring work.

Megan Dennis @mydennis.bsky.social · Jul 21

Check out our latest work co-led by @dcsoto.bsky.social and @jmuribescr.bsky.social identifying hundreds of human duplicated gene families using the new T2T-CHM13 assembly, with a focus on those potentially contributing to brain evolution 🧪: authors.elsevier.com/a/1lTQtL7PXu...

authors.elsevier.com

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Gaurav Varshney @varshneylab.social · Jul 21

By engineering TadA-based cytosine base editors with enhanced PAM flexibility and reduced off-targets, we overcome key limitations of existing CBEs, including poor editing at CC and GC motifs.

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Gaurav Varshney @varshneylab.social · Jul 21

Our paper on TadA-based cytosine base editors is now online in Advanced Science. We introduce zTadCBEs—a next-generation CRISPR base editor optimized for zebrafish.
advanced.onlinelibrary.wiley.com/doi/10.1002/...

Rationally Designed TadA‐Derived Cytosine Editors Enable Context‐Independent Zebrafish Genome Editing

A next-generation cytosine base editor (zTadCBE) and other variants are developed by combining the high-efficiency (TadCBEa) and low-indel (TadCBEMax) architectures, followed by the introduction of z....

advanced.onlinelibrary.wiley.com

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Gaurav Varshney @varshneylab.social · Jul 18

Congratulations!

Christian Mosimann @chrmosimann.bsky.social · Jul 16

Grateful to receive an R24 NOA from NIH/ORIP to advance phiC31-based transgenesis tools in #zebrafish. 🐟

Collab with @aburger2009.bsky.social & Breuss labs @cuanschutz.bsky.social. 🧬

...and: big THX to everyone who already helped w/ sharing #pIGLET reagents! 🐽
#ShareYourTools #MakeMoreTransgenics

piglet from winnie the pooh says thank you

ALT: piglet from winnie the pooh says thank you

media.tenor.com

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Reposted by Gaurav Varshney

Kristen Kwan @blockintheback.bsky.social · Jul 7

🚨🚨🚨 Tol2kit announcement! We have rebuilt the wiki that was corrupted a few months ago! We’re in the process of also linking it to the original address. Please visit us here:
tol2kitkwan.genetics.utah.edu
Thank you for your patience!!
#zebrafish #transgenesis #plasmids #sharing

tol2kit for kwan lab

tol2kitkwan.genetics.utah.edu

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Reposted by Gaurav Varshney

Ferenc Mueller @ferencmueller.bsky.social · Jul 11

Dear #izfc2025 participants, if anyone of you are interested in how transcription control defines mRNA fate and translation in zebrafish development, there are/will be several PhD and postdoctoral positions (funded by the Wellcome Trust) for this research. Please find me if interested.

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Reposted by Gaurav Varshney

Kristen Kwan @blockintheback.bsky.social · Jul 11

The winners of the 2025 George Streisinger Award are the Course Directors of the Zebrafish Development and Genetics course at MBL, for their tremendous contributions to our amazing community for >25 years! #izfc2025

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Gaurav Varshney @varshneylab.social · Jun 18

The new impact factors are out: Development – 3.6, Developmental Cell – 8.7. Why the steady decline in two of Dev Bio's flagship journals?

Gaurav Varshney @varshneylab.social · Jun 15

What! That's where I worked. So many fond memories. 😭

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Gaurav Varshney @varshneylab.social · Jun 15

Terrible! What building is it? I spent a year in this amazing campus.

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Reposted by Gaurav Varshney

Xenbase @xenbase.bsky.social · Jun 5

Please read and share this opinion piece written by Carole LaBonne (our fellow Xenopus researcher) published in STAT in support for animal models in biomedical research. www.statnews.com/2025/05/19/a... #science #devbio #xenopus #frogs

There is no replacement (yet) for animal models in medical research

The NIH is “reducing animal use in research.” But there is no replacement for animal models.

www.statnews.com

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Reposted by Gaurav Varshney

Zebrafish Rock! @zebrafishrock.bsky.social · May 10

With a published genome & advancements in gene editing, the field of #zebrafish genetics has exploded in recent decades. We take a look back at major achievements in this infographic. For more, read this book chapter by @varshneylab.social et al (2015)($) doi.org/10.1016/bs.a... #ZebrafishFunFacts 🧪

Timeline of important technological developments in zebrafish research.

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Gaurav Varshney @varshneylab.social · May 2

Get ready to pay extra for your supplies and reagents.

Reposted by Gaurav Varshney

Genetics Society of America @genetics-gsa.bsky.social · Apr 30

Welcome @burgesslab.bsky.social as an Associate Editor for #GENETICS 👋 Burgess, who will be joining the Experimental Technologies and Resources section, studies tissue regeneration in zebrafish and genome function. We’re delighted to have him on the team! Read more: buff.ly/k0yDk5c

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Gaurav Varshney @varshneylab.social · Apr 22

Congrats Ben and team!

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