It will be an opportunity to discuss complex menopause cases (theme of the session - Menopause for Women with Pre Existing Health Conditions) and address practical clinical questions for all of us.

Named after the Earl of Orrery, these intricate devices, often made of brass and ivory, demonstrate the heliocentric (Sun-centered) universe but aren't usually to scale due to vast size differences.

An orrery is a mechanical model of the solar system, using gears and clockwork to show the relative motions and positions of the Sun ☀️, planets 🌎, and sometimes moons 🌒, illustrating astronomical cycles like orbits, seasons, and lunar phases.

Every piece of research matters - the aim is to understand the strengths and weaknesses of these studies/recommendations and how to make their best use in clinical practice.

Join us live on Monday 19th January at 6:45 pm or watch later on YouTube MREF channel.

We will aim to cover HRT after BRCA diagnosis; GSM, UTIs and vaginal oestrogen; Vaginal oestrogen and rectal cancer; Meningioma and HRT; Aging and HRT and Testosterone in menopause - the recent North American society guidelines.

Here is a take on PDE5 inhibitors and their potential. A rationale for PDE5 inhibitors as a cardiovascular risk mitigation strategy in postmenopausal women. doi: doi.org/10.1093/jsxm...

There is a need to develop this space more with better research into both lifestyle and medical treatments including hormonal (HRT) and non-hormonal strategies.

But can they have another role for women in menopause transition and beyond? We know that there is a lack of good quality female-specific research and preventative interventions when it comes to cardiovascular health in women.

Initially developed as a potential intervention for cardiovascular disease, the drugs including sildenafil (Viagra) are today used for treatment of erectile dysfunction and pulmonary hypertension.

These medications work by blocking the action of the enzyme PDE5, which is responsible for breaking down cyclic GMP (cGMP) in the smooth muscle cells. By inhibiting PDE5, these drugs promote the accumulation of cGMP, leading to vasodilation in the smooth muscle cells of the blood vessels.

Thank you Riya Philip from the University of Glasgow for taking this forward.
If you are able to participate, please click - forms.gle/J4BBPesijGX7... or scan the QR code
or share with someone who may be interested.

Menopause transition will potentially affect 50% or more of the population, however education on this topic for undergraduate medical students appears to be limited.

You can find out more about article submission at -
[email protected] 

Or click

raf.bioscientifica.com/page/menopau...

Continued…..
* Premature ovarian insufficiency and early menopause
* Menopause and Cognitive health 
* Testosterone therapy during menopause
* Managing menopause after cancer
* Addressing global inequalities in menopause care and support - how do we overcome barriers and challenges that lie ahead?

Key areas we will aim to cover -
* Management of menopause symptoms with non-hormonal therapies and the advent of novel therapies like NK-3 receptor antagonists  
* Hormone replacement therapy for menopause - where are we now?
* Cardiovascular and bone health in menopause 
Continued……

Reproduction and Fertility has a global readership and an Impact Factor of 3.4 (Q1 journal).
Co-Editors in Chief -
Andrew Horne, PhD FRCOG FRCP Edin FRCSEd FRSE
Professor of Gynaecology and Reproductive
Sciences
and
Norah Spears, D Phil
Professor of Reproductive Physiology

Here are some of the free patient information resources we created at London Medical -

londonmedical.co.uk/gp-services/...

londonmedical.co.uk/news-and-eve...

londonmedical.co.uk/news-and-eve...

And finally not to forget all the patients who have been an amazing source of learning in this journey. - thank you!