Vishal Patel
@vishal-d-patel.bsky.social
Physician-Scientist l Professor I Nephrologist l Polycystic Kidney Disease & Genetics l miRNAs, ncRNAs, RNA-therapeutics, Anti-miRs/ASOs l @UTSWNews
🧬 In #ADPKD, reduced PKD1 drives cyst growth and kidney failure.
We previously discovered a 55bp cis-repressive element in its 3'UTR.
We now identify the six critical bases—the miR-17 motif—whose disruption or masking restores PKD1 and slows disease
We previously discovered a 55bp cis-repressive element in its 3'UTR.
We now identify the six critical bases—the miR-17 motif—whose disruption or masking restores PKD1 and slows disease
Disruption of a six-nucleotide miRNA motif improves PKD1 dosage and ameliorates polycystic kidney disease https://www.biorxiv.org/content/10.1101/2025.10.22.683929v1
October 24, 2025 at 3:50 AM
🧬 In #ADPKD, reduced PKD1 drives cyst growth and kidney failure.
We previously discovered a 55bp cis-repressive element in its 3'UTR.
We now identify the six critical bases—the miR-17 motif—whose disruption or masking restores PKD1 and slows disease
We previously discovered a 55bp cis-repressive element in its 3'UTR.
We now identify the six critical bases—the miR-17 motif—whose disruption or masking restores PKD1 and slows disease
It was a pleasure to write this commentary. Thank you for the invite
@jclinical-invest.bsky.social
@jclinical-invest.bsky.social
Uromodulin modulates mitochondria and kidney tubule resilience: buff.ly/LI0BKQI
@vishal-d-patel.bsky.social, Ronak Lakhia & Chunzi Song provide a Commentary on Nanamatsu et al. (buff.ly/JDVUQv3)
@vishal-d-patel.bsky.social, Ronak Lakhia & Chunzi Song provide a Commentary on Nanamatsu et al. (buff.ly/JDVUQv3)
June 20, 2025 at 7:47 PM
It was a pleasure to write this commentary. Thank you for the invite
@jclinical-invest.bsky.social
@jclinical-invest.bsky.social
Thrilled to share our new work in Nature Communications!
We discovered how methionine → SAM → METTL3 → RNA methylation axis guides kidney development, especially nephron progenitor differentiation. #Nephrology #Epitranscriptomics
Here’s a quick breakdown
www.nature.com/articles/s41...
We discovered how methionine → SAM → METTL3 → RNA methylation axis guides kidney development, especially nephron progenitor differentiation. #Nephrology #Epitranscriptomics
Here’s a quick breakdown
www.nature.com/articles/s41...
An RNA transmethylation pathway governs kidney nephrogenic potential - Nature Communications
The mechanisms governing kidney nephrogenic capacity are incompletely understood. Here, the authors reveal that METTL3-dependent RNA transmethylation is both necessary and sufficient to promote nephro...
www.nature.com
May 28, 2025 at 8:18 PM
Thrilled to share our new work in Nature Communications!
We discovered how methionine → SAM → METTL3 → RNA methylation axis guides kidney development, especially nephron progenitor differentiation. #Nephrology #Epitranscriptomics
Here’s a quick breakdown
www.nature.com/articles/s41...
We discovered how methionine → SAM → METTL3 → RNA methylation axis guides kidney development, especially nephron progenitor differentiation. #Nephrology #Epitranscriptomics
Here’s a quick breakdown
www.nature.com/articles/s41...
Texas fall evening....beautiful Lake Grapevine
November 17, 2024 at 11:53 PM
Texas fall evening....beautiful Lake Grapevine