Bin Wan
@wanb.bsky.social
150 followers 290 following 23 posts
Computational Neurogenetics PostDoc @ Geneva Psychiatry PhD @mpicbs.bsky.social Personal web: https://wanb-psych.netlify.app/
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wanb.bsky.social
Happy to share my last PhD work "Genetic, transcriptomic, metabolic, and neuropsychiatric underpinnings of cortical functional gradients". We used UKB, HCP, and QTAB to analyze the genetics of functional gradients. The results are so good, consistent, and inspiring! (1/3)
wanb.bsky.social
congrats!Valerie
Reposted by Bin Wan
gradientsworkshop.bsky.social
It's a wrap! BIG thanks to all speakers, chairs, attendees, and our organizing committee - particularly our superstar local organizers Johan and Saurabh - for making our gradient dreams come true for the sixth year in a row ⭐ 🌈 🧠 🚀
Reposted by Bin Wan
ohbmtrainees.bsky.social
🎉🎉#OHBM2025 is just around the corner! Remember to visit the SP-SIG stall next to the registration desk and add stickers to your badge describing your research interests!
wanb.bsky.social
I finally defended my thesis! Thanks all! I started my PhD during covid! I am really grateful that my supervisor @sofievalk.bsky.social picked me to be her first PhD student when I was naive to neuroimage. I have been so lucky to stay in this happy and respectful academic environment so far!
wanb.bsky.social
Congrats bro!
Reposted by Bin Wan
Reposted by Bin Wan
amnsbr.bsky.social
🧠⚖️📉 How does the cortical excitation-inhibition ratio mature during adolescence?
We asked this in our new paper just out in #ScienceAdvances
“Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling”
📄 www.science.org/doi/full/10....
🧵⤵️
Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling
Individualized simulations reveal a decrease in excitation-inhibition ratio in association areas throughout adolescence.
www.science.org
Reposted by Bin Wan
apertureohbm.bsky.social
Merchant et al. perform a meta-analytic investigation of neurocognitive systems involved in real-time social interaction doi.org/10.52294/001...

@fmri-today.bsky.social @mallarchak.bsky.social @ohbmofficial.bsky.social
Reposted by Bin Wan
maciekszul.bsky.social
🚨🚨🚨PREPRINT ALERT🚨🚨🚨
Neural dynamics across cortical layers are key to brain computations - but non-invasively, we’ve been limited to rough "deep vs. superficial" distinctions. What if we told you that it is possible to achieve full (TRUE!) laminar (I, II, III, IV, V, VI) precision with MEG!
Overview of the simulation strategy and analysis. a) Pial and white matter boundaries
surfaces are extracted from anatomical MRI volumes. b) Intermediate equidistant surfaces are
generated between the pial and white matter surfaces (labeled as superficial (S) and deep (D)
respectively). c) Surfaces are downsampled together, maintaining vertex correspondence across
layers. Dipole orientations are constrained using vectors linking corresponding vertices (link vectors).
d) The thickness of cortical laminae varies across the cortical depth (70–72), which is evenly sampled
by the equidistant source surface layers. e) Each colored line represents the model evidence (relative
to the worst model, ΔF) over source layer models, for a signal simulated at a particular layer (the
simulated layer is indicated by the line color). The source layer model with the maximal ΔF is
indicated by “˄”. f) Result matrix summarizing ΔF across simulated source locations, with peak
relative model evidence marked with “˄”. g) Error is calculated from the result matrix as the absolute
distance in mm or layers from the simulated source (*) to the peak ΔF (˄). h) Bias is calculated as the
relative position of a peak ΔF(˄) to a simulated source (*) in layers or mm.
Reposted by Bin Wan
anniegbryant.bsky.social
🎨🧑‍🎨 Looking for a tool to visualize subcortical/thalamic data in 2D? Check out this python-based package I put together (subcortex-visualization on PyPI), plus a guide for creating your own custom atlas meshes and vector graphics! All feedback/tips welcome 😊

anniegbryant.github.io/subcortex_vi...
wanb.bsky.social
See our GWAS of grapical topology🤟
vw1234.bsky.social
Pleased to share new work from our group, led by PhD student Edward He. Edward joined the group as a summer student interested in the genetics of resting state functional connectivity, measured using graph networks.

www.medrxiv.org/content/10.1...
www.medrxiv.org
Reposted by Bin Wan
enigmabrains.bsky.social
As always, it was great fun to connect with our ENIGMA Consortium community last night at #SOBP2025 in Toronto - thanks to all who joined us! Cheers to science and the next SOBP conference🍻🧠
Reposted by Bin Wan
borismontreal.bsky.social
in press @natcomms.nature.com 🌟

"Multimodal gradients unify local and global cortical organization"

7T MRI + cytoarchitectonics reveal a sensory-paralimbic axis of areal specialization & integration

led by superstar Yezhou Wang & a terrific team of friends & colleagues

▶️ doi.org/10.1038/s414...
wanb.bsky.social
that‘s pretty
wanb.bsky.social
Thanks for the coauthors! Yuankai He, Varun Warrier, @johnalexandra.bsky.social, Matthias Kirschner, @sbe.bsky.social, @raibethlehem.bsky.social, @sofievalk.bsky.social (3/3).
wanb.bsky.social
1) The heritability was robust across samples of different ages
2) GWAS identified 16 genes, involved in metabolic process
3) The genes were further validated using Allen Brain
4) Individual protective and risk metabolic makers showed reversed correlations
5) SCZ, PTSD, and BP won the game
(2/3)
wanb.bsky.social
Happy to share my last PhD work "Genetic, transcriptomic, metabolic, and neuropsychiatric underpinnings of cortical functional gradients". We used UKB, HCP, and QTAB to analyze the genetics of functional gradients. The results are so good, consistent, and inspiring! (1/3)