Mr Wickham
LightNews LightNews
Mr Wickham
@wickham.bsky.social
40 followers 12 following 6 posts
Posts Replies Media Videos
Reposted by Mr Wickham
thedownslab.bsky.social
Congratulations to Dr Noa Amin (times two since she was already a medical doctor but now has an amazing PhD)!!! #proudsupervisor Beautiful @icr.ac.uk award ceremony at the Guildhall
Photo of the London Guildhall
October 27, 2025 at 7:37 PM
Reposted by Mr Wickham
thedownslab.bsky.social
Now out! Led by @susana-sousa.bsky.social and Noa Amin, and thanks to our collaborators in the Harrington @icr.ac.uk and Stucki and Choudhary @jc4-jyoti.bsky.social labs

www.cell.com/cell-reports...
September 16, 2025 at 3:30 PM
Reposted by Mr Wickham
thedownslab.bsky.social
Beautiful #pyrenees 😍. Totally refreshed and decompressed.

Wonder how long that will last....
August 25, 2025 at 2:47 PM
Reposted by Mr Wickham
thedownslab.bsky.social
Congratulations 🥳 @alison-harrod.bsky.social for winning the oral communication prize at the Biochemical Society Alternative Nucleic Acid Topology meeting for her talk on SMARCA4 and G quadruplexes! 🎉👏🎉
July 18, 2025 at 5:39 AM
Reposted by Mr Wickham
thedownslab.bsky.social
And @lillianwu.bsky.social presented a poster with her PhD thesis work on CENPB!
photo of Lillian in front of her poster
July 4, 2025 at 2:09 PM
Reposted by Mr Wickham
thedownslab.bsky.social
Many of these were from the @icr.ac.uk conference, which was a great opportunity to catch up with colleagues. And drink beer.
Photo of people in the lab drinking beer
July 4, 2025 at 2:09 PM
Reposted by Mr Wickham
thedownslab.bsky.social
Alison also presented her work as a poster (and will be attending the upcoming AlterNat Biochem Soc meeting if anyone wants to hear more!)
photo of Alison in front of her poster
July 4, 2025 at 2:09 PM
Reposted by Mr Wickham
thedownslab.bsky.social
@kezlane.bsky.social Karen Lane presented work she did with @susana-sousa.bsky.social and Noa Amin on ARID1A and G4s (not her main project - watch this space for a project coming out soon on cohesin dynamics in SWI/SNF deficient cells)
photo of Karen giving a talk
July 4, 2025 at 2:09 PM
Reposted by Mr Wickham
thedownslab.bsky.social
A little shout-out to the lab, who have been out in force lately presenting their work! Starting with @alison-harrod.bsky.social talking about her work with Pedro Zuazua Villar and @naghamg.bsky.social on SMARCA4 and G quadruplexes
photo of Alison giving a seminar
July 4, 2025 at 2:09 PM
Reposted by Mr Wickham
thedownslab.bsky.social
New preprint from the lab on ARID1A, G quadruplexes, and repair:
www.biorxiv.org/content/10.1...
ARID1A stabilises non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin
ARID1A is a subunit of the BAF chromatin remodelling complex that is frequently mutated in cancer. It is challenging to predict how ARID1A loss impacts cancer therapy response because it participates ...
www.biorxiv.org
May 27, 2025 at 5:32 PM
Reposted by Mr Wickham
thedownslab.bsky.social
Hey, look at this story that our @postdockatie.bsky.social wrote! magazine.eacr.org/nobel-prize-...
Nobel prize-winning technology in cancer care - The Cancer Researcher
Katalin Karikó's work into mRNA vaccines
magazine.eacr.org
March 19, 2025 at 7:43 AM
Reposted by Mr Wickham
petersagal.bsky.social
This letter appeared in the Bloomsburg PA Press Enterprise this morning. I am assured the writer is who he purports to be, an Air Force veteran.
benion Grieving a wasted life At a point in life when there are far too many days behind than ahead, one tends to re-elected in contrast to standing up for the reflect on a life lived. In my lifetime decades greater good? were devoted to protecting America. Sacri A compromised Supreme Court recently fices were made both by myself and my fam- trotted out a shallow token standards of Ily in military service. The tip of the spear: conduct for themselves. Apparently it's Countless weeks over the years were spent not a bribe to accept favors after a deci-sion; only before. Corporations are people? living at the end of a runway on alert with an Really? Whatever happened to Superman's armed B-52 as generations of aviators have motto of "truth, justice, and the American done before and since. way?" The purpose: if required, be airborne Pay-to-play is the theme of the day. Un- in minutes on a one-way trip bringing a challenged and uncontested blatant conflicts nuclear Armageddon to an adversary. Fly: of interest abound. The rule of law is situ- ing the unfriendly skies over North Viet- ational if adhered to at all. America can no nam provided a brief interlude, but overall, longer be trusted. The unbridled pursuit of this long line of silent sentinels stood firm power and wealth driven by unquenchable to protect America by deterring external greed has left service above self and Con- threats to our freedoms and way of life stitutional norms in the dustbin of a quaint across the decades. I was privileged to serve past. with men and women of integrity imbued Recently the VA said exposure to Agent with a sense of service. Orange is the probable cause of the can- I'm truly grateful that the B-52s we flew, which were built tough, were engineered cers I live with. Actually I suspect it's more from yet unspecified sources, which cause on scientific principles and fabricated by experienced, skilled workers rather than military pilots to have significantly higher founded on mere beli…
March 11, 2025 at 10:04 PM
Reposted by Mr Wickham
thedownslab.bsky.social
Congratulations @kezlane.bsky.social and @alison-harrod.bsky.social and thanks to all our fabulous collaborators!
March 5, 2025 at 2:32 PM
Reposted by Mr Wickham
thedownslab.bsky.social
These are two awesome, talented postdocs! Lucky to have them in the lab 😍
alison-harrod.bsky.social Alison Harrod @alison-harrod.bsky.social · Feb 28
Cheers @kezlane.bsky.social to our co-first author paper on PBRM1 and the centromere being published this week in @naturecomms.bsky.social! @thedownslab.bsky.social @icr.ac.uk
March 5, 2025 at 2:33 PM
Reposted by Mr Wickham
thedownslab.bsky.social
If you like chromatin remodellers and centromeres, this might be of interest. In it, we generated omics data from isogenic PBRM1 cell lines, which we hope is of use to the community, freely available (when evil forces aren't messing with the publicly funded websites 🙄) www.nature.com/articles/s41...
PBRM1 directs PBAF to pericentromeres and protects centromere integrity - Nature Communications
Centromere fragility can drive tumourigenesis, so protective mechanisms are important. Here, the authors suggest that the PBAF chromatin remodelling complex, which is frequently misregulated in cancer...
www.nature.com
March 5, 2025 at 2:44 PM
Reposted by Mr Wickham
thedownslab.bsky.social
Lab retreat 2024! We had days of excellent science, food, ideas, food, games, food, discussions, food, and brainstorming.
And snacks.
November 30, 2024 at 5:52 PM