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Bill Wuest @wmwuest.bsky.social · 12d

New NSF GRFP announcement is out. MAJOR CHANGE: Only senior UG and 1st year grad students appear to be eligible..... Why the change? Anyone know?

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Bill Wuest @wmwuest.bsky.social · 12d

Looks like this worked. Solicitation is up and deadline was moved back 2 weeks. Nice job.

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Reposted by Bill Wuest

Jason Williams @jasonwilliamsny.bsky.social · 13d

Please share with anyone who cares about NSF support for graduate students and take 30 seconds to sign and leave a comment.

The deadline for the 2025 Graduate Research Fellowship Program is about one month away and literally no one can apply. #NSFGRFP

jasonjwilliamsny.github.io/grfp2025/

An Open Letter to U.S. STEM Leadership on the NSF Graduate Research Fellowship Program

jasonjwilliamsny.github.io

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Reposted by Bill Wuest

Drug Monkey @drugmonkey.bsky.social · 13d

This may be the most important paper ever published about NIH funded research.

www.science.org/doi/10.1126/...

What if NIH had been 40% smaller?

Replaying history with less NIH funding shows widespread impacts on drug-linked research

www.science.org

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Bill Wuest @wmwuest.bsky.social · Jul 5

Also worth pointing out the MIRA mechanism, which sounds closer to what was suggested - betting on the athlete not the proposal. With all the cuts I worry this program won’t be able to continue as intended or planned.

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Bill Wuest @wmwuest.bsky.social · Jun 14

I believe nigms cancelled f31s awhile back.

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Bill Wuest @wmwuest.bsky.social · May 29

I dont have that data (I think that med school accepts seem similar) but I do not think this 5 course sequence is THAT different that a normal 2 semester gen chem, 2 semester organic, quantum sequence, with a little biochem added. The bigger difference is the electives needed to be offered after.

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Bill Wuest @wmwuest.bsky.social · May 29

Nope not quite what we do. 1st semester is structure-focused (~95% gen chem), 2nd is 70/30 gen chem/orgo, focusing on equilibria mainly, 3rd is 100% orgo, 4th is ~50/50 orgo/biochem. 5th is p chem (quantum mostly). These are my own estimates but am fairly familiar with the curriculum.

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Bill Wuest @wmwuest.bsky.social · May 16

I typically review all files twice a year (week before enrollment). I actually make this a lab job for a grad student aspiring to be pui faculty and they help organize and conduct the interviews too.

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Bill Wuest @wmwuest.bsky.social · May 16

Oh I agree but I have found that by asking the right questions we can trim the number down to 4-5 then conduct brief zoom interviews to land on the best fits, at least imo. Success rate and long term retention have gone up and students really appreciate the clarity.

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Bill Wuest @wmwuest.bsky.social · May 16

Instead of relying on emails why not create an application form for anyone interested to complete? Then they won’t have to guess at what you are looking for & you can level the playing field for all. We have found this approach super useful in my lab! Happy to share more info if you are interested.

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Bill Wuest @wmwuest.bsky.social · May 13

Ours at Emory is also happening.

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Bill Wuest @wmwuest.bsky.social · May 6

Has anyone else received manuscript reviews that were AI-assisted? We got our 1st one. Text raised suspicions & was "verified" by GPTzero as 90% AI. Assuming that our manuscript had to be uploaded to a system to then be reviewed raises copyright and privacy concerns. Are there any repurcussions?

Bill Wuest @wmwuest.bsky.social · Apr 26

I have that exact record in my office! I remember reading the background and finding it online.

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Bill Wuest @wmwuest.bsky.social · Apr 22

Yeah, they were very close to approval by a startup company (Phase 3 I think). However, the IPO to fund the trial was "shorted" by investors and ended up bankrupting the company. I believe Roche picked up the IP. It is sad how often this happens in ABX research....

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Bill Wuest @wmwuest.bsky.social · Apr 22

What Stephan meant to say is no 🙂, him and I are on another paper together led by Stephan Sieber published in Nat Chem. It's really cool IMO: www.nature.com/articles/s41...

Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms - Nature Chemistry

Screening commercial kinase inhibitors for antibacterial activity identified the anticancer drug sorafenib as a major hit. Subsequent structure–activity optimization created a new antibacterial analog...

www.nature.com

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Bill Wuest @wmwuest.bsky.social · Apr 22

I use this paper in my chem Bio class as well. So good! Crazy this compound hasn’t made it to the market imo.

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Reposted by Bill Wuest

Steve Diggle @digglelab.bsky.social · Apr 15

www.bbc.com/news/article...

Three million child deaths linked to drug resistance

Children in Africa and South East Asia are most at risk from antibiotics medicines no longer working, a study suggests.

www.bbc.com

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Bill Wuest @wmwuest.bsky.social · Apr 9

you and me both. i even got my RPPR in 8 weeks early and realized one journal put a 12 month embargo on them instead of the necessary 3.....ugh.

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Bill Wuest @wmwuest.bsky.social · Apr 9

I am getting very nervous about NIHMS service. If papers aren't uploaded there then grants can technically be withheld. The delay for NIHMS uploading has noticeably increased. Any word on this infrastructure??

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Bill Wuest @wmwuest.bsky.social · Apr 8

we are due for some wins, right? maybe? ugh.....

Bill Wuest @wmwuest.bsky.social · Apr 8

Sounds like there might be plans to award additional fellowships from the HM list down the road. Perhaps they wanted to get out the UG specific awards ASAP to allow for grad school accepts? Perhaps I am being too optimistic....

Bill Wuest @wmwuest.bsky.social · Apr 8

NSF GRFP Awards by the Year:
2021 - 2074
2022 - 2193
2023 - 2555
2024 - 2036
2025 - 1000

Again, these funding cuts will have drastic longterm effects on the scientific future of the US.......

@jeremymberg.bsky.social @altnih4science.bsky.social

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Bill Wuest @wmwuest.bsky.social · Apr 8

NSF GRFP Awards by the Year:
2021 - 2074
2022 - 2193
2023 - 2555
2024 - 2036
2025 - 1000

Again, these funding cuts will have drastic longterm effects on the scientific future of the US.......

@jeremymberg.bsky.social @altnih4science.bsky.social

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Bill Wuest @wmwuest.bsky.social · Apr 4

Congrats Erin!! Well deserved!

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Reposted by Bill Wuest

Keith Boykin @keithboykin.bsky.social · Mar 23

Rodney Taylor is a beloved Georgia barber who came to the United States from Liberia with his mother when he was only two years old. He applied for citizenship but was denied. But this year, ICE arrested him, locked him up, and has scheduled him to be deported to a faraway country he's never known.

Recently engaged, beloved barber arrested by ICE | How his immigration story is questioning the system

Rodney Taylor, a Georgia barber, has been pursuing permanent residency for years. Now, he faces deportation to Liberia despite being in the U.S. since childhood.

www.11alive.com

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