Yan CHEN
@yanchen724.bsky.social
Thanks a lot for your interest in our work!
And there you have it, phase separation can override binding affinity. This is a big dogma challenged, what if standard affinity is not a factor, or at least the only one, to determine protein and nucleic acid distribution in cells?
A study on two synaptic proteins reveals that phase separation-mediated formation of molecular condensates and network complexity within condensates can change the biomolecular interaction specificities of these proteins
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 17, 2025 at 5:34 AM
Thanks a lot for your interest in our work!
Reposted by Yan CHEN
A study on two synaptic proteins reveals that phase separation-mediated formation of molecular condensates and network complexity within condensates can change the biomolecular interaction specificities of these proteins
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Phase separation instead of binding strength determines target specificities of MAGUKs - Nature Chemical Biology
Using two synaptic proteins as examples, Chen et al. reveal that phase-separation-mediated formation of molecular condensates can change the biomolecular interaction specificities; the network complex...
www.nature.com
June 11, 2025 at 7:23 PM
A study on two synaptic proteins reveals that phase separation-mediated formation of molecular condensates and network complexity within condensates can change the biomolecular interaction specificities of these proteins
www.nature.com/articles/s41...
www.nature.com/articles/s41...