Want to thank Ramanujan Hegde, Radu Aricescu, Andrija Sente and Ryan Judy at the MRC-LMB for making this work possible. #Postdoc #MRC-LMB (5/5)

Our study provides a rare glimpse into membrane protein assembly, revealing NACHO as a potential chaperone for pentameric ion channels, maintaining ion channel integrity and function, crucial for efficient signal transmission. (4/5)

Using cryo-EM, we visualized an intermediate assembly structure with NACHO interacting with GABA A receptor subunits. NACHO selectively shields regions prone to misfolding, enhancing stability and guiding the precise arrangement of the receptor’s components. (3/5)

We identify how NACHO interacts with unassembled GABA A receptor α1 subunits, binding at specific sites to shield immature, sensitive surfaces on these proteins as they fold and assembly in the ER. (2/5)

We analyzed more than 500 isolates and uncovered almost a 109 distinct genetic types, highlighting the genetic variation of Klebsiella. This research highlights the urgent need for better solutions—like new polyvalent vaccines—to reduce the burden of these infections—and save more lives. (3/3)

Klebsiella infections are becoming more frequent and severe. Adding to the concern is the increase in carbapenem-resistant Klebsiella strains, which are harder to treat and linked to higher death rates, although resistance alone doesn’t appear to fully explain the trend. (2/3)