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Reposted by Yourong Guo

Lianglong Sun @longonga.bsky.social · Apr 4

Happy to share that our article “Human lifespan changes in the brain’s functional connectome” is now published online at Nature Neuroscience @natureneuro.bsky.social !

Many thanks to all collaborators & data contributors, and the editor team & reviewers!

www.nature.com/articles/s41...

Human lifespan changes in the brain’s functional connectome - Nature Neuroscience

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative...

www.nature.com

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Yourong Guo @yrguo.bsky.social · Mar 9

A huge thanks to all my amazing coauthors, especially @metricsemma.bsky.social 😊
🔗 Read the full paper: www.biorxiv.org/content/10.1... 9/9

Motifs of brain cortical folding from birth to adulthood: structural asymmetry and folding-functional links

Cortical folding of brain is widely regarded as an interplay between genetic programming and biomechanical forces, closely linked to cytoarchitectonic regionalisation. Abnormal folding patterns are fr...

www.biorxiv.org

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Yourong Guo @yrguo.bsky.social · Mar 9

We’ve long sought to understand how genetic and biomechanical forces shape cortical folding, and how that relates to actual functional areas. Hopefully, this work takes a small step toward deeper understanding. 8/9

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Yourong Guo @yrguo.bsky.social · Mar 9

Folding-Function links?
Aligning individual HCP task functional activation maps & multi-modal parcellations (Glasser, M. F. et al) using MSM-HT, we find that better structural alignment did not improve functional overlap. 7/9

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Yourong Guo @yrguo.bsky.social · Mar 9

Cortical folding motifs are heritable.
Using MZ and DZ twins data from the HCP young adults, we found motifs co-occurred more frequently in MZ siblings than DZ across all lobes. 6/9

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Yourong Guo @yrguo.bsky.social · Mar 9

Neonates vs. Adults: What changes?
We observed consistency across both age groups, with neonatal samples showing less variation. However, rightward-asymmetric folding clusters had greater temporal lobe surface area than leftward - reversed in adults. 5/9

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Yourong Guo @yrguo.bsky.social · Mar 9

Greater asymmetry in the temporal lobe.
A higher proportion of temporal lobe clusters were leftward-asymmetric compared to other lobes. These motifs showed more anatomical heterogeneity than rightward ones, including interruptions and branching of the superior temporal sulcus. 4/9

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Yourong Guo @yrguo.bsky.social · Mar 9

Disentangling natural cortical shape variability from clinically relevant features starts with better characterizing its scale across large populations. Here, we introduce MSM-HT to parse cortical folding variability into a representative family of distinct anatomical motifs. 3/9

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Yourong Guo @yrguo.bsky.social · Mar 9

🧠 What shapes cortical folding?
Cortical folding is widely regarded as an interplay between genetic programming and biomechanical forces. Abnormal folding patterns are frequently observed in neurodevelopmental conditions and psychiatric disorders. 2/9

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Yourong Guo @yrguo.bsky.social · Mar 9

I'm very excited to share my PhD work "Motifs of brain cortical folding from birth to adulthood: structural asymmetry and folding-functional links". We identified and characterised the lobe-wise folding patterns using both 1110 young adults (HCP) and 781 term-age neonates (dHCP & BIBS studies). 1/9

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