Yingying Chen
@yyingchenyy.bsky.social
Interesting study. Bowhead whales maintain genome integrity through enhanced DNA repair, supported by high CIRBP expression that promotes efficient double-strand break repair. www.nature.com/articles/s41...
Evidence for improved DNA repair in long-lived bowhead whale - Nature
Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein. &nbs...
www.nature.com
November 4, 2025 at 2:32 AM
Interesting study. Bowhead whales maintain genome integrity through enhanced DNA repair, supported by high CIRBP expression that promotes efficient double-strand break repair. www.nature.com/articles/s41...
Mark this, read later.👀
📣 Don't miss this new Review!
Interplay between RNA-protein interactions and RNA structures in gene regulation
🔓 buff.ly/pu6TpVa
🖊️ @rnaminni.bsky.social
#RBPs #RNA #RNAbiology #RNAbindingproteins #RNAbinding #RNAstructure
Interplay between RNA-protein interactions and RNA structures in gene regulation
🔓 buff.ly/pu6TpVa
🖊️ @rnaminni.bsky.social
#RBPs #RNA #RNAbiology #RNAbindingproteins #RNAbinding #RNAstructure
September 30, 2025 at 5:35 AM
Mark this, read later.👀
New type of self-assembloid? Once again, amazed at how rapidly the field of stem-cell-based embryoid models is developing.
New paper from my lab and @jshendure.bsky.social lab! Led by the brilliant @zukailiu.bsky.social and @cxqiu.bsky.social. We tackled how anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid). (1/n) www.biorxiv.org/content/10.1...
September 27, 2025 at 9:49 AM
New type of self-assembloid? Once again, amazed at how rapidly the field of stem-cell-based embryoid models is developing.
Read later. Many related questions have emerged in my mind, let's wait and see.
📣 New preprint from the lab - Endogenous fluctuations of transcription factor levels shape their occupancy in unexpected ways
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Endogenous variability in transcription factor concentrations shapes their genome-wide occupancy
The control of transcription factor (TF) concentrations is crucial for the precise regulation of gene expression and cell fate decisions during development. Yet, TF concentrations can display substant...
www.biorxiv.org
September 27, 2025 at 9:43 AM
Read later. Many related questions have emerged in my mind, let's wait and see.
Reposted by Yingying Chen
Genomic divergence across the tree of life 🧪🌐https://www.pnas.org/doi/10.1073/pnas.2319389122
Genomic divergence across the tree of life | PNAS
Nucleotide sequence data are being harnessed to identify species, even in cases in
which organisms themselves are neither in hand nor witnessed. Bu...
www.pnas.org
September 27, 2025 at 9:21 AM
Genomic divergence across the tree of life 🧪🌐https://www.pnas.org/doi/10.1073/pnas.2319389122
Reposted by Yingying Chen
Congrats to Aurelie Hinterman aurhin.bsky.social, Chase Bolt chasebolt.bsky.social, and Brent Hawkins @homeobox.bsky.social!
Coverage in NYTimes by @carlzimmer.com: www.nytimes.com/2025/09/17/s...
Coverage in NYTimes by @carlzimmer.com: www.nytimes.com/2025/09/17/s...
September 17, 2025 at 5:35 PM
Congrats to Aurelie Hinterman aurhin.bsky.social, Chase Bolt chasebolt.bsky.social, and Brent Hawkins @homeobox.bsky.social!
Coverage in NYTimes by @carlzimmer.com: www.nytimes.com/2025/09/17/s...
Coverage in NYTimes by @carlzimmer.com: www.nytimes.com/2025/09/17/s...
Reposted by Yingying Chen
How can we engineer B cells to treat diseases? Read about the latest developments of this exciting field in this new Review out now in @natbiotech.nature.com www.nature.com/articles/s41...
Engineering B cells to treat and study human disease - Nature Biotechnology
Recent developments in B cell engineering expand our ability to study human disease and drive progress toward new B cell therapies, balancing challenges in clinical implementation with emerging opport...
www.nature.com
August 6, 2025 at 7:55 AM
How can we engineer B cells to treat diseases? Read about the latest developments of this exciting field in this new Review out now in @natbiotech.nature.com www.nature.com/articles/s41...
Unraveling this enhancer's role in mouse embryo development was a journey of trials and awe. DevBio is full of mysteries waiting to be explored--nothing brings me more joy than diving into these questions! 🤩
p-Enh story finally out today! We found a key enhancer in Cdx2 driving posterior tissue development in mouse embryos via the balancing mechanism (in cis & in trans). #DevBio #ILoveBio
Thrilled to share our most recent work concerning the mechanistic study of developmental enhancers. Cis or trans may be a spatial-temporal choice 😁😁😁
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
June 30, 2025 at 12:08 PM
Unraveling this enhancer's role in mouse embryo development was a journey of trials and awe. DevBio is full of mysteries waiting to be explored--nothing brings me more joy than diving into these questions! 🤩
p-Enh story finally out today! We found a key enhancer in Cdx2 driving posterior tissue development in mouse embryos via the balancing mechanism (in cis & in trans). #DevBio #ILoveBio
Thrilled to share our most recent work concerning the mechanistic study of developmental enhancers. Cis or trans may be a spatial-temporal choice 😁😁😁
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Gastrula‐Premarked Posterior Enhancer Primes Posterior Tissue Development Through Cross‐Talk with TGF‐β Signaling Pathway
A gastrula-premarked enhancer within the first intron of Cdx2 governs posterior embryonic development via both regulating Cdx2 expression in cis and coordinating TGF-β signaling in trans to ensure pr...
advanced.onlinelibrary.wiley.com
June 30, 2025 at 12:07 PM