Human myelinated brain organoids with integrated microglia can be used to investigate demyelination, remyelination, and remyelinating therapies
www.science.org/doi/10.1126/...

Finally, Lack of recovery might be due to the fundamental differences between MS and EAE. This study highlights the need for better preclinical models representing PMS.

Others show ABT-263 improves clinical score, but unclear why it is more effective than DQ. One possibility is that the therapeutic effectiveness of senolytics depends on cell type or pathways targeted, and not all senolytics are equally effective at inducing senolysis.

Previous work from lab show DQ was more effective in enhancing remyelination in young vs aged mice, suggesting other inflammatory factors may be inhibiting remyelination. So ongoing inflammatory environment observed in EAE,much like aged tissue may limit DQ therapeutic efficacy.

We show SC myeloid cells accumulate in spinal cord lesions and leptomeningeal compartment following EAE. We also show senescence gene signature increases w disease progression. However, SC reduction does not improve EAE outcome. Few important conclusions made from this work:

Happy to see my work published in Journal of Neuroinflammation! Thanks to my amazing mentor @jkhuang.bsky.social and all the co-authors George Melchor, Meghan Bullard, @philgrossphd.bsky.social for their continued help and support. jneuroinflammation.biomedcentral.com/articles/10....

Very happy to share that Zeeba @zeebamehrin.bsky.social's work on cellular senescence in EAE is now published in J Neuroinflammation! Congratulations, Zeeba, on this informative study! 😀https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-025-03425-3

Please join the 170 MS Activists visiting Capitol Hill this week by sending Congress a message today urging support for funding medical research through the MS Research Program (MSRP) at the Congressionally Directed Medical Research Program (CDMRP) and the NIH. ACT NOW
nmss.quorum.us/campaign/PPC...

Excited to finally have this published! Out today in @naturecomms.bsky.social, we show that following demyelination in a mouse model of Multiple Sclerosis, treatment of senescent microglia with senolytics leads to improved remyelination. www.nature.com/articles/s41...

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I’m happy to share a free new resource to explore published single cell transcriptomic datasets from the Sanofi Rare and Neurologic Diseases Therapeutic Area.

talk2data.bioturing.com/sanofibrowser

If you are worried about science there IS something that you can do! Join us next Friday in DC to make your voice heard. Come and stand up for science! Show that science is for everyone. I’ll be there and I can’t wait to see you there too!
@standupforscience.bsky.social

“There’s going to be a missing age class of researchers that will reverberate for years.” scim.ag/3ERRLDo

Stand Up for Science rallies will be held in DC and state capitals on March 7th. Share with friends. Sign-up here to get email updates with details: www.eventbrite.com/e/stand-up-f...

It is indeed my understanding that most research institutions won't survive if this is implemented. I know I will contact my congress and senate members.

5calls.org

Top 4 things to know about doing science:
1. You need to have someone you can talk to
2. One-on-one discussions are the best
3. Think about discussions as improvisations and use the ‘yes, and’ rule
4. Create a safe space so both of you feel open to saying seemingly silly things

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing 🧠 🕙

Incredible study 🧪 in Nature from @brunetlab.bsky.social and the Zou lab 🎉

So many intriguing findings - including that T cells have a pro-ageing proximity effect on neighbouring cells 🤯

@natureportfolio.bsky.social

Dissecting the evolving cellular landscape of a remyelinating microenvironment https://www.biorxiv.org/content/10.1101/2024.12.25.630253v1