This study introduces single-cell transcription factor (TF) sequencing, a single-cell barcoded and doxycycline-inducible TF overexpression approach that reveals dose-sensitive functional classes of TFs and cellular heterogeneity by mapping TF dose-dependent transcriptomic changes during the reprogramming of mouse embryonic multipotent stromal cells.

Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...

When genetic interactions matter and when they don't

A novel multistep strategy reveals how parent-of-origin effects shape complex traits in large-scale biobanks.

Traits such as height, metabolism, and disease risk can be affected differently – and even in opposite directions – depending on whether the genetic variant responsible is inherited from the mothe...

Understanding how genetic influences on complex traits change with age is a fundamental question in genetic epidemiology. Both cross-sectional (between-subject) and longitudinal (within-subject) appro...

Careers 5 Prime Sciences uses insights from human genetics to accelerate drug development and increase return on investment in the life sciences. Using unique datasets and advanced human genetics anal...

FIMM-EMBL Group Leaders in Molecular Medicine