In this week's episode, we discuss a new study in which researchers developed a #BloodVesselOrganoid model from #HutchinsonGilford progeria syndrome-mutant human embryonic stem cells. 🔬

Read the @cp-devcell.bsky.social study: https://bit.ly/44BDMvB
Listen to the episode: https://bit.ly/4q05JW4

Vascularize #hiPSC-derived Retinal #Organoid with dissociated #EndothelialCell + #MuralCell from #BloodVesselOrganoid

Vascularized RO has more mature neurons (TUJ+SMI32+) & mature RGC (SNCG+)

Hi glucose/IL6/TNFα/VEGF to model #DiabeticRetinopathy

#StemCells 2025
academic.oup.com/stmcls/advan...

mESC-derived #BloodVesselOrganoid maturation on #ChickChorioallantoicMembrane

20% vessels covered by SM α-actin+ cells by 11 d on CAM (love to see more arteriovenous markers)
Connected with CAM circulation

Yoh-suke Mukouyama lab #SciRep 2025
www.nature.com/articles/s41...

hESC-derived #BloodVesselOrganoid with dual #EndothelialCell (PECAM1-mRuby3-secNluc) & #SmoothMuscleCell (ACTA2-EGFP) lineage reporters

For high-throughput screening

#Angiogenesis 2025
link.springer.com/article/10.1...

Viscoelastic Matrix (Gelatin + acryloyl 𝛽-cyclodextrin) favors an Arteriolar phenotype of Endothelial+Mural cells in hiPSC- #BloodVesselOrganoid

scRNAseq▶️
⏬Pericyte
⏫SMC
⏫Mesenchymal EC
⏫Fibroblast

Transplant of such BVOs repair🐭infarcted🫀

Adv Mater 2024
onlinelibrary.wiley.com/doi/abs/10.1...