Human Oncogene EWS::FLI1 Functions as a Pioneer Factor in Saccharomyces cerevisiae. https://www.biorxiv.org/content/10.1101/2025.10.22.680884v1
October 23, 2025 at 7:49 PM
Human Oncogene EWS::FLI1 Functions as a Pioneer Factor in Saccharomyces cerevisiae. https://www.biorxiv.org/content/10.1101/2025.10.22.680884v1
Human Oncogene EWS::FLI1 Functions as a Pioneer Factor in Saccharomyces cerevisiae. https://www.biorxiv.org/content/10.1101/2025.10.22.680884v1
October 23, 2025 at 7:49 PM
Human Oncogene EWS::FLI1 Functions as a Pioneer Factor in Saccharomyces cerevisiae. https://www.biorxiv.org/content/10.1101/2025.10.22.680884v1
Fantastic talk by Prof Alan D’Andrea (Dana-Farber Cancer Institute, Harvard Medical School) showing how the EWS-FLI1 fusion disrupts POLQ splicing and impairs the MMEJ DNA repair pathway in Ewing sarcoma @Australian Cell Cycle, DNA Repair, and Telomere Meeting 2025 #ACDTM25#CancerResearch
October 20, 2025 at 1:23 AM
Fantastic talk by Prof Alan D’Andrea (Dana-Farber Cancer Institute, Harvard Medical School) showing how the EWS-FLI1 fusion disrupts POLQ splicing and impairs the MMEJ DNA repair pathway in Ewing sarcoma @Australian Cell Cycle, DNA Repair, and Telomere Meeting 2025 #ACDTM25#CancerResearch
CK2 inhibitor CX-4945 targets EWS-FLI1 protein abundance and shows anti-tumor activity in metastatic mouse models of Ewing Sarcoma https://www.biorxiv.org/content/10.1101/2025.09.24.677357v1
September 26, 2025 at 11:48 PM
CK2 inhibitor CX-4945 targets EWS-FLI1 protein abundance and shows anti-tumor activity in metastatic mouse models of Ewing Sarcoma https://www.biorxiv.org/content/10.1101/2025.09.24.677357v1
CK2 inhibitor CX-4945 targets EWS-FLI1 protein abundance and shows anti-tumor activity in metastatic mouse models of Ewing Sarcoma https://www.biorxiv.org/content/10.1101/2025.09.24.677357v1
September 26, 2025 at 11:48 PM
CK2 inhibitor CX-4945 targets EWS-FLI1 protein abundance and shows anti-tumor activity in metastatic mouse models of Ewing Sarcoma https://www.biorxiv.org/content/10.1101/2025.09.24.677357v1
Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma. [updated]
EWS::FLI1 fusions drive transcription. Single-cell analysis links gene modules to tumor heterogeneity.
EWS::FLI1 fusions drive transcription. Single-cell analysis links gene modules to tumor heterogeneity.
September 3, 2025 at 8:50 AM
Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma. [updated]
EWS::FLI1 fusions drive transcription. Single-cell analysis links gene modules to tumor heterogeneity.
EWS::FLI1 fusions drive transcription. Single-cell analysis links gene modules to tumor heterogeneity.
EWS::FLI1-DHX9 interaction promotes Ewing #sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism
www.nature.com/articles/s41...
www.nature.com/articles/s41...
EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism - Oncogene
Oncogene - EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism
www.nature.com
July 29, 2025 at 11:47 AM
EWS::FLI1-DHX9 interaction promotes Ewing #sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism
www.nature.com/articles/s41...
www.nature.com/articles/s41...
👉EWS::FLI1 modulates R-loop metabolism via DHX9, driving increased vulnerability to TOP1-targeting agents.
👉Targeting TOP1 in EWS cells destabilizes the genome and provokes strong replication stress and cell death in EwS cells and tumors
Grateful to all collaborators who made this work possible!
👉Targeting TOP1 in EWS cells destabilizes the genome and provokes strong replication stress and cell death in EwS cells and tumors
Grateful to all collaborators who made this work possible!
July 29, 2025 at 8:36 AM
👉EWS::FLI1 modulates R-loop metabolism via DHX9, driving increased vulnerability to TOP1-targeting agents.
👉Targeting TOP1 in EWS cells destabilizes the genome and provokes strong replication stress and cell death in EwS cells and tumors
Grateful to all collaborators who made this work possible!
👉Targeting TOP1 in EWS cells destabilizes the genome and provokes strong replication stress and cell death in EwS cells and tumors
Grateful to all collaborators who made this work possible!
Today at #AACR2025: Our collaborators at CCRI present new cancer research using the OrganoPlate®.
🗓️ April 29 | 9–12
📍 Tumor Biology | PO.TB09.03
🎙️ EWS::FLI1 & Tumor Plasticity in Ewing Sarcoma
Presented by Veveeyan Suresh!
www.mimetas.com/en/cancer-dr...
#EwingSarcoma #CancerResearch #TumorBiology
🗓️ April 29 | 9–12
📍 Tumor Biology | PO.TB09.03
🎙️ EWS::FLI1 & Tumor Plasticity in Ewing Sarcoma
Presented by Veveeyan Suresh!
www.mimetas.com/en/cancer-dr...
#EwingSarcoma #CancerResearch #TumorBiology
April 29, 2025 at 11:45 AM
Today at #AACR2025: Our collaborators at CCRI present new cancer research using the OrganoPlate®.
🗓️ April 29 | 9–12
📍 Tumor Biology | PO.TB09.03
🎙️ EWS::FLI1 & Tumor Plasticity in Ewing Sarcoma
Presented by Veveeyan Suresh!
www.mimetas.com/en/cancer-dr...
#EwingSarcoma #CancerResearch #TumorBiology
🗓️ April 29 | 9–12
📍 Tumor Biology | PO.TB09.03
🎙️ EWS::FLI1 & Tumor Plasticity in Ewing Sarcoma
Presented by Veveeyan Suresh!
www.mimetas.com/en/cancer-dr...
#EwingSarcoma #CancerResearch #TumorBiology
Dynamic modelling of EWS::FLI1 fluctuations reveals molecular determinants of phenotypic tumor plasticity and prognosis in Ewing sarcoma https://www.biorxiv.org/content/10.1101/2025.04.03.647002v1
April 9, 2025 at 3:49 AM
Dynamic modelling of EWS::FLI1 fluctuations reveals molecular determinants of phenotypic tumor plasticity and prognosis in Ewing sarcoma https://www.biorxiv.org/content/10.1101/2025.04.03.647002v1
Dynamic modelling of EWS::FLI1 fluctuations reveals molecular determinants of phenotypic tumor plasticity and prognosis in Ewing sarcoma https://www.biorxiv.org/content/10.1101/2025.04.03.647002v1
April 9, 2025 at 3:49 AM
Dynamic modelling of EWS::FLI1 fluctuations reveals molecular determinants of phenotypic tumor plasticity and prognosis in Ewing sarcoma https://www.biorxiv.org/content/10.1101/2025.04.03.647002v1
RRID:Addgene_12259 was used by the authors of the Cell Reports paper "YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1-mediated reprogramming of bone mesenchymal stem cells". RRIDs like this improve reproducibility in scientific research. #reproducibility
doi.org
April 3, 2025 at 7:00 AM
RRID:Addgene_12259 was used by the authors of the Cell Reports paper "YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1-mediated reprogramming of bone mesenchymal stem cells". RRIDs like this improve reproducibility in scientific research. #reproducibility
Preprint out of induced proximity between EWS/FLI1 with BCL6 leads to cell death by a new TCIP called EB-TCIP. Work out from teams at Stanford and DFCI and co-led by the lab of Kimberly Stegmaier!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Rewiring the fusion oncoprotein EWS/FLI1 in Ewing sarcoma with bivalent small molecules
Deregulated transcription is a defining hallmark of cancer, especially pediatric malignancies, which are frequently driven by fusion transcription factors. Targeting transcription factors directly has...
www.biorxiv.org
March 22, 2025 at 8:10 PM
Preprint out of induced proximity between EWS/FLI1 with BCL6 leads to cell death by a new TCIP called EB-TCIP. Work out from teams at Stanford and DFCI and co-led by the lab of Kimberly Stegmaier!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Rewiring the fusion oncoprotein EWS/FLI1 in Ewing sarcoma with bivalent small molecules https://www.biorxiv.org/content/10.1101/2025.03.14.643353v1
March 17, 2025 at 7:50 PM
Rewiring the fusion oncoprotein EWS/FLI1 in Ewing sarcoma with bivalent small molecules https://www.biorxiv.org/content/10.1101/2025.03.14.643353v1
Rewiring the fusion oncoprotein EWS/FLI1 in Ewing sarcoma with bivalent small molecules https://www.biorxiv.org/content/10.1101/2025.03.14.643353v1
March 17, 2025 at 7:50 PM
Rewiring the fusion oncoprotein EWS/FLI1 in Ewing sarcoma with bivalent small molecules https://www.biorxiv.org/content/10.1101/2025.03.14.643353v1
YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1-mediated reprogramming of bone mesenchymal stem cells
YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1-mediated reprogramming of bone mesenchymal stem cells
Ewing sarcoma incidence follows IGF-1 serum levels during human development. Noorizadeh et al. report that low IGF-1 thresholds sustain viability of EWS::FLI1-mutant embryonal bone mesenchymal stem cell-like cells, but exposure to pubertal IGF-1 levels…
dlvr.it
March 14, 2025 at 2:38 PM
YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1-mediated reprogramming of bone mesenchymal stem cells
Very pleased to share our last collaborative publication with Child team #CRCI2NA @inserm.fr @insermgrandouest.bsky.social #cancéropole_Grand_Ouest #Ewing_sarcoma #KCNA2 #Kv1.2 #EWS::FLI1 #YAP/Hippo
biosignaling.biomedcentral.com/articles/10....
biosignaling.biomedcentral.com/articles/10....
Transcriptional regulation of KCNA2 coding Kv1.2 by EWS::FLI1: involvement in controlling the YAP/Hippo signalling pathway and cell proliferation - Cell Communication and Signaling
Background Ewing sarcoma (ES), the second main pediatric bone sarcoma, is characterised by a chromosomal translocation leading to the formation of fusion proteins like EWS::FLI1. While several studies...
biosignaling.biomedcentral.com
February 19, 2025 at 9:15 AM
Very pleased to share our last collaborative publication with Child team #CRCI2NA @inserm.fr @insermgrandouest.bsky.social #cancéropole_Grand_Ouest #Ewing_sarcoma #KCNA2 #Kv1.2 #EWS::FLI1 #YAP/Hippo
biosignaling.biomedcentral.com/articles/10....
biosignaling.biomedcentral.com/articles/10....
New publication "Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling" @natureportfolio.bsky.social fruitful collaborative project with CRCI2NA @insermgrandouest.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling - Oncogene
Oncogene - Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling
www.nature.com
January 20, 2025 at 2:48 PM
New publication "Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling" @natureportfolio.bsky.social fruitful collaborative project with CRCI2NA @insermgrandouest.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
EWS-FLI1 Expression in Human Embryonic MSCs Leads to Transcriptional Reprograming, Defective DNA Damage Repair and Ewing Sarcoma https://www.biorxiv.org/content/10.1101/2025.01.13.632712v1
January 15, 2025 at 6:27 PM
EWS-FLI1 Expression in Human Embryonic MSCs Leads to Transcriptional Reprograming, Defective DNA Damage Repair and Ewing Sarcoma https://www.biorxiv.org/content/10.1101/2025.01.13.632712v1
EWS-FLI1 Expression in Human Embryonic MSCs Leads to Transcriptional Reprograming, Defective DNA Damage Repair and Ewing Sarcoma https://www.biorxiv.org/content/10.1101/2025.01.13.632712v1
January 15, 2025 at 6:27 PM
EWS-FLI1 Expression in Human Embryonic MSCs Leads to Transcriptional Reprograming, Defective DNA Damage Repair and Ewing Sarcoma https://www.biorxiv.org/content/10.1101/2025.01.13.632712v1
YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1 mediated reprogramming of bone mesenchymal stem cells https://www.biorxiv.org/content/10.1101/2024.07.15.603565v1
YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1 mediated reprogramming of bone mesenchymal stem cells https://www.biorxiv.org/content/10.1101/2024.07.15.603565v1
Ewing sarcoma (EwS) is an aggressive cancer of adolescents in need of effective treatments. Insulin
www.biorxiv.org
July 18, 2024 at 9:48 PM
YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1 mediated reprogramming of bone mesenchymal stem cells https://www.biorxiv.org/content/10.1101/2024.07.15.603565v1
YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1 mediated reprogramming of bone mesenchymal stem cells https://www.biorxiv.org/content/10.1101/2024.07.15.603565v1
YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1 mediated reprogramming of bone mesenchymal stem cells https://www.biorxiv.org/content/10.1101/2024.07.15.603565v1
Ewing sarcoma (EwS) is an aggressive cancer of adolescents in need of effective treatments. Insulin
www.biorxiv.org
July 18, 2024 at 9:48 PM
YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1 mediated reprogramming of bone mesenchymal stem cells https://www.biorxiv.org/content/10.1101/2024.07.15.603565v1
An EWS::FLI1 monoclonal antibody with multimodal utility and specificity for FLI1 https://www.biorxiv.org/content/10.1101/2023.11.13.566886v1
An EWS::FLI1 monoclonal antibody with multimodal utility and specificity for FLI1 https://www.biorxiv.org/content/10.1101/2023.11.13.566886v1
Ewing sarcoma (ES) is a rare tumor that affects children, adolescents, and young adults. This tumor
www.biorxiv.org
November 14, 2023 at 2:23 AM
An EWS::FLI1 monoclonal antibody with multimodal utility and specificity for FLI1 https://www.biorxiv.org/content/10.1101/2023.11.13.566886v1
An EWS::FLI1 monoclonal antibody with multimodal utility and specificity for FLI1 https://www.biorxiv.org/content/10.1101/2023.11.13.566886v1
An EWS::FLI1 monoclonal antibody with multimodal utility and specificity for FLI1 https://www.biorxiv.org/content/10.1101/2023.11.13.566886v1
Ewing sarcoma (ES) is a rare tumor that affects children, adolescents, and young adults. This tumor
www.biorxiv.org
November 14, 2023 at 2:23 AM
An EWS::FLI1 monoclonal antibody with multimodal utility and specificity for FLI1 https://www.biorxiv.org/content/10.1101/2023.11.13.566886v1