🩻 Case Study of the Week - Diagnosis time!
Hepatoblastoma (HB)
Learn more 🔗 bit.ly/4pGcxaV
#Radiology #RadEd #MedEd #RadiologyEducation #COW #CaseOfTheWeek #PediatricRadiology
Hepatoblastoma (HB)
Learn more 🔗 bit.ly/4pGcxaV
#Radiology #RadEd #MedEd #RadiologyEducation #COW #CaseOfTheWeek #PediatricRadiology
January 30, 2026 at 12:25 PM
🩻 Case Study of the Week - Diagnosis time!
Hepatoblastoma (HB)
Learn more 🔗 bit.ly/4pGcxaV
#Radiology #RadEd #MedEd #RadiologyEducation #COW #CaseOfTheWeek #PediatricRadiology
Hepatoblastoma (HB)
Learn more 🔗 bit.ly/4pGcxaV
#Radiology #RadEd #MedEd #RadiologyEducation #COW #CaseOfTheWeek #PediatricRadiology
Definitely.
HHS is doing a "softer" study in the U.S. by removing the recommendation for neonatal hepatitis B vaccination.
At least here parents can still opt for it.
But misinformation is powerful.
We will see more young Americans with chronic Hep B, cirrhosis, and hepatoblastoma.
HHS is doing a "softer" study in the U.S. by removing the recommendation for neonatal hepatitis B vaccination.
At least here parents can still opt for it.
But misinformation is powerful.
We will see more young Americans with chronic Hep B, cirrhosis, and hepatoblastoma.
January 24, 2026 at 8:35 PM
Definitely.
HHS is doing a "softer" study in the U.S. by removing the recommendation for neonatal hepatitis B vaccination.
At least here parents can still opt for it.
But misinformation is powerful.
We will see more young Americans with chronic Hep B, cirrhosis, and hepatoblastoma.
HHS is doing a "softer" study in the U.S. by removing the recommendation for neonatal hepatitis B vaccination.
At least here parents can still opt for it.
But misinformation is powerful.
We will see more young Americans with chronic Hep B, cirrhosis, and hepatoblastoma.
Grandma of a survivor of pediatric cancer here (dx w/hepatoblastoma at nine months, now a healthy and beautiful age eleven).
So I had to repost.
So I had to repost.
I have been feeling a lot of anger lately due to our political climate.
Dolly made this video today for her 80th birthday to benefit pediatric cancer.
We can’t lose hope.
youtu.be/McaD2PG8jOE
Dolly made this video today for her 80th birthday to benefit pediatric cancer.
We can’t lose hope.
youtu.be/McaD2PG8jOE
Dolly Parton - Light of a Clear Blue Morning ft. Lainey Wilson, Miley Cyrus, Queen Latifah & Reba
YouTube video by Dolly Parton
youtu.be
January 18, 2026 at 3:28 AM
Grandma of a survivor of pediatric cancer here (dx w/hepatoblastoma at nine months, now a healthy and beautiful age eleven).
So I had to repost.
So I had to repost.
The complex interplay between genetic alterations, chromosomal instability and epigenetic dysregulation in #hepatoblastoma development reflects the inherent complexity in hepatoblastoma oncogenesis http://dlvr.it/TQP4zp
January 16, 2026 at 10:15 PM
The complex interplay between genetic alterations, chromosomal instability and epigenetic dysregulation in #hepatoblastoma development reflects the inherent complexity in hepatoblastoma oncogenesis http://dlvr.it/TQP4zp
Now back to treating young adults for hepatoblastoma, acquired through Hep B infection at birth or in early infancy.
January 7, 2026 at 11:29 PM
Now back to treating young adults for hepatoblastoma, acquired through Hep B infection at birth or in early infancy.
In regard to the Hep B vaccine changes, I've cared for young adults with hepatoblastoma who undoubtedly acquired Hepatitis B at birth.
It's a very difficult malignancy to treat.
It's a very difficult malignancy to treat.
January 6, 2026 at 4:32 AM
In regard to the Hep B vaccine changes, I've cared for young adults with hepatoblastoma who undoubtedly acquired Hepatitis B at birth.
It's a very difficult malignancy to treat.
It's a very difficult malignancy to treat.
Happy to share our recent work.
Targeting ATR to overcome cisplatin resistance in hepatoblastoma - Journal of Hepatology www.journal-of-hepatology.eu/article/S016...
Targeting ATR to overcome cisplatin resistance in hepatoblastoma - Journal of Hepatology www.journal-of-hepatology.eu/article/S016...
Targeting ATR to overcome cisplatin resistance in hepatoblastoma
Hepatoblastoma (HB) is the most common pediatric liver cancer. While standard cisplatin-based
therapy cures ∼80% of patients, resistance remains a major challenge, with no standard
second-line treatme...
www.journal-of-hepatology.eu
December 20, 2025 at 4:54 PM
Happy to share our recent work.
Targeting ATR to overcome cisplatin resistance in hepatoblastoma - Journal of Hepatology www.journal-of-hepatology.eu/article/S016...
Targeting ATR to overcome cisplatin resistance in hepatoblastoma - Journal of Hepatology www.journal-of-hepatology.eu/article/S016...
Our study on “Surgical Outcomes of Liver Resection for Hepatoblastoma in Infants Versus Older Children: A Bi-Centric, Propensity-Score-Matched, Comparative Study” has just been published in the journal of pediatric surgery.
www.jpedsurg.org/article/S002...
#medsky #pedsky #surgsky
www.jpedsurg.org/article/S002...
#medsky #pedsky #surgsky
Surgical Outcomes of Liver Resection for Hepatoblastoma in Infants Versus Older Children: A Bi-Centric, Propensity-Score-Matched, Comparative Study
Hepatoblastoma (HB) is the most common pediatric liver malignancy, with most patients
undergoing surgical resection after neoadjuvant chemotherapy at an age older than
one year. Infants (≤12 months) u...
www.jpedsurg.org
November 22, 2025 at 6:24 PM
Our study on “Surgical Outcomes of Liver Resection for Hepatoblastoma in Infants Versus Older Children: A Bi-Centric, Propensity-Score-Matched, Comparative Study” has just been published in the journal of pediatric surgery.
www.jpedsurg.org/article/S002...
#medsky #pedsky #surgsky
www.jpedsurg.org/article/S002...
#medsky #pedsky #surgsky
And this feature of how Wnt/β-catenin seems to be universal - not only in hepatoblastoma 👇
November 10, 2025 at 10:04 AM
And this feature of how Wnt/β-catenin seems to be universal - not only in hepatoblastoma 👇
In Hepatoblastoma two subtypes coexist, the fetal (F) more liver-like, and the embryonal (E), less dedifferentiated and more aggressive
In both there is constitutively active β-catenin
How does E cells express more classical #Wnt target genes?
In both there is constitutively active β-catenin
How does E cells express more classical #Wnt target genes?
November 10, 2025 at 10:04 AM
In Hepatoblastoma two subtypes coexist, the fetal (F) more liver-like, and the embryonal (E), less dedifferentiated and more aggressive
In both there is constitutively active β-catenin
How does E cells express more classical #Wnt target genes?
In both there is constitutively active β-catenin
How does E cells express more classical #Wnt target genes?
In one tumor, despite the shared oncogenic driver mutations, there may be different cell types
In collaboration with the Peng Lab we used Hepatoblastoma to investigate this.
Our results show that β-catenin can drive different transcriptional programs across cancer cell populations
Check this out👇
In collaboration with the Peng Lab we used Hepatoblastoma to investigate this.
Our results show that β-catenin can drive different transcriptional programs across cancer cell populations
Check this out👇
Differential Wnt/β-Catenin Signaling via TCF7L2/LEF1 Binding Specificity Shapes Cellular and Tumor Phenotypes https://www.biorxiv.org/content/10.1101/2025.11.04.686471v1
November 10, 2025 at 10:04 AM
In one tumor, despite the shared oncogenic driver mutations, there may be different cell types
In collaboration with the Peng Lab we used Hepatoblastoma to investigate this.
Our results show that β-catenin can drive different transcriptional programs across cancer cell populations
Check this out👇
In collaboration with the Peng Lab we used Hepatoblastoma to investigate this.
Our results show that β-catenin can drive different transcriptional programs across cancer cell populations
Check this out👇
“Billy fought hepatoblastoma, a rare liver cancer. He faced the hardest battle of his young life until he passed at age 3. Though he isn’t here today, his spirit is alive, and because of your support, we are determined to pay it forward.”
October 15, 2025 at 2:13 PM
“Billy fought hepatoblastoma, a rare liver cancer. He faced the hardest battle of his young life until he passed at age 3. Though he isn’t here today, his spirit is alive, and because of your support, we are determined to pay it forward.”
Hepatoblastoma: www.ctisus.com/teachingfile...
October 10, 2025 at 5:26 PM
Hepatoblastoma: www.ctisus.com/teachingfile...
This case report describes the successful use of trans-arterial radioembolization (TARE-Y90) and bland trans-arterial embolization (TAE) to treat a 12-month-old boy with chemotherapy-resistant, unresectable hepatoblastoma.
October 6, 2025 at 2:49 PM
This case report describes the successful use of trans-arterial radioembolization (TARE-Y90) and bland trans-arterial embolization (TAE) to treat a 12-month-old boy with chemotherapy-resistant, unresectable hepatoblastoma.
Pioneering pediatric case uses innovative embolization techniques to shrink unresectable hepatoblastoma, paving the way for life-saving liver transplant in a high-risk child.
🧵 Thread below
Full analysis: https://helixbrief.com/article/a8383755-6866-49cd-ab90-6ea98cf2b738
🧵 Thread below
Full analysis: https://helixbrief.com/article/a8383755-6866-49cd-ab90-6ea98cf2b738
October 6, 2025 at 2:49 PM
Pioneering pediatric case uses innovative embolization techniques to shrink unresectable hepatoblastoma, paving the way for life-saving liver transplant in a high-risk child.
🧵 Thread below
Full analysis: https://helixbrief.com/article/a8383755-6866-49cd-ab90-6ea98cf2b738
🧵 Thread below
Full analysis: https://helixbrief.com/article/a8383755-6866-49cd-ab90-6ea98cf2b738
Online now: Single-cell profiles delineate immune cell remodeling and enhanced tumor-fibroblast interaction of hepatoblastoma after chemotherapy
Single-cell profiles delineate immune cell remodeling and enhanced tumor-fibroblast interaction of hepatoblastoma after chemotherapy
Chen et al. study pre- and post-chemotherapy hepatoblastoma through scRNA-seq and spatial transcriptomics and discover an activated immune TME with activated cell-cell interactions. They identify enrichment of proliferative hepatic-like cells (HECs) related to chemo-resistance, which interact with CAFs through FGF-FGFR4 pathway, and thus provide insights into FGFR4 targeted therapeutic strategy.
dlvr.it
October 3, 2025 at 12:27 PM
Online now: Single-cell profiles delineate immune cell remodeling and enhanced tumor-fibroblast interaction of hepatoblastoma after chemotherapy
Myeloid Immune Cells: A Promising New Target for Liver Cancer Immunotherapy
In a groundbreaking investigation into pediatric liver cancer, researchers from the Princess Máxima Center and UMC Utrecht have uncovered an unexpected abundance of myeloid immune cells within hepatoblastoma tumors. This…
In a groundbreaking investigation into pediatric liver cancer, researchers from the Princess Máxima Center and UMC Utrecht have uncovered an unexpected abundance of myeloid immune cells within hepatoblastoma tumors. This…
Myeloid Immune Cells: A Promising New Target for Liver Cancer Immunotherapy
In a groundbreaking investigation into pediatric liver cancer, researchers from the Princess Máxima Center and UMC Utrecht have uncovered an unexpected abundance of myeloid immune cells within hepatoblastoma tumors. This revelation challenges previous assumptions about the immunological landscape of these tumors and opens novel pathways for therapeutic intervention, especially in the realm of immunotherapy for children. Hepatoblastoma represents the most prevalent liver malignancy in children, arising when immature hepatic cells arrest in an undifferentiated state and begin unchecked proliferation.
scienmag.com
September 29, 2025 at 4:32 PM
Myeloid Immune Cells: A Promising New Target for Liver Cancer Immunotherapy
In a groundbreaking investigation into pediatric liver cancer, researchers from the Princess Máxima Center and UMC Utrecht have uncovered an unexpected abundance of myeloid immune cells within hepatoblastoma tumors. This…
In a groundbreaking investigation into pediatric liver cancer, researchers from the Princess Máxima Center and UMC Utrecht have uncovered an unexpected abundance of myeloid immune cells within hepatoblastoma tumors. This…
To my fellow Bills fans - if you’re feeling generous this morning, please consider donating to this GoFundMe set up for baby Hazel who is fighting Hepatoblastoma - gofund.me/818f276ad - any amount helps. Thanks!
Donate to Support for Baby Hazel's Fight Against Hepatoblastoma, organized by Debbie Wolfe
Debbie Wolfe is organizing this fundraiser on behalf of Lindsay and… Debbie Wolfe needs your support for Support for Baby Hazel's Fight Against Hepatoblastoma
gofund.me
September 28, 2025 at 3:57 PM
To my fellow Bills fans - if you’re feeling generous this morning, please consider donating to this GoFundMe set up for baby Hazel who is fighting Hepatoblastoma - gofund.me/818f276ad - any amount helps. Thanks!
Beckwith-Wiedemann syndrome multiomic analysis of hepatoblastoma uncovers unique tumor heterogeneity and cellular landscapes, including transition cells leading to tumor formation https://www.biorxiv.org/content/10.1101/2025.09.17.676802v1
September 20, 2025 at 4:50 PM
Beckwith-Wiedemann syndrome multiomic analysis of hepatoblastoma uncovers unique tumor heterogeneity and cellular landscapes, including transition cells leading to tumor formation https://www.biorxiv.org/content/10.1101/2025.09.17.676802v1
Beckwith-Wiedemann syndrome multiomic analysis of hepatoblastoma uncovers unique tumor heterogeneity and cellular landscapes, including transition cells leading to tumor formation https://www.biorxiv.org/content/10.1101/2025.09.17.676802v1
September 20, 2025 at 4:50 PM
Beckwith-Wiedemann syndrome multiomic analysis of hepatoblastoma uncovers unique tumor heterogeneity and cellular landscapes, including transition cells leading to tumor formation https://www.biorxiv.org/content/10.1101/2025.09.17.676802v1
Cassidy needs to tell the country that RFK,Jr. is a clear and present danger to public health or he is an accomplice to future illness and death.
I've treated grown-ups struggling to receive liver transplants and/or battling hepatoblastoma, a condition the vaccine nearly vanquished.
I've treated grown-ups struggling to receive liver transplants and/or battling hepatoblastoma, a condition the vaccine nearly vanquished.
September 17, 2025 at 3:51 AM
Cassidy needs to tell the country that RFK,Jr. is a clear and present danger to public health or he is an accomplice to future illness and death.
I've treated grown-ups struggling to receive liver transplants and/or battling hepatoblastoma, a condition the vaccine nearly vanquished.
I've treated grown-ups struggling to receive liver transplants and/or battling hepatoblastoma, a condition the vaccine nearly vanquished.
Otra Emilia, con un hepatoblastoma infantil (cancer en el hígado) cuenta mi dinero 1513333
September 13, 2025 at 1:55 PM
Otra Emilia, con un hepatoblastoma infantil (cancer en el hígado) cuenta mi dinero 1513333
Targeting LncRNA938/TAF9/TTK Axis Enhances Hepatoblastoma Treatment
In the evolving landscape of cancer research, new and groundbreaking findings continue to emerge, which challenge the boundaries of our understanding of tumor biology. A recent study led by a team of researchers, including Jin,…
In the evolving landscape of cancer research, new and groundbreaking findings continue to emerge, which challenge the boundaries of our understanding of tumor biology. A recent study led by a team of researchers, including Jin,…
Targeting LncRNA938/TAF9/TTK Axis Enhances Hepatoblastoma Treatment
In the evolving landscape of cancer research, new and groundbreaking findings continue to emerge, which challenge the boundaries of our understanding of tumor biology. A recent study led by a team of researchers, including Jin, Dong, and Xie, has shed light on the role of the LncRNA938/TAF9/TTK axis in the process of epithelial-mesenchymal transition (EMT) specifically in hepatoblastoma, a rare but aggressive cancer that primarily affects children.
scienmag.com
September 7, 2025 at 5:13 PM
Targeting LncRNA938/TAF9/TTK Axis Enhances Hepatoblastoma Treatment
In the evolving landscape of cancer research, new and groundbreaking findings continue to emerge, which challenge the boundaries of our understanding of tumor biology. A recent study led by a team of researchers, including Jin,…
In the evolving landscape of cancer research, new and groundbreaking findings continue to emerge, which challenge the boundaries of our understanding of tumor biology. A recent study led by a team of researchers, including Jin,…
Happy to share our contribution to #PediPath. I hope you find it useful! Pathology reporting of hepatoblastoma resections: recommendations from the international collaboration on cancer reporting - López‐Terrada - Histopathology - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...
Pathology reporting of hepatoblastoma resections: recommendations from the international collaboration on cancer reporting
This is the first international dataset for the reporting of hepatoblastoma resection specimens produced by the International Collaboration on Cancer Reporting (ICCR). The aim is to standardize patho...
onlinelibrary.wiley.com
August 20, 2025 at 12:55 PM
Happy to share our contribution to #PediPath. I hope you find it useful! Pathology reporting of hepatoblastoma resections: recommendations from the international collaboration on cancer reporting - López‐Terrada - Histopathology - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...
Hepatoblastoma is different to hepatocellular carcinoma. Cell lines will of course be bad models of a disease. Misidentified cell lines will be even worse. You think it doesn't matter just because they're both from the same organ? Absolutely baffling take from a "cancer biologist".
August 19, 2025 at 11:50 PM
Hepatoblastoma is different to hepatocellular carcinoma. Cell lines will of course be bad models of a disease. Misidentified cell lines will be even worse. You think it doesn't matter just because they're both from the same organ? Absolutely baffling take from a "cancer biologist".