GOOD NEWS! For the first time ever, Huntington's disease has been successfully treated. A groundbreaking new miRNA treatment, AMT-130, slowed the progression of the disease by 75%. These results are likely to support the first approval of a genetic treatment for the rare neurodegenerative condition.
October 19, 2025 at 4:00 PM
Everybody can reply
1.8K reposts
65 quotes
5.6K likes
110 saves
huntingtin gene. If one of your parents has Huntington's disease, there's a 50% chance that you will inherit the altered gene and will eventually develop Huntington's too. This mutation turns a normal protein needed in the brain -called the huntingtin protein- into a killer of neurons.
October 19, 2025 at 4:05 PM
Everybody can reply
6 reposts
110 likes
inactivating the mutant protein that causes Huntington’s. It is delivered to the brain in a single shot during a 12- to 20-hour surgical procedure. A single dose is expected to last for a patient’s lifetime. To break this down: Huntington's disease is caused by an error in part of our DNA called the
October 19, 2025 at 4:05 PM
Everybody can reply
6 reposts
130 likes
Huntington's, HIV, generalized flu vaccines, what other amazing treatments do we have coming down the pipeline?
October 19, 2025 at 4:25 PM
Everybody can reply
35 likes
Huntington’s disease, a devastating degenerative illness that runs in families, has been treated successfully for the first time in a breakthrough gene therapy trial. The disease, caused by a single gene defect, steadily kills brain cells leading to dementia, paralysis and ultimately death.
October 19, 2025 at 4:04 PM
Everybody can reply
12 reposts
170 likes
1 saves
The goal of this treatment is to reduce levels of this toxic protein permanently, in a single dose. The therapy uses cutting edge genetic medicine combining gene therapy and gene silencing technologies. It starts with a safe virus that has been altered to contain a specially designed sequence of
October 19, 2025 at 4:07 PM
Everybody can reply
7 reposts
100 likes
2 saves
Those with a parent with Huntington’s have a 50% chance of developing the disease, which has been incurable, until now that is. The therapy, known as AMT-130, successfully slowed the progress of the disease by 75% in patients after three years in trials. How does it work? AMT-130 works by
October 19, 2025 at 4:05 PM
Everybody can reply
8 reposts
130 likes
if you were considered at risk for Huntington's pre ACA, with a 50/50 chance of getting it, you tried to keep that information out of all your medical files; that's what they're trying to bring back
Before the ACA was passed, my physician told me NOT to get genetic testing. For the cancer that killed my mom.
They told me not to because if I did, I might not be able to get affordable health insurance. Or any health insurance.
They told me not to because if I did, I might not be able to get affordable health insurance. Or any health insurance.
October 20, 2025 at 3:38 PM
Everybody can reply
4 reposts
10 likes
1 saves
Results from the trial have been released in a statement by the company uniQure. The data from the company HAS been shared with independent scientists for review to be published.
• www.bbc.com/news/article...
• www.globenewswire.com/news-release...
🧪🧵⬇️
• www.bbc.com/news/article...
• www.globenewswire.com/news-release...
🧪🧵⬇️
October 19, 2025 at 4:03 PM
Everybody can reply
35 reposts
2 quotes
200 likes
5 saves
Huntington’s is a devastating disease. This is excellent news. A hearty FU to those who are devastating our research capabilities.
GOOD NEWS! For the first time ever, Huntington's disease has been successfully treated. A groundbreaking new miRNA treatment, AMT-130, slowed the progression of the disease by 75%. These results are likely to support the first approval of a genetic treatment for the rare neurodegenerative condition.
October 19, 2025 at 6:03 PM
Everybody can reply
4 reposts
12 likes
October 20, 2025 at 12:28 AM
Everybody can reply
3 reposts
17 likes
To read this a day after hearing a crowd of people singing "This Land is Your Land" by Woody Guthrie, nearly 60 years after his death by Huntington's, makes me more insistent that when this current political class passes, we must restore science funding in full.
October 19, 2025 at 5:26 PM
Everybody can reply
1 reposts
1 quotes
25 likes
I never thought we'd treat Huntington's. Ever. But because we as a species insist on solving mysteries, we keep progressing. We keep moving forward and improving lives. Now more than ever we have to resist attempts to take us back to a time where "type 1 diabetic adults" didn't exist.
October 21, 2025 at 6:21 PM
Everybody can reply
8 likes
oh my god this is AMAZING news. Huntington's Disease is really, really nasty.
GOOD NEWS! For the first time ever, Huntington's disease has been successfully treated. A groundbreaking new miRNA treatment, AMT-130, slowed the progression of the disease by 75%. These results are likely to support the first approval of a genetic treatment for the rare neurodegenerative condition.
October 21, 2025 at 11:34 PM
Everybody can reply
4 reposts
19 likes
Smoking may accelerate Huntington’s disease progression -especially for women.
New research links smoking to earlier symptom onset and faster motor and cognitive decline.
Find out more: www.emjreviews.com/en-us/amj/ne...
New research links smoking to earlier symptom onset and faster motor and cognitive decline.
Find out more: www.emjreviews.com/en-us/amj/ne...
October 20, 2025 at 1:09 PM
Everybody can reply
1 likes
I can't wait to read the results when they get through peer review. I think back to being in Huntington's clinic 15 years ago; this is beyond-wildest-dreams-level stuff
exciting times in genetics, I tell ya
exciting times in genetics, I tell ya
October 19, 2025 at 5:21 PM
Everybody can reply
4 likes
I dislike Huntington's clash of civilizations thesis, but this quote from his 1993 article strikes me as particularly prophetic: "“A Western democrat could carry on an intellectual debate with a Soviet Marxist. It would be virtually impossible for him to do that with a Russian traditionalist. (1)
"
"
October 15, 2025 at 10:52 PM
Everybody can reply
6 reposts
23 likes
4 saves
Cochrane was Huntington’s XO at the Guantanamo landing, among other things.
He accompanied Lincoln to Gettysburg for the cemetery commemoration in 1863, IIRC, and didn’t retire until after the Spanish war.
A real grey-beard…
He accompanied Lincoln to Gettysburg for the cemetery commemoration in 1863, IIRC, and didn’t retire until after the Spanish war.
A real grey-beard…
October 13, 2025 at 4:38 PM
Everybody can reply
2 reposts
12 likes
I have a complex relationship with Squared Circle on reddit. I try to keep them at an arm's distance.
Many people insulted my Family's Huntington's Diesease and mocked me with jokes about it.
So I am very touchy about reddit.
The mods did nothing to stop it, and I have never forgiven them.
Many people insulted my Family's Huntington's Diesease and mocked me with jokes about it.
So I am very touchy about reddit.
The mods did nothing to stop it, and I have never forgiven them.
Someone has posted about my work on reddit. I don't want it to be there. I am deleting all of my posts that get referred to, and will stop discussing this topic until I have more to add.
Sorry. I shouldn't treat this like a chat together. I have to be more mindful.
Sorry. I shouldn't treat this like a chat together. I have to be more mindful.
October 10, 2025 at 7:11 PM
Everybody can reply
39 likes
It's fine. I have a complicated relationship with Squared Circle.
Ever since tons of people piled on me making fun of my family's Huntington's Disease, I have issues with them.
Ever since tons of people piled on me making fun of my family's Huntington's Disease, I have issues with them.
October 10, 2025 at 7:04 PM
Everybody can reply
10 likes
🍃 🧪 New Gene Therapy for Huntington's Disease
AMT-130 slows disease progression by 75%, treatment is still in clinical trials
AMT-130 slows disease progression by 75%, treatment is still in clinical trials
After yrs of disappointment scientists have made a genuine advance in treating Huntington's. The new gene therapy slowed disease progression by 75%. But it's still experimental and will likely be $$, @parshallison.bsky.social reports for @sciam.bsky.social: www.scientificamerican.com/article/firs...
How Scientists Finally Found a Treatment that Slows Huntington’s Disease
After years of heartbreak, researchers have found an experimental treatment that can slow the progression of Huntington’s disease, according to early results from a small clinical trial
www.scientificamerican.com
October 10, 2025 at 12:25 PM
Everybody can reply
1 reposts
9 likes
1 saves
MAYBE Nathan was in a GOO-GEL bath keeping him alive and his cells were being transferred into BRITT to cure her Huntington's. #GH
I don't know
I'm bored
I don't know
I'm bored
October 9, 2025 at 6:25 PM
Everybody can reply
26 likes
5/ For the first time, researchers have slowed Huntington’s disease progression by 75% using new targeted gene therapy delivered during a lengthy brain surgery. It’s a major step forward for patients and families affected by this devastating disease.
👉 bbc.com/news/articles/cevz13xkxpro
👉 bbc.com/news/articles/cevz13xkxpro
October 9, 2025 at 5:55 PM
Everybody can reply
2 reposts
30 likes
“Three years after participants received the treatment, their disease had progressed 75 percent more slowly compared with that the of people in the control group.” #Huntington’s
After yrs of disappointment scientists have made a genuine advance in treating Huntington's. The new gene therapy slowed disease progression by 75%. But it's still experimental and will likely be $$, @parshallison.bsky.social reports for @sciam.bsky.social: www.scientificamerican.com/article/firs...
How Scientists Finally Found a Treatment that Slows Huntington’s Disease
After years of heartbreak, researchers have found an experimental treatment that can slow the progression of Huntington’s disease, according to early results from a small clinical trial
www.scientificamerican.com
October 10, 2025 at 12:47 PM
Everybody can reply
1 likes
For the first time, doctors say Huntington’s disease, one of the most devastating hereditary neurological conditions, has been successfully treated. www.optimistdaily.com/2025/10/hunt...
Huntington’s disease breakthrough: gene therapy slows progression by 75 percent | The Optimist Daily
Doctors report the first successful treatment for Huntington’s disease, slowing its progression by 75 percent and offering new hope for families.
www.optimistdaily.com
October 7, 2025 at 6:35 PM
Everybody can reply
17 reposts
35 likes