Who controls type-2 immunity?
Turns out fibroblasts do , via a C3–IL-33–ILC2 axis that shapes allergic inflammation in vivo. @atakkatan.bsky.social
Our new work highlighted by @cellreports.bsky.social
#Immunology #StromalBiology #Allergy #Asthma #ILC2 #IL33 #Complement
Turns out fibroblasts do , via a C3–IL-33–ILC2 axis that shapes allergic inflammation in vivo. @atakkatan.bsky.social
Our new work highlighted by @cellreports.bsky.social
#Immunology #StromalBiology #Allergy #Asthma #ILC2 #IL33 #Complement
Complement-producing adventitial fibroblasts form an IL-33 alarmin hub that maintains ILC2s during airway allergy
Complement-producing adventitial fibroblasts form an IL-33 alarmin hub that maintains ILC2s during airway allergy
Atakkatan et al. identify a distinct subset of C3+IL-33+ adventitial fibroblasts (AFs) that drives allergic inflammation by maintaining ILC2 responses. In turn, ILC2-derived IL-13 supports AF function, thus engaging in a pro-allergic dialogue that promotes type 2 immunity.
dlvr.it
December 13, 2025 at 4:34 PM
Who controls type-2 immunity?
Turns out fibroblasts do , via a C3–IL-33–ILC2 axis that shapes allergic inflammation in vivo. @atakkatan.bsky.social
Our new work highlighted by @cellreports.bsky.social
#Immunology #StromalBiology #Allergy #Asthma #ILC2 #IL33 #Complement
Turns out fibroblasts do , via a C3–IL-33–ILC2 axis that shapes allergic inflammation in vivo. @atakkatan.bsky.social
Our new work highlighted by @cellreports.bsky.social
#Immunology #StromalBiology #Allergy #Asthma #ILC2 #IL33 #Complement
Our cool new paper depicting fibroblasts more than a scaffold during airway allergy. #Il33 #ILC2 #complement
New paper alert! We show essential role of #fibroblasts derived #complement C3 in maintaining #Il33-#ILC2 hub during airway #allergy. Congratulations to hard working Ph.D. Students @atakkatan.bsky.social @aishwaryamagesh.bsky.social www.cell.com/cell-reports... @johnshopkinsmmi.bsky.social
Complement-producing adventitial fibroblasts form an IL-33 alarmin hub that maintains ILC2s during airway allergy
Atakkatan et al. identify a distinct subset of C3+IL-33+ adventitial fibroblasts (AFs)
that drives allergic inflammation by maintaining ILC2 responses. In turn, ILC2-derived
IL-13 supports AF function...
www.cell.com
December 3, 2025 at 1:34 AM
Our cool new paper depicting fibroblasts more than a scaffold during airway allergy. #Il33 #ILC2 #complement
Thrilled to share our work that has indeed *complemented* ongoing research in the lab!!!🙌
#complement #IL33 #fibroblast #ILC2 #airwayallergy
#complement #IL33 #fibroblast #ILC2 #airwayallergy
New paper alert! We show essential role of #fibroblasts derived #complement C3 in maintaining #Il33-#ILC2 hub during airway #allergy. Congratulations to hard working Ph.D. Students @atakkatan.bsky.social @aishwaryamagesh.bsky.social www.cell.com/cell-reports... @johnshopkinsmmi.bsky.social
Complement-producing adventitial fibroblasts form an IL-33 alarmin hub that maintains ILC2s during airway allergy
Atakkatan et al. identify a distinct subset of C3+IL-33+ adventitial fibroblasts (AFs)
that drives allergic inflammation by maintaining ILC2 responses. In turn, ILC2-derived
IL-13 supports AF function...
www.cell.com
December 3, 2025 at 2:09 AM
Thrilled to share our work that has indeed *complemented* ongoing research in the lab!!!🙌
#complement #IL33 #fibroblast #ILC2 #airwayallergy
#complement #IL33 #fibroblast #ILC2 #airwayallergy
#LocationLocationLocation! Wang Eisenstein Waizman @yaleschoolofmed.bsky.social &co show @ Science Immunology that physical, chemical, & radiation skin damage induces IL33 activating ILC2 & transferring to distal barrier tissues the capacity to induce antibodies causing #allergic responses!
Skin damage signals mediate allergic sensitization to spatially unlinked antigen
Skin injury releases damage-encoded systemic signals that can initiate immunity to novel antigens introduced at distal barrier sites.
www.science.org
April 4, 2025 at 8:06 PM
#LocationLocationLocation! Wang Eisenstein Waizman @yaleschoolofmed.bsky.social &co show @ Science Immunology that physical, chemical, & radiation skin damage induces IL33 activating ILC2 & transferring to distal barrier tissues the capacity to induce antibodies causing #allergic responses!
Featured today by @MSKLibrary: IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer
#IL33 #ILC2 #TertiaryLymphoidStructures #PancreaticCancer #CancerImmunology
www.nature.com/articles/s41...
#IL33 #ILC2 #TertiaryLymphoidStructures #PancreaticCancer #CancerImmunology
www.nature.com/articles/s41...
March 7, 2025 at 4:31 PM
Featured today by @MSKLibrary: IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer
#IL33 #ILC2 #TertiaryLymphoidStructures #PancreaticCancer #CancerImmunology
www.nature.com/articles/s41...
#IL33 #ILC2 #TertiaryLymphoidStructures #PancreaticCancer #CancerImmunology
www.nature.com/articles/s41...
New paper alert! We show essential role of #fibroblasts derived #complement C3 in maintaining #Il33-#ILC2 hub during airway #allergy. Congratulations to hard working Ph.D. Students @atakkatan.bsky.social @aishwaryamagesh.bsky.social www.cell.com/cell-reports... @johnshopkinsmmi.bsky.social
Complement-producing adventitial fibroblasts form an IL-33 alarmin hub that maintains ILC2s during airway allergy
Atakkatan et al. identify a distinct subset of C3+IL-33+ adventitial fibroblasts (AFs)
that drives allergic inflammation by maintaining ILC2 responses. In turn, ILC2-derived
IL-13 supports AF function...
www.cell.com
December 3, 2025 at 1:29 AM
New paper alert! We show essential role of #fibroblasts derived #complement C3 in maintaining #Il33-#ILC2 hub during airway #allergy. Congratulations to hard working Ph.D. Students @atakkatan.bsky.social @aishwaryamagesh.bsky.social www.cell.com/cell-reports... @johnshopkinsmmi.bsky.social