Congratulations to @Tush96rkhane on being awarded the DBT-CTEP travel support grant for attending #MBIMPG2025 @MBIsg. We are thrilled by his progress and future plans. Way to go Tushar !
buff.ly/epdJ298
buff.ly/epdJ298
September 17, 2025 at 6:40 AM
Congratulations to @Tush96rkhane on being awarded the DBT-CTEP travel support grant for attending #MBIMPG2025 @MBIsg. We are thrilled by his progress and future plans. Way to go Tushar !
buff.ly/epdJ298
buff.ly/epdJ298
Check it out! Dr. I Larina presented her technology to see and measure forces on a growing, beating #heart at #mbimpg2025.
@bcmhouston.bsky.social #BCMIntegrPhys @mbisg.bsky.social
@bcmhouston.bsky.social #BCMIntegrPhys @mbisg.bsky.social
September 12, 2025 at 2:13 PM
Check it out! Dr. I Larina presented her technology to see and measure forces on a growing, beating #heart at #mbimpg2025.
@bcmhouston.bsky.social #BCMIntegrPhys @mbisg.bsky.social
@bcmhouston.bsky.social #BCMIntegrPhys @mbisg.bsky.social
We would like to once again, thank all the sponsors for their generosity in supporting #MBIMPG2025 @leicamicrosystems.bsky.social @nikoninst.bsky.social @oxfordinstruments.bsky.social, Optics11Life, BGI, Office of Naval Research Global and Paeonia Foundation.
September 12, 2025 at 8:55 AM
We would like to once again, thank all the sponsors for their generosity in supporting #MBIMPG2025 @leicamicrosystems.bsky.social @nikoninst.bsky.social @oxfordinstruments.bsky.social, Optics11Life, BGI, Office of Naval Research Global and Paeonia Foundation.
That closes out #MBIMPG2025! It would not have been possible without the efforts of the Scientific Organizing Committee, and special thanks to the admin team, A/V support, and student volunteers for ensuring a smooth conference 👏
September 12, 2025 at 8:53 AM
That closes out #MBIMPG2025! It would not have been possible without the efforts of the Scientific Organizing Committee, and special thanks to the admin team, A/V support, and student volunteers for ensuring a smooth conference 👏
Congratulations to our three poster prize winners for #MBIMPG2025!
🏆Rituraj Marwaha; Das Lab
🏆Boon Heng Ng; Chan Lab
🏆Marie Cutiongco ; @wtzhaolab.bsky.social
Thanks to all of the 115(!) poster presenters – our judges had a hard time deciding!
🏆Rituraj Marwaha; Das Lab
🏆Boon Heng Ng; Chan Lab
🏆Marie Cutiongco ; @wtzhaolab.bsky.social
Thanks to all of the 115(!) poster presenters – our judges had a hard time deciding!
September 12, 2025 at 8:53 AM
Congratulations to our three poster prize winners for #MBIMPG2025!
🏆Rituraj Marwaha; Das Lab
🏆Boon Heng Ng; Chan Lab
🏆Marie Cutiongco ; @wtzhaolab.bsky.social
Thanks to all of the 115(!) poster presenters – our judges had a hard time deciding!
🏆Rituraj Marwaha; Das Lab
🏆Boon Heng Ng; Chan Lab
🏆Marie Cutiongco ; @wtzhaolab.bsky.social
Thanks to all of the 115(!) poster presenters – our judges had a hard time deciding!
Remarkable intravital two-photon imaging videos from @hirashima0203.bsky.social @mbisg.bsky.social visualising sperm movement through the epididymal duct, revealing how epithelial contractions promote active turbulence of sperm collectives, essential for sperm to acquire motility. #MBIMPG2025
September 12, 2025 at 8:25 AM
Remarkable intravital two-photon imaging videos from @hirashima0203.bsky.social @mbisg.bsky.social visualising sperm movement through the epididymal duct, revealing how epithelial contractions promote active turbulence of sperm collectives, essential for sperm to acquire motility. #MBIMPG2025
Zhao Wenting @wtzhaolab.bsky.social shared two complementary studies highlighting how immune cells use curvature-sensitive mechanisms to leverage on nanoscale membrane deformations- both intrinsic and extrinsic—regulating signaling and motility. #MBIMPG2025
September 12, 2025 at 8:02 AM
Zhao Wenting @wtzhaolab.bsky.social shared two complementary studies highlighting how immune cells use curvature-sensitive mechanisms to leverage on nanoscale membrane deformations- both intrinsic and extrinsic—regulating signaling and motility. #MBIMPG2025
Kim Whye Leong @mbisg.bsky.social examined lumen development in ovarian follicles, a key step for ovulation transitions from a fluid network into a phase-separated state, regulated by cell-fluid surface tension—these dynamics may help nutrient exchange. #MBIMPG2025
September 12, 2025 at 7:21 AM
Kim Whye Leong @mbisg.bsky.social examined lumen development in ovarian follicles, a key step for ovulation transitions from a fluid network into a phase-separated state, regulated by cell-fluid surface tension—these dynamics may help nutrient exchange. #MBIMPG2025
Daniel Stedman @jtimaging.bsky.social presented a method using widefield fluorescence lifetime imaging microscopy to measure molecular tension changes at cell-cell interfaces within the beating zebrafish heart—both across a heartbeat and across developmental time. #MBIMPG2025
September 12, 2025 at 7:02 AM
Daniel Stedman @jtimaging.bsky.social presented a method using widefield fluorescence lifetime imaging microscopy to measure molecular tension changes at cell-cell interfaces within the beating zebrafish heart—both across a heartbeat and across developmental time. #MBIMPG2025
Returning to multi-dimensional models, Amit Pathak @washuengineers.bsky.social detailed how cell mechanical memory is retained from stiff 2D to fibrous 3D collagen matrices—even in hypoxic environments—to better understand tumor invasion in evolving microenvironments. #MBIMPG2025
September 12, 2025 at 6:46 AM
Returning to multi-dimensional models, Amit Pathak @washuengineers.bsky.social detailed how cell mechanical memory is retained from stiff 2D to fibrous 3D collagen matrices—even in hypoxic environments—to better understand tumor invasion in evolving microenvironments. #MBIMPG2025
Mineko Kengaku from Kyoto University continues the theme by sharing how Piezo-1 switches on a force generation mechanism in neuron migration and how DNA damage due to mechanostress in these narrow interstitial spaces is repaired by enhanced expression of topolsomerase IIb. #MBIMPG2025
September 12, 2025 at 6:24 AM
Mineko Kengaku from Kyoto University continues the theme by sharing how Piezo-1 switches on a force generation mechanism in neuron migration and how DNA damage due to mechanostress in these narrow interstitial spaces is repaired by enhanced expression of topolsomerase IIb. #MBIMPG2025
Next, Tamal Das @tifr.res.in revealed the influence of lysosomes in leader cell formation and the ER in supporting lamellipodial crawling and purse-string contraction, identifying them as key integrators of mechanochemical cues to drive collective cell migration. #MBIMPG2025
September 12, 2025 at 4:29 AM
Next, Tamal Das @tifr.res.in revealed the influence of lysosomes in leader cell formation and the ER in supporting lamellipodial crawling and purse-string contraction, identifying them as key integrators of mechanochemical cues to drive collective cell migration. #MBIMPG2025
Decoding the programming of biological shapes, @carldmodes.bsky.social @math-mpicbg.bsky.social models epithelial cell sheets as an active solid—studying in-plane collective cell behaviour in Drosophila development, moving up in complexity from the 1D cephalic furrow to 3D wing disc. #MBIMPG2025
September 12, 2025 at 4:01 AM
Decoding the programming of biological shapes, @carldmodes.bsky.social @math-mpicbg.bsky.social models epithelial cell sheets as an active solid—studying in-plane collective cell behaviour in Drosophila development, moving up in complexity from the 1D cephalic furrow to 3D wing disc. #MBIMPG2025
After an energizing morning, look forward to our final session of #MBIMPG2025! Session 7 will cover the mechanics of developmental biology, from collective cell migration to differentiation, across time and space!
September 12, 2025 at 3:18 AM
After an energizing morning, look forward to our final session of #MBIMPG2025! Session 7 will cover the mechanics of developmental biology, from collective cell migration to differentiation, across time and space!
Just one more day of #MBIMPG2025 left! But plenty to look forward to—one last Session of scientific talks, and two social excursions to the jungles! An exotic morning rainforest jungle walk and evening drinks at the concrete jungle roof-top bars @ Marina Bay! 🏞️🍹 See you there!
September 11, 2025 at 10:21 AM
Just one more day of #MBIMPG2025 left! But plenty to look forward to—one last Session of scientific talks, and two social excursions to the jungles! An exotic morning rainforest jungle walk and evening drinks at the concrete jungle roof-top bars @ Marina Bay! 🏞️🍹 See you there!
Ivan Yow @mbisg.bsky.social @schmidtsciences.bsky.social investigated the mechanics of 3D spheroid formation. Fyn initiates spheroid formation via the RhoA-ROCK pathway, leading to increased tissue viscosity and tension - and may initiate cardiomyocyte transdifferentiation! #MBIMPG2025
September 11, 2025 at 10:12 AM
Ivan Yow @mbisg.bsky.social @schmidtsciences.bsky.social investigated the mechanics of 3D spheroid formation. Fyn initiates spheroid formation via the RhoA-ROCK pathway, leading to increased tissue viscosity and tension - and may initiate cardiomyocyte transdifferentiation! #MBIMPG2025
Back to compressive stress with Frank van Drogen. Combining a phospho-proteomic approach with RNAi-based validation, he looked at the ERK5 pathway in mammary gland cells, showing how it reduces tension promoting the migratory response to compression. #MBIMPG2025
September 11, 2025 at 10:01 AM
Back to compressive stress with Frank van Drogen. Combining a phospho-proteomic approach with RNAi-based validation, he looked at the ERK5 pathway in mammary gland cells, showing how it reduces tension promoting the migratory response to compression. #MBIMPG2025
Great talk from Elizabeth Chen @echenlab.bsky.social on how cell-cell fusion is a conserved, asymmetric process - where one cell invades the other through invasive, mechanically stiff actin protrusions (bundled by dynamin & WIP!), to form a fusogenic synapse. #MBIMPG2025
September 11, 2025 at 9:59 AM
Great talk from Elizabeth Chen @echenlab.bsky.social on how cell-cell fusion is a conserved, asymmetric process - where one cell invades the other through invasive, mechanically stiff actin protrusions (bundled by dynamin & WIP!), to form a fusogenic synapse. #MBIMPG2025
Michel Steinmetz @psich.bsky.social showed how microtubules structurally interact with GEFH1 through its C1 domain. Identification and validation of microtubule-binding C1 domains in other signalling proteins revealed how microtubules can both receive and mediate signal transduction. #MBIMPG2025
September 11, 2025 at 9:46 AM
Michel Steinmetz @psich.bsky.social showed how microtubules structurally interact with GEFH1 through its C1 domain. Identification and validation of microtubule-binding C1 domains in other signalling proteins revealed how microtubules can both receive and mediate signal transduction. #MBIMPG2025
Time for some plant mechanobiology Yansong Miao from NTU Singapore spoke about how condensation drives immunity in plant cells. Using phase separation, modelling and biophysics, he presented how the mechanical scaffolding structure of the plant cell changes to combat pathogens. #MBIMPG2025
September 11, 2025 at 9:40 AM
Time for some plant mechanobiology Yansong Miao from NTU Singapore spoke about how condensation drives immunity in plant cells. Using phase separation, modelling and biophysics, he presented how the mechanical scaffolding structure of the plant cell changes to combat pathogens. #MBIMPG2025
@artemefremov.bsky.social tested a semi-analytical model that integrates experimental data and theory, revealing the importance of adaptor protein elasticity and local molecular clutch-ECM interactions in cell mechanosensing and force transduction during adhesion. #MBIMPG2025
September 11, 2025 at 9:37 AM
@artemefremov.bsky.social tested a semi-analytical model that integrates experimental data and theory, revealing the importance of adaptor protein elasticity and local molecular clutch-ECM interactions in cell mechanosensing and force transduction during adhesion. #MBIMPG2025
Liubov Izmaylova focused on transepithelial invasion, a vital step for successful embryo implantation. By developing a novel 3D model to visualize invasion, she identified the importance of heterologous desmosomes between trophoblast and epithelia. #MBIMPG2025
September 11, 2025 at 7:35 AM
Liubov Izmaylova focused on transepithelial invasion, a vital step for successful embryo implantation. By developing a novel 3D model to visualize invasion, she identified the importance of heterologous desmosomes between trophoblast and epithelia. #MBIMPG2025
More on compression! Michael Samuel detailed how compressive stress from rapid mammary tumour growth triggers a Piezo1-dependent pathway that activates Rho-ROCK-mediated mechanosignaling contributing to a mechanical memory that drives cancer progression. #MBIMPG2025
September 11, 2025 at 7:33 AM
More on compression! Michael Samuel detailed how compressive stress from rapid mammary tumour growth triggers a Piezo1-dependent pathway that activates Rho-ROCK-mediated mechanosignaling contributing to a mechanical memory that drives cancer progression. #MBIMPG2025
Eugenia Piddini shares recent work on how differential p53 activity triggers mechanically driven cell competition: p53KO hESCs resist high‑density compaction and exhibit increased mechanical fitness. This allows them to eliminate WT cells and drives clonal dominance. #MBIMPG2025
September 11, 2025 at 7:22 AM
Eugenia Piddini shares recent work on how differential p53 activity triggers mechanically driven cell competition: p53KO hESCs resist high‑density compaction and exhibit increased mechanical fitness. This allows them to eliminate WT cells and drives clonal dominance. #MBIMPG2025