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Reposted by Mechanobiology Institute

Physics of Life Dresden @poldresden.bsky.social · 16h

Attention colleagues! Interested in an interdisciplinary #PhD? 🧬 Apply now for one of 12 PhD positions exploring biomolecular #condensates! This program involves several PoL PIs, bridging the gap between physics and biology.

Apply here: dresdencondensates.org/join-us/
🗓Deadline: 24. October

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Reposted by Mechanobiology Institute

GdR ImaBio @gdrimabio.bsky.social · 4d

#Mifobio2025
Focus on the module 4 :
👉 Multi-scale imaging of biological systems

We are delighted to welcome Anne BEGHIN @mbisg.bsky.social

Lecture - “Breaking scale: Image Analysis–Based AI to Streamline multilevels 3D quantitative Imaging and Tackle the vEM Challenge”

#GDRimabio

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Reposted by Mechanobiology Institute

Benoit Ladoux @bladoux.bsky.social · 21d

We’re organizing a conference at @ijmonod.bsky.social in Paris, January 2026, in memory of M.P. Sheetz — pioneer in cell mechanics and mechanobiology, co-discoverer of kinesin, and founder of @mbisg.bsky.social. Join us to explore his legacy.

mikeinmemoriam.sciencesconf.org

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Reposted by Mechanobiology Institute

Mariana Romeiro Motta @marianattom.bsky.social · 24d

Have you ever wondered how microtubules withstand and respond to mechanical stress in cells?

Here we show by in vitro reconstitution assays that MAP65-1 and PRC1 promote microtubule nucleation on existing lattices, especially on those with structural irregularities linked to mechanical stress.

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Mechanobiology Institute @mbisg.bsky.social · 27d

We would like to once again, thank all the sponsors for their generosity in supporting #MBIMPG2025 @leicamicrosystems.bsky.social @nikoninst.bsky.social @oxfordinstruments.bsky.social, Optics11Life, BGI, Office of Naval Research Global and Paeonia Foundation.

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Mechanobiology Institute @mbisg.bsky.social · 27d

That closes out #MBIMPG2025! It would not have been possible without the efforts of the Scientific Organizing Committee, and special thanks to the admin team, A/V support, and student volunteers for ensuring a smooth conference 👏

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Mechanobiology Institute @mbisg.bsky.social · 27d

Congratulations to our three poster prize winners for #MBIMPG2025!
🏆Rituraj Marwaha; Das Lab
🏆Boon Heng Ng; Chan Lab
🏆Marie Cutiongco ; @wtzhaolab.bsky.social
Thanks to all of the 115(!) poster presenters – our judges had a hard time deciding!

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Mechanobiology Institute @mbisg.bsky.social · 27d

Remarkable intravital two-photon imaging videos from @hirashima0203.bsky.social @mbisg.bsky.social visualising sperm movement through the epididymal duct, revealing how epithelial contractions promote active turbulence of sperm collectives, essential for sperm to acquire motility. #MBIMPG2025

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Mechanobiology Institute @mbisg.bsky.social · 27d

Zhao Wenting @wtzhaolab.bsky.social shared two complementary studies highlighting how immune cells use curvature-sensitive mechanisms to leverage on nanoscale membrane deformations- both intrinsic and extrinsic—regulating signaling and motility. #MBIMPG2025

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Mechanobiology Institute @mbisg.bsky.social · 27d

Kim Whye Leong @mbisg.bsky.social examined lumen development in ovarian follicles, a key step for ovulation transitions from a fluid network into a phase-separated state, regulated by cell-fluid surface tension—these dynamics may help nutrient exchange. #MBIMPG2025

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Mechanobiology Institute @mbisg.bsky.social · 27d

Daniel Stedman @jtimaging.bsky.social presented a method using widefield fluorescence lifetime imaging microscopy to measure molecular tension changes at cell-cell interfaces within the beating zebrafish heart—both across a heartbeat and across developmental time. #MBIMPG2025

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Mechanobiology Institute @mbisg.bsky.social · 28d

Returning to multi-dimensional models, Amit Pathak @washuengineers.bsky.social detailed how cell mechanical memory is retained from stiff 2D to fibrous 3D collagen matrices—even in hypoxic environments—to better understand tumor invasion in evolving microenvironments. #MBIMPG2025

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Mechanobiology Institute @mbisg.bsky.social · 28d

Mineko Kengaku from Kyoto University continues the theme by sharing how Piezo-1 switches on a force generation mechanism in neuron migration and how DNA damage due to mechanostress in these narrow interstitial spaces is repaired by enhanced expression of topolsomerase IIb. #MBIMPG2025

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Mechanobiology Institute @mbisg.bsky.social · 28d

Next, Tamal Das @tifr.res.in revealed the influence of lysosomes in leader cell formation and the ER in supporting lamellipodial crawling and purse-string contraction, identifying them as key integrators of mechanochemical cues to drive collective cell migration. #MBIMPG2025

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Mechanobiology Institute @mbisg.bsky.social · 28d

Decoding the programming of biological shapes, @carldmodes.bsky.social @math-mpicbg.bsky.social models epithelial cell sheets as an active solid—studying in-plane collective cell behaviour in Drosophila development, moving up in complexity from the 1D cephalic furrow to 3D wing disc. #MBIMPG2025

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Mechanobiology Institute @mbisg.bsky.social · 28d

After an energizing morning, look forward to our final session of #MBIMPG2025! Session 7 will cover the mechanics of developmental biology, from collective cell migration to differentiation, across time and space!

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Mechanobiology Institute @mbisg.bsky.social · 28d

Just one more day of #MBIMPG2025 left! But plenty to look forward to—one last Session of scientific talks, and two social excursions to the jungles! An exotic morning rainforest jungle walk and evening drinks at the concrete jungle roof-top bars @ Marina Bay! 🏞️🍹 See you there!

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Mechanobiology Institute @mbisg.bsky.social · 28d

Ivan Yow @mbisg.bsky.social @schmidtsciences.bsky.social investigated the mechanics of 3D spheroid formation. Fyn initiates spheroid formation via the RhoA-ROCK pathway, leading to increased tissue viscosity and tension - and may initiate cardiomyocyte transdifferentiation! #MBIMPG2025

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Mechanobiology Institute @mbisg.bsky.social · 28d

Back to compressive stress with Frank van Drogen. Combining a phospho-proteomic approach with RNAi-based validation, he looked at the ERK5 pathway in mammary gland cells, showing how it reduces tension promoting the migratory response to compression. #MBIMPG2025

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Mechanobiology Institute @mbisg.bsky.social · 28d

Great talk from Elizabeth Chen @echenlab.bsky.social on how cell-cell fusion is a conserved, asymmetric process - where one cell invades the other through invasive, mechanically stiff actin protrusions (bundled by dynamin & WIP!), to form a fusogenic synapse. #MBIMPG2025

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Mechanobiology Institute @mbisg.bsky.social · 28d

Michel Steinmetz @psich.bsky.social showed how microtubules structurally interact with GEFH1 through its C1 domain. Identification and validation of microtubule-binding C1 domains in other signalling proteins revealed how microtubules can both receive and mediate signal transduction. #MBIMPG2025

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Mechanobiology Institute @mbisg.bsky.social · 28d

Time for some plant mechanobiology Yansong Miao from NTU Singapore spoke about how condensation drives immunity in plant cells. Using phase separation, modelling and biophysics, he presented how the mechanical scaffolding structure of the plant cell changes to combat pathogens. #MBIMPG2025

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Mechanobiology Institute @mbisg.bsky.social · 28d

@artemefremov.bsky.social tested a semi-analytical model that integrates experimental data and theory, revealing the importance of adaptor protein elasticity and local molecular clutch-ECM interactions in cell mechanosensing and force transduction during adhesion. #MBIMPG2025

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Mechanobiology Institute @mbisg.bsky.social · 28d

Liubov Izmaylova focused on transepithelial invasion, a vital step for successful embryo implantation. By developing a novel 3D model to visualize invasion, she identified the importance of heterologous desmosomes between trophoblast and epithelia. #MBIMPG2025

Mechanobiology Institute @mbisg.bsky.social · 28d

More on compression! Michael Samuel detailed how compressive stress from rapid mammary tumour growth triggers a Piezo1-dependent pathway that activates Rho-ROCK-mediated mechanosignaling contributing to a mechanical memory that drives cancer progression. #MBIMPG2025