Is Tyvaso dpi 64mcg working for me? Yessss! This is the highest my resting sat has ever been over the course of 16 years! 🥳🙌🏼
#pulmonaryarterialhypertension
#pulmonaryarterialhypertension
January 26, 2026 at 9:59 PM
Is Tyvaso dpi 64mcg working for me? Yessss! This is the highest my resting sat has ever been over the course of 16 years! 🥳🙌🏼
#pulmonaryarterialhypertension
#pulmonaryarterialhypertension
A new study by researchers in the US identified histone acetyltransferase #EP300 as a central epigenetic regulator of endothelial dysfunction in patients with pulmonary arterial hypertension (#PAH).
Read more: https://bit.ly/4bBsCLn
#RareDisease #Pulmonology #PulmonaryArterialHypertension
Read more: https://bit.ly/4bBsCLn
#RareDisease #Pulmonology #PulmonaryArterialHypertension
Targeting Histone Acetylation May Be a Promising Therapeutic Avenue in PAH
Research shows that histone acetyltransferase EP300 plays a central role in the epigenetic regulation of endothelial dysfunction in patients with PAH.
bit.ly
January 19, 2026 at 8:51 PM
A new study by researchers in the US identified histone acetyltransferase #EP300 as a central epigenetic regulator of endothelial dysfunction in patients with pulmonary arterial hypertension (#PAH).
Read more: https://bit.ly/4bBsCLn
#RareDisease #Pulmonology #PulmonaryArterialHypertension
Read more: https://bit.ly/4bBsCLn
#RareDisease #Pulmonology #PulmonaryArterialHypertension
A question on #PulmonaryArterialHypertension tabled by Daisy Cooper on 09-12-2025 has been answered by Karin Smyth. https://questions-statements.parliament.uk/written-questions/detail/2025-12-09/98511
December 16, 2025 at 7:11 PM
A question on #PulmonaryArterialHypertension tabled by Daisy Cooper on 09-12-2025 has been answered by Karin Smyth. https://questions-statements.parliament.uk/written-questions/detail/2025-12-09/98511
Resistance exercise training attenuates skeletal muscle atrophy in experimental pulmonary arterial hypertension.
Costa, Sebastião Felipe Ferreira et al.
Paper
Details
#ResistanceTraining #PulmonaryArterialHypertension #MuscleAtrophyRecovery
Costa, Sebastião Felipe Ferreira et al.
Paper
Details
#ResistanceTraining #PulmonaryArterialHypertension #MuscleAtrophyRecovery
December 10, 2025 at 9:01 AM
Resistance exercise training attenuates skeletal muscle atrophy in experimental pulmonary arterial hypertension.
Costa, Sebastião Felipe Ferreira et al.
Paper
Details
#ResistanceTraining #PulmonaryArterialHypertension #MuscleAtrophyRecovery
Costa, Sebastião Felipe Ferreira et al.
Paper
Details
#ResistanceTraining #PulmonaryArterialHypertension #MuscleAtrophyRecovery
#RNAEditing #PulmonaryArterialHypertension
ADAR1 (both p150 & p110 isoforms) ⬇️in 👤PAH (in 🫁vascular smooth muscle cell)
SMC ADAR1 KO🐭 excerbates PAH
SMC ⏫dsRNA➡️⏫PKR-eIF2B-IFNβ➡️
Macrophage M1 polarization➡️
SMC proliferation
@kekeyuan.bsky.social #CircRes 2025
www.ahajournals.org/doi/10.1161/...
ADAR1 (both p150 & p110 isoforms) ⬇️in 👤PAH (in 🫁vascular smooth muscle cell)
SMC ADAR1 KO🐭 excerbates PAH
SMC ⏫dsRNA➡️⏫PKR-eIF2B-IFNβ➡️
Macrophage M1 polarization➡️
SMC proliferation
@kekeyuan.bsky.social #CircRes 2025
www.ahajournals.org/doi/10.1161/...
November 23, 2025 at 12:37 PM
#RNAEditing #PulmonaryArterialHypertension
ADAR1 (both p150 & p110 isoforms) ⬇️in 👤PAH (in 🫁vascular smooth muscle cell)
SMC ADAR1 KO🐭 excerbates PAH
SMC ⏫dsRNA➡️⏫PKR-eIF2B-IFNβ➡️
Macrophage M1 polarization➡️
SMC proliferation
@kekeyuan.bsky.social #CircRes 2025
www.ahajournals.org/doi/10.1161/...
ADAR1 (both p150 & p110 isoforms) ⬇️in 👤PAH (in 🫁vascular smooth muscle cell)
SMC ADAR1 KO🐭 excerbates PAH
SMC ⏫dsRNA➡️⏫PKR-eIF2B-IFNβ➡️
Macrophage M1 polarization➡️
SMC proliferation
@kekeyuan.bsky.social #CircRes 2025
www.ahajournals.org/doi/10.1161/...
#PFFSummit: Karen Smoot of Albuquerque, New Mexico, PFF patient ambassador who lives with both #IdiopathicPulmonaryFibrosis and #PulmonaryArterialHypertension. Smoot, 79, spoke Nov. 14 at the 2025 PFF Summit in Chicago
Image & quote taken by Senior Correspondent, Larry Luxner.
#RareDisease #MedSky
Image & quote taken by Senior Correspondent, Larry Luxner.
#RareDisease #MedSky
November 15, 2025 at 3:00 PM
#PFFSummit: Karen Smoot of Albuquerque, New Mexico, PFF patient ambassador who lives with both #IdiopathicPulmonaryFibrosis and #PulmonaryArterialHypertension. Smoot, 79, spoke Nov. 14 at the 2025 PFF Summit in Chicago
Image & quote taken by Senior Correspondent, Larry Luxner.
#RareDisease #MedSky
Image & quote taken by Senior Correspondent, Larry Luxner.
#RareDisease #MedSky
Adding the #BiologicDrug #sotatercept to standard therapy within the first year after diagnosis significantly lowers the risk of disease worsening in patients with the most severe form of #PulmonaryHypertension.
#PulmonaryArterialHypertension
#PulmonaryArterialHypertension
Biologic drug reduces symptoms and hospitalizations in severe pulmonary hypertension – BioNews Central
Adding the biologic drug sotatercept to standard therapy within the first year after diagnosis significantly lowers the risk of disease worsening in patients with the most severe form of pulmonary hypertension. ...
sbee.link
October 1, 2025 at 12:56 PM
Adding the #BiologicDrug #sotatercept to standard therapy within the first year after diagnosis significantly lowers the risk of disease worsening in patients with the most severe form of #PulmonaryHypertension.
#PulmonaryArterialHypertension
#PulmonaryArterialHypertension
Advance your understanding of the growing connection between #pulmonaryarterialhypertension and substance use at #PHPN2025, Sept. 18-20, in Seattle.
Attend the 2025 #PHPN Symposium to learn the latest in #PH treatment, research and care. Register now to secure your spot. buff.ly/ol6lvWU
Attend the 2025 #PHPN Symposium to learn the latest in #PH treatment, research and care. Register now to secure your spot. buff.ly/ol6lvWU
August 1, 2025 at 4:00 PM
Advance your understanding of the growing connection between #pulmonaryarterialhypertension and substance use at #PHPN2025, Sept. 18-20, in Seattle.
Attend the 2025 #PHPN Symposium to learn the latest in #PH treatment, research and care. Register now to secure your spot. buff.ly/ol6lvWU
Attend the 2025 #PHPN Symposium to learn the latest in #PH treatment, research and care. Register now to secure your spot. buff.ly/ol6lvWU
#NT-proBNP and #BNP Testing in #PulmonaryArterialHypertension: Point-of-Care and Remote Monitoring
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
July 16, 2025 at 1:01 AM
#NT-proBNP and #BNP Testing in #PulmonaryArterialHypertension: Point-of-Care and Remote Monitoring
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
#EndothelialCell Metabolism #PulmonaryArterialHypertension
FABP4/5 KO⏬PAH & normalizes EC population shift (⏫Arterial EC ⏬Aerocyte Ven EC) in Tie2+ PHD2 KO🐭
Lenti-FABP4/5 ⏫Glycolysis & FAO in hPAEC
@zhiyudai.bsky.social #ATVB 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/full/10....
FABP4/5 KO⏬PAH & normalizes EC population shift (⏫Arterial EC ⏬Aerocyte Ven EC) in Tie2+ PHD2 KO🐭
Lenti-FABP4/5 ⏫Glycolysis & FAO in hPAEC
@zhiyudai.bsky.social #ATVB 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/full/10....
July 13, 2025 at 12:06 PM
#EndothelialCell Metabolism #PulmonaryArterialHypertension
FABP4/5 KO⏬PAH & normalizes EC population shift (⏫Arterial EC ⏬Aerocyte Ven EC) in Tie2+ PHD2 KO🐭
Lenti-FABP4/5 ⏫Glycolysis & FAO in hPAEC
@zhiyudai.bsky.social #ATVB 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/full/10....
FABP4/5 KO⏬PAH & normalizes EC population shift (⏫Arterial EC ⏬Aerocyte Ven EC) in Tie2+ PHD2 KO🐭
Lenti-FABP4/5 ⏫Glycolysis & FAO in hPAEC
@zhiyudai.bsky.social #ATVB 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/full/10....
#TuberousSclerosisComplex #PulmonaryArterialHypertension
#MatrixStiffness 25 kPa-induced loss of TSC2 in PA #SmoothMuscleCell➡️
⏫mTOR & #YAP/TAZ➡️
⏫PASMC proliferation & ECM deposit (➡️fibroblast proliferation)
SM22a+ SMC het KO🐭of Tsc2➡️PAH at 9-wk
#SciSignal 2022
www.science.org/doi/10.1126/...
#MatrixStiffness 25 kPa-induced loss of TSC2 in PA #SmoothMuscleCell➡️
⏫mTOR & #YAP/TAZ➡️
⏫PASMC proliferation & ECM deposit (➡️fibroblast proliferation)
SM22a+ SMC het KO🐭of Tsc2➡️PAH at 9-wk
#SciSignal 2022
www.science.org/doi/10.1126/...
July 11, 2025 at 12:05 PM
#TuberousSclerosisComplex #PulmonaryArterialHypertension
#MatrixStiffness 25 kPa-induced loss of TSC2 in PA #SmoothMuscleCell➡️
⏫mTOR & #YAP/TAZ➡️
⏫PASMC proliferation & ECM deposit (➡️fibroblast proliferation)
SM22a+ SMC het KO🐭of Tsc2➡️PAH at 9-wk
#SciSignal 2022
www.science.org/doi/10.1126/...
#MatrixStiffness 25 kPa-induced loss of TSC2 in PA #SmoothMuscleCell➡️
⏫mTOR & #YAP/TAZ➡️
⏫PASMC proliferation & ECM deposit (➡️fibroblast proliferation)
SM22a+ SMC het KO🐭of Tsc2➡️PAH at 9-wk
#SciSignal 2022
www.science.org/doi/10.1126/...
PAH-former: Transfer Learning for Efficient Discovery of Pulmonary Arterial Hypertension-Associated Genes
Hosokawa, S., Isagawa, T. et al.
Paper
Details
#PulmonaryArterialHypertension #GeneticResearch #TransferLearningAI
Hosokawa, S., Isagawa, T. et al.
Paper
Details
#PulmonaryArterialHypertension #GeneticResearch #TransferLearningAI
June 21, 2025 at 9:01 AM
PAH-former: Transfer Learning for Efficient Discovery of Pulmonary Arterial Hypertension-Associated Genes
Hosokawa, S., Isagawa, T. et al.
Paper
Details
#PulmonaryArterialHypertension #GeneticResearch #TransferLearningAI
Hosokawa, S., Isagawa, T. et al.
Paper
Details
#PulmonaryArterialHypertension #GeneticResearch #TransferLearningAI
So, yes, I do feel insecure about reducing and hopefully stopping Remodulin via pump, but to know that I am guarded by the doctors and nurses at @hopitalbicetre.bsky.social also reassures me. I wouldn’t try without them. That’s the benefit of trust, I guess. ☺️ #PAH #PulmonaryArterialHypertension
June 3, 2025 at 10:33 AM
So, yes, I do feel insecure about reducing and hopefully stopping Remodulin via pump, but to know that I am guarded by the doctors and nurses at @hopitalbicetre.bsky.social also reassures me. I wouldn’t try without them. That’s the benefit of trust, I guess. ☺️ #PAH #PulmonaryArterialHypertension
So, apparently #Sotatercept works fine in my body. Beginning next week we are reducing #Remodulin and if I am VERY, VERY lucky I may live without a pump from the beginning of August on. It’s a strange feeling, a mixture of hope, excitement and insecurity for sure! #PAH #PulmonaryArterialHypertension
June 3, 2025 at 10:30 AM
So, apparently #Sotatercept works fine in my body. Beginning next week we are reducing #Remodulin and if I am VERY, VERY lucky I may live without a pump from the beginning of August on. It’s a strange feeling, a mixture of hope, excitement and insecurity for sure! #PAH #PulmonaryArterialHypertension
Panorama
Patient Perspectives and Clinical Insights Into the Diagnostic Journey From Connective Tissue Disease to Pulmonary Arterial Hypertension
📖 doi.org/10.3899/jrhe...
#connectivetissuedisorders #pulmonaryarterialhypertension
Patient Perspectives and Clinical Insights Into the Diagnostic Journey From Connective Tissue Disease to Pulmonary Arterial Hypertension
📖 doi.org/10.3899/jrhe...
#connectivetissuedisorders #pulmonaryarterialhypertension
May 20, 2025 at 4:17 PM
Panorama
Patient Perspectives and Clinical Insights Into the Diagnostic Journey From Connective Tissue Disease to Pulmonary Arterial Hypertension
📖 doi.org/10.3899/jrhe...
#connectivetissuedisorders #pulmonaryarterialhypertension
Patient Perspectives and Clinical Insights Into the Diagnostic Journey From Connective Tissue Disease to Pulmonary Arterial Hypertension
📖 doi.org/10.3899/jrhe...
#connectivetissuedisorders #pulmonaryarterialhypertension
@imperialcollegeldn.bsky.social is working with biopharmaceutical company Apollo Therapeutics to develop a prospective monoclonal antibody treatment for pulmonary arterial hypertension.
healthcaretoday.com/article/a-ne...
#healthcare #biopharmaceutical #antibody #pulmonaryarterialhypertension
healthcaretoday.com/article/a-ne...
#healthcare #biopharmaceutical #antibody #pulmonaryarterialhypertension
A new treatment for pulmonary arterial hypertension
Imperial College London and Apollo Therapeutics have developed a new treatment based on a protein target identified in 2015.
healthcaretoday.com
May 20, 2025 at 8:57 AM
@imperialcollegeldn.bsky.social is working with biopharmaceutical company Apollo Therapeutics to develop a prospective monoclonal antibody treatment for pulmonary arterial hypertension.
healthcaretoday.com/article/a-ne...
#healthcare #biopharmaceutical #antibody #pulmonaryarterialhypertension
healthcaretoday.com/article/a-ne...
#healthcare #biopharmaceutical #antibody #pulmonaryarterialhypertension
A new🐭model of #PulmonaryArterialHypertension
Left pneumonectomy▶️⏫🫁flow +Hypoxia
👉Fulton index ~40%🥵
👉ACTA2+ #SmoothMuscleCell, Not EC/pericyte, as the major cellular source of distal arteriole muscularization
👉 A role of SMC CXCL12😁
@kekeyuan.bsky.social #JBC 2025
www.jbc.org/article/S002...
Left pneumonectomy▶️⏫🫁flow +Hypoxia
👉Fulton index ~40%🥵
👉ACTA2+ #SmoothMuscleCell, Not EC/pericyte, as the major cellular source of distal arteriole muscularization
👉 A role of SMC CXCL12😁
@kekeyuan.bsky.social #JBC 2025
www.jbc.org/article/S002...
May 12, 2025 at 7:08 PM
A new🐭model of #PulmonaryArterialHypertension
Left pneumonectomy▶️⏫🫁flow +Hypoxia
👉Fulton index ~40%🥵
👉ACTA2+ #SmoothMuscleCell, Not EC/pericyte, as the major cellular source of distal arteriole muscularization
👉 A role of SMC CXCL12😁
@kekeyuan.bsky.social #JBC 2025
www.jbc.org/article/S002...
Left pneumonectomy▶️⏫🫁flow +Hypoxia
👉Fulton index ~40%🥵
👉ACTA2+ #SmoothMuscleCell, Not EC/pericyte, as the major cellular source of distal arteriole muscularization
👉 A role of SMC CXCL12😁
@kekeyuan.bsky.social #JBC 2025
www.jbc.org/article/S002...
Could a new treatment for #PulmonaryArterialHypertension be on the horizon?
@imperialcollegeldn.bsky.social and Apollo Therapeutics are developing an antibody treatment which could alleviate patients’ symptoms and extend their lives.
@imperialnhli.bsky.social www.imperial.ac.uk/news/263593/...
@imperialcollegeldn.bsky.social and Apollo Therapeutics are developing an antibody treatment which could alleviate patients’ symptoms and extend their lives.
@imperialnhli.bsky.social www.imperial.ac.uk/news/263593/...
Imperial and Apollo developing potential treatment for pulmonary hypertension | Imperial News | Imperial College London
A partnership designed to rapidly turn scientific breakthroughs into medicines has yielded a potential treatment for pulmonary arterial hypertension.
www.imperial.ac.uk
May 6, 2025 at 1:43 PM
Could a new treatment for #PulmonaryArterialHypertension be on the horizon?
@imperialcollegeldn.bsky.social and Apollo Therapeutics are developing an antibody treatment which could alleviate patients’ symptoms and extend their lives.
@imperialnhli.bsky.social www.imperial.ac.uk/news/263593/...
@imperialcollegeldn.bsky.social and Apollo Therapeutics are developing an antibody treatment which could alleviate patients’ symptoms and extend their lives.
@imperialnhli.bsky.social www.imperial.ac.uk/news/263593/...
May is Lupus Awareness Month. It’s estimated that about 2% of people with lupus will develop #pulmonaryarterialhypertension, but screening for patients is not routine.
Learn more about the connection between lupus and PAH in our free brochure. buff.ly/qBDrFlw
#MakeLupusVisible
Learn more about the connection between lupus and PAH in our free brochure. buff.ly/qBDrFlw
#MakeLupusVisible
May 2, 2025 at 2:31 PM
May is Lupus Awareness Month. It’s estimated that about 2% of people with lupus will develop #pulmonaryarterialhypertension, but screening for patients is not routine.
Learn more about the connection between lupus and PAH in our free brochure. buff.ly/qBDrFlw
#MakeLupusVisible
Learn more about the connection between lupus and PAH in our free brochure. buff.ly/qBDrFlw
#MakeLupusVisible
Right heart cath day is tmrw.
Am I nervous even tho I’ve had 8 of these over the last 15 years?
Yes.
Am I a mfkn badass?
Always. #pulmonaryarterialhypertension
Am I nervous even tho I’ve had 8 of these over the last 15 years?
Yes.
Am I a mfkn badass?
Always. #pulmonaryarterialhypertension
a little girl is riding a toy jeep with a doll in the back seat
ALT: a little girl is riding a toy jeep with a doll in the back seat
media.tenor.com
April 27, 2025 at 4:59 PM
Right heart cath day is tmrw.
Am I nervous even tho I’ve had 8 of these over the last 15 years?
Yes.
Am I a mfkn badass?
Always. #pulmonaryarterialhypertension
Am I nervous even tho I’ve had 8 of these over the last 15 years?
Yes.
Am I a mfkn badass?
Always. #pulmonaryarterialhypertension
Editorial
Unveiling the Dual Benefits of Bosentan in Systemic Sclerosis: Risk and Relief
📖 doi.org/10.3899/jrhe...
@hopkinsmedicine.bsky.social @mmukherjeemd.bsky.social
#Bosentan #digitalulcers #pulmonaryarterialhypertension #systemicsclerosis
Unveiling the Dual Benefits of Bosentan in Systemic Sclerosis: Risk and Relief
📖 doi.org/10.3899/jrhe...
@hopkinsmedicine.bsky.social @mmukherjeemd.bsky.social
#Bosentan #digitalulcers #pulmonaryarterialhypertension #systemicsclerosis
April 4, 2025 at 3:43 PM
Editorial
Unveiling the Dual Benefits of Bosentan in Systemic Sclerosis: Risk and Relief
📖 doi.org/10.3899/jrhe...
@hopkinsmedicine.bsky.social @mmukherjeemd.bsky.social
#Bosentan #digitalulcers #pulmonaryarterialhypertension #systemicsclerosis
Unveiling the Dual Benefits of Bosentan in Systemic Sclerosis: Risk and Relief
📖 doi.org/10.3899/jrhe...
@hopkinsmedicine.bsky.social @mmukherjeemd.bsky.social
#Bosentan #digitalulcers #pulmonaryarterialhypertension #systemicsclerosis
#Dasatinib-Induced #PulmonaryArterialHypertension in Chronic Myeloid #Leukaemia: A Case Report and Literature Review
onlinelibrary.wiley.com
April 4, 2025 at 3:00 AM
#Dasatinib-Induced #PulmonaryArterialHypertension in Chronic Myeloid #Leukaemia: A Case Report and Literature Review
Is anyone in the #pulmonaryarterialhypertension community worried about losing access to lifesaving treatments? I'm on Winrevair & titrating off Veletri. I'm worried that we will get cut off. Cut off of copay assistance, and lose our medicare/caid/social security.
1/2
1/2
February 23, 2025 at 11:34 PM
Is anyone in the #pulmonaryarterialhypertension community worried about losing access to lifesaving treatments? I'm on Winrevair & titrating off Veletri. I'm worried that we will get cut off. Cut off of copay assistance, and lose our medicare/caid/social security.
1/2
1/2
Very privileged to be part of this new paper on future treatment paradigms in #PulmonaryArterialHypertension in the @lancetrespirmed.bsky.social
@sandeepsahaymd.bsky.social
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
@sandeepsahaymd.bsky.social
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
kwnsfk27.r.eu-west-1.awstrack.me
February 21, 2025 at 2:29 AM
Very privileged to be part of this new paper on future treatment paradigms in #PulmonaryArterialHypertension in the @lancetrespirmed.bsky.social
@sandeepsahaymd.bsky.social
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
@sandeepsahaymd.bsky.social
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
About 13% of #pulmonaryarterialhypertension patients report having heart palpitations as a symptom. Learn about #PAH, Group 1 #PH, for #AmericanHeartMonth. https://buff.ly/4gt1ZqM . #OurHearts
February 19, 2025 at 3:22 PM
About 13% of #pulmonaryarterialhypertension patients report having heart palpitations as a symptom. Learn about #PAH, Group 1 #PH, for #AmericanHeartMonth. https://buff.ly/4gt1ZqM . #OurHearts